Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Female first cousins, aged 21 and 2 1/2 years, with many of the characteristic features of trisomy 18, were found to have identical unbalanced translocations, 46,XX,--13, + der(13)t(13;18) (p13;q12)mat. Clinical features of another cousin, two uncles, and an aunt suggested that they, too, had a partial trisomy 18 phenotype. The long survival and normal menstrual and secondary sexual development in one case are remarkable. A heritable balanced translocation, 46,XX or XY, t(13;18) (p13;q12), was detected in the mothers of the cases, a sib, an aunt, and two uncles. Translocation carriers had abnormalities in gonadal structure or function, with aspermia in males and polycystic ovaries with infertility in several females, suggesting that some gene controlling reproductive development occurs on the long arm of chromosome 18, with normal function interrupted at the breakpoint. Balanced translocation carriers may also be at greater risk for both benign and malignant neoplasms, which included acute leukaemia in an uncle and adenocarcinoma of the stomach at an early age in the grandmother. Although aetiological laboratory studies identified no premalignant state, the clinical findings suggest a defect that may predispose to cytogenetic abnormalities and malignancy.
 ...
PMID:Clinical manifestations of familial 13;18 translocation. 721 77

Antifertility effects of dimethylmyleran on the male Sprague-Dawley rat were investigated. Isomers were administered ip. Each isomer acted in a specific manner. The isomers were more active in this strain of rats than in the Wistar strain previously studied. The meso-isomer caused sterility from Week 7 whereas other mixtures had a similar action from Weeks 8 to 10. The antifertility action was due to the production of aspermia or oligospermia. Dimethylmyleran has been used in the treatment of garanulocytic leukemia, with a potency 3 times that of myleran (Busulphan). Clinical studies and experiments have been based on the use of a mixture of the isomeric forms of the drug. The meso-isomer has caused a high incidence of fetal malformations in Sprague-Dawley rats.
 ...
PMID:Effect of the anti-leukaemic drug dimethylmyleran on the reproductive system of the rat. 1227 82