Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Complications of the central nervous system are not uncommon in patients with a diagnosis of leukemia including infections and hemorrhage. We present the magnetic resonance (MR) findings of granulocytic sarcoma (chloroma) in two leukemic patients who presented with masses in the cerebellopontine angle and in the cavernous and the sphenoid sinuses. The MR signal displayed by these two lesions was isointense to the brain on both T1- and T2-weighted images. This signal intensity differs from that observed in cases of hemorrhage or infection.
 ...
PMID:Intracranial granulocytic sarcoma (chloroma): MR findings. 350 Jan 92

A patient with an abdominal mass for 4 years developed hypereosinophilia and weight loss. Bone marrow aspirations and biopsy specimens showed hypercellularity of eosinophils. No cause for hypereosinophilia was found. Biopsy specimens of several organs, including the abdominal mass, showed eosinophilic infiltration with reactive fibrosis in some. Cytogenetic studies of the bone marrow before treatment with cytoxic drugs showed chromosomal abnormalities. Several of these have been reported in association with acute or eosinophilic leukemias. Based upon these findings, the authors believe that the patient had eosinophilic leukemia and that the abdominal mass probably was an eosinophilic chloroma.
 ...
PMID:Is hypereosinophilic syndrome a malignant disease? 385 5

A patient presented with unilateral obstructive nephropathy due to a granulocytic sarcoma (chloroma) arising within the renal pelvis. To the best of our knowledge, granulocytic sarcoma has not previously been described either arising in the urinary system or occurring during induced remission of disease. Even in the absence of other evidence of active disease, with a history of leukemia, this lesion should be considered in the differential diagnosis of collecting system tumors, as recommended therapy is nonsurgical.
 ...
PMID:Intrarenal chloroma causing obstructive nephropathy: CT characteristics. 386 May 21

Localized tumors composed of immature cells of the myelogenous series have been recognized for many years as an uncommon manifestation of granulocytic leukemia. The histologic diagnosis of chloroma (granulocytic sarcoma) may be extremely difficult when the myeloblastic cells are poorly differentiated and the tumor lacks the characteristic green color. The diagnostic difficulty may be further compounded when the granulocytic sarcoma develops before there is peripheral blood or bone marrow evidence of leukemia. Previous criteria for the diagnosis of chloroma have been ambiguous because of the capricious nature of the hydroperoxidase activity and the lack of definitive histochemical criteria. In this case, a combination of Sudan black B and myeloperoxidase histochemical staining and ultrastructural evaluation was applied. The light microscopic histochemical studies suggested the presence of Phi bodies and rods both in the formalin-fixed tumor and in the cells derived from the subsequent pleural effusion; this was confirmed by electron microscopy, which demonstrated the peridicity of the crystalline rod substructure. These observations show that light microscopic histochemical studies can facilitate the diagnosis of granulocytic sarcoma or chloroma in the absence of peripheral blood or bone marrow manifestations of leukemia.
 ...
PMID:Chloroma (granulocytic sarcoma) without evidence of leukemia: facilitated light microscopic diagnosis. 615 60

Symptomatic otologic involvement by leukemic infiltration is unusual, most often occurring in the already-diagnosed leukemic patient as postauricular mass, acute hemorrhagic otitis media, mastoiditis, cranial neuropathy, vertigo, hearing loss, or leptomeningitis. We think ours is the first reported patient whose leukemia presented as atypical mastoiditis and facial paralysis due to granulocytic sarcoma (chloroma). At mastoidectomy, tan lobulated rubbery tumor filled the mastoid antrum and middle ear cleft. Complete remission and full return of facial nerve function was achieved with 2500 R local radiation and systemic chemotherapy. We discuss the role and extent of surgery in atypical acute mastoiditis when unsuspected middle ear and mastoid tumor, with inconclusive intra-operative histopathologic data, is found.
 ...
PMID:Acute myelogenous leukemia presenting as atypical mastoiditis with facial paralysis. 658 14

Chloromas are solid tumours resulting from the localised proliferation of myelogenous leukemia cells, and are frequently responsible for the initial manifestations of acute myelocytic leukemia. We report a patient with a thoracic extradural chloroma whose presentation with acute paraplegia led to the diagnosis of an unsuspected myelocytic leukemia. Early recognition of the etiology of the paraplegia and the underlying systemic involvement with leukemia resulted in an excellent neurological and hematological outcome. The previously described association of the 8:21 chromosomal translocation with a good prognosis is noted in our patient.
 ...
PMID:Extradural chloroma with spinal compression--an unusual presentation of acute myelogenous leukemia. 659 9

Reports from various parts of Africa have documented the epidemiological features of leukaemia as including: infrequent diagnosis of acute lymphoblastic leukaemia (ALL) below the age of 5 years; frequent association of acute myelogenous leukaemia (AML) with chloromas; frequent occurrence, predominantly in women, of chronic lymphocytic leukaemia (CLL) below the age of 50 years. The biological and epidemiological features of leukaemia subtypes were determined in 146 patients who were seen prospectively between July 1978 and June 1982. There were 44 cases of chronic myelocytic leukaemia (CML), 34 of ALL, 33 of AML and 31 of CLL. The age distribution and incidence of CML in Ibadan was similar to those of the Black and White populations of the United States. The incidence of ALL in 0-4 year-old Ibadan children was estimated to be less than one-third and one-tenth of those of Black and White children in the United States, respectively, but the incidence of the disease was similar for the 3 populations in the third quinquennium. AML appeared to be more prevalent in 5-9-year-old Nigerian children than in children in the United States and was associated with chloroma in 5 of 9 (55.6%) children in the age-group. As a group, children with ALL were of significantly higher socio-economic status than those with AML. CLL occurred below 50 years predominantly in women (male:female = 1:6) who were significantly of lower socioeconomic status than their CML counterparts. Male patients predominated (male:female = 5.3) at and above 50 years. Numerous factors indicating a poor prognosis co-existed in all ALL patients, including male sex (25/34), WBC greater than 10(10)/litre (31/34, greater than 10(11)/litre (10/34), L2 or L3 morphology (21/25), periodic acid Schiff (PAS) negativity (15/19) and tissue invasion (15/34), thus giving the impression that ALL in young Nigerians is predominantly of an aggressive and hyperproliferative type. The epidemiological features of ALL and CLL in Africans suggest a role for the influence of life-style in leukaemogenesis while the clinical patterns of these disorders suggest that the biological characteristics differ from those of similar diseases in developed countries.
 ...
PMID:Some biological and epidemiological characteristics of human leukaemia in Africans. 659 2

Leukaemic infiltration of the petrous temporal bone is uncommon with with improved remission rates and longer survival in leukaemia isolated sites of relapse can be expected more frequently. Mastoid chloroma requires treatment with chemotherapy and radiotherapy. Wide-field mastoidectomy and facial nerve decompression are contraindicated.
 ...
PMID:Mastoid chloroma as relapse in acute myeloid leukaemia. 693 47

Granulocytic sarcoma (chloroma) is a localized tumefaction of immature granulocytes that is typically seen in association with myelogenous leukemia. The primitive cell population seen in biopsy material may be misinterpreted as histiocytic lymphoma or other sarcoma unless additional studies are performed. We saw a 36-year-old woman with promyelocytic leukemia in remission who had the signs and symptoms of an acute coalescent mastoiditis. Histologic examination of the surgical specimen, however, demonstrated a granulocytic sarcoma. Our case exemplifies some of the difficulties that may be encountered in the diagnosis of granulocytic sarcoma and illustrates the point that symptoms of an inflammatory process in a patient with a diagnosis of leukemia must be regarded with a degree of suspicion.
 ...
PMID:Granulocytic sarcoma (chloroma) initially seen as acute mastoiditis. 695 53

Acute myeloblastic leukemia is suspected usually because of abnormalities of the peripheral blood or bone marrow. In some cases there may also be an extramedullary focus of leukemic cells called a chloroma or granulocytic sarcoma. On occasion, these tumor masses may precede any evidence of leukemia by months or years. They are often misdiagnosed as lymphomas or granulomas. We present here a case of acute myeloblastic leukemia that was preceded by a granulocytic sarcoma of the clavicle. The initial biopsy of the clavicle was thought to be consistent with Ewing's sarcoma. The patient was treated with systemic chemotherapy prior to gross marrow involvement. He has been in continuous complete remission 34 months after the start of chemotherapy and 44 months after the development of granulocytic sarcoma.
 ...
PMID:Granulocytic sarcoma of the clavicle. 696 4


<< Previous 1 2 3 4 5 6 7 8 9 Next >>