Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 27-year-old woman with proteinuria and normal serum creatinine for 10 years developed chronic lymphocytic leukaemia (CLL) and after further 2 years during treatment with prednisone and chlorambucil a malignant histiocytoma appeared. Free mu-chains were demonstrated in serum, but it is possible that mu-chain disease (mu-CD) and Bence-Jones proteinuria had persisted unrecognized for 12 years, since vacuolated plasma cells were found when the primary bone marrow smear was re-evaluated and no glomerular disorders were found. The clinical findings from the now 11 known cases of mu-CD are reveiwed and the immunochemical findings are reported ain part II (Axelsen et al 1976). The patient's mother died of acute leukaemia at the age of 24. The mother's sister has mammary carcinoma and several members of the mother's line apparently have increased tendency to infections. Of 27 family members, none exhibited immunoglobulin defects, but 10 members of the mother's line had B- as well as T-lymphocytosis and 5 members had leukocytosis.
 ...
PMID:mu-chain disease in a case of chronic lymphocytic leukaemia and malignant histiocytoma. I. Clinical aspects. 17 30

This report concerns a patient with inflammatory fibrous histiocytoma, who in contrast to previous reported cases, has had a long survival (20 years), without evidence of recurrent disease following treatment. An interesting but nonreproducible study was the development of leukemia in 2 of 3 Swiss strain mice following the intraperitoneal injection of a saline extract of the patient's tumor.
 ...
PMID:Inflammatory fibrous histiocytoma: case report. 20 39

A patient is described who developed a malignant inflammatory fibrous histiocytoma of vertebral bone (MFH) 4 months after the onset of acute lymphoblastic leukaemia. This is the first report of the simultaneous occurrence of these two conditions. Similarities to the more frequent occurrence of another histiocytic malignancy, histiocytic medullary reticulosis, following acute lymphoblastic leukaemia, are noted. The usefulness of gallium scanning to monitor the response of this tumour to treatment is demonstrated.
 ...
PMID:Malignant inflammatory fibrous histiocytoma of bone and acute lymphoblastic leukaemia. 299 74

Microtubule poisons such as colchicine, colcemid and vinblastine caused extrusion of nuclei of murine suspension culture cells (mastocytoma p-815 cells, myeloma PU-3 cells, leukemia M1 cells). Enucleation did not follow spontaneously in most cells, but it did occur when the treated cells were centrifuged in Separate-L gradient. These poisons did not induce nuclear extrusion in cells growing in monolayer (L cells, BALB/c 3T3 cells, SV40-transformed BALB/c 3T3 cells, histiocytoma HC-11 cells). Cytochalasin B (CB) that had been reported to cause nuclear extrusion in the cells cultured in monolayer [1] did not induce the extrusion in the suspension culture cells but inhibited the colchicine-induced nuclear extrusion.
 ...
PMID:Extrusion of nuclei of murine suspension culture cells with microtubule poisons. 673 63

Malignant tumors of the pleura are most often diffuse, nethertheless they are sometimes localized. There is an overlap of the radiologic features of the benign and malignant pleural lesions. The differential diagnosis may be difficult, even on histological sample. Imaging allows the diagnosis of pleural involvement, suggests the malignity, guides percutaneous or thoracoscopic biopsies of the pleura, defines extent of the tumor and follows the course of the disease. We will describe the malignant pleural tumors: pleural metastases, pleural involvement of broncho-pulmonary cancer, of lymphoma and leukaemia. Then the rare pleural tumors will be described: malignant pleural fibroma, sarcoma, histiocytoma and hemangiopericytoma.
 ...
PMID:[Other malignant tumors of the pleura]. 1667 Jun 66

The objective of our study was to get epidemiological data in the region of Aarau, Switzerland, about the frequency of cutaneous metastases from visceral malignancies. With a computer search we analyzed all patients with skin metastases from visceral malignancies who had attended our clinic between January 1, 1998, and December 31, 2003. Out of 19 491 patients, 37 had cutaneous metastases from visceral tumours (0,19%): 25 women (67.5%) and 12 men (32.5%) were affected. 19 had breast cancer (51%), 8 sarcomas (21%), 2 leukemia (5%), 2 colorectal cancer, and one each ovary carcinoma, bronchial cancer, prostate cancer, malignant histiocytoma and Non-Hodgkin lymphoma (3%). In 24 cases the primary malignancy was known (65%). In 35% cutaneous metastases were diagnosed at the same time as the primary tumour. Primary malignancies were diagnosed in 54% within the age range of 50-70 years, and 65% of cutaneous metastases were diagnosed within the age range of 50-80 years. In 51% skin metastases were the first site of dissemination. In 49% other known metastases were present (5% locoregional, 38% lymph nodes, 3% brain, 3% lung, 3% liver). Our study documents that cutaneous metastases from visceral malignancies are rare. However, early diagnosis has an impact concerning further treatment and prognosis.
 ...
PMID:[Cutaneous metastases from malignancies which do not originate from the skin. An epidemiological study]. 1909 14

There are different histiocytic diseases in dogs that are characterized by the proliferation of histiocytic cells (macrophages and myeloid dendritic cells). Histiocytic diseases can be devided into neoplastic (cutaneous histiocytoma complex, histiocytic sarcoma, dendritic cell leukaemia) and reactive forms (reactive histiocytosis, haemophagocytic syndrome). All subtypes of the cutaneous histiocytoma complex (cutaneous histiocytoma, metastatic histiocytoma and Langerhans' cell histiocytosis) are of Langerhans' cell origin. Histiocytoma, which is a solitary tumour of the skin in young dogs, shows spontaneous regression in most cases. Occasionally, metastasis to lymph nodes can be seen (metastatic histiocytoma). Only one dog with Langerhans' cell histiocytosis has been described and was euthanized. Histiocytic sarcoma, which arises from myeloid dendritic cells, can be classified as localised histiocytic sarcoma or disseminated histiocytic sarcoma. Another form of histiocytic sarcoma - haemophagocytic histiocytic sarcoma - is derived from macrophages. Histiocytic sarcoma displays a very aggressive clinical course and has a poor prognosis. Breed predispositions have been reported for the disseminated and haemophagocytic form of histiocytic sarcoma in Bernese mountain dogs, Rottweilers and varoiusretrievers. In contrast, reactive histiocytosis (cutaneous and systemic forms) develops by reactive proliferation of interstitial dendritic cells. In systemic histiocytosis, breed predilections are similar to histiocytic sarcoma. Haemophagocytic syndrome develops as a consequence of proliferation of activated macrophages in different tissues. Prognosis in general is moderate to poor and depends on the origin of the underlying disease process.
 ...
PMID:[Reactive and neoplastic histiocytic diseases in the dog]. 2214 27