Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The therapeutic activity of the narcissus residual alkaloid A-2 against Rauscher leukemia has been compared with 10 standard anticancer drugs, and synergistic or additive combination pairs have been selected using a viral leukemia and two transplantable tumor systems. An increased beneficial effect has been demonstrated by a combination of the alkylating and DNA-binding agents and the alkaloid against the three malignant tumors, while a beneficial effect by combining the alkaloid and the antimetabolites (either 6-MP or 5-azacytidine) was seen only against the viral leukemia. The alkaloid has no suppressive activity against cellular immunity as tested by PHA reactivity and allogeneic tumor rejection systems.
 ...
PMID:Combination chemotherapy of Rauscher leukemia and ascites tumors by narcissus alkaloid with standard drugs and effect on cellular immunity. 4 97

The effects of sc administration of 3-methylcholanthrene (MCA), 7,12-dimethylbenz[a]anthracene (DMBA), and benzo[a]pyrene (BP) on spontaneous viral leukemia and subcutaneous sarcoma induction have been studied in weanling C58/J mice. MCA produced significantly more sarcomas at the inoculation site than did DMBA or BP; moreover, it interfered with leukemia development. DMBA produced fewer sarcomas, and the incidence of leukemia was comparable to that found in the controls. BP accelerated the incidence of leukemia, although no sarcomas were produced. When the effect of the age of the mice at the time of MCA treatment on the incidence of leukemia and sarcomas was studied, newborn and weanling mice were found to develop primarily sarcomas, whereas no sarcomas were produced in the 16-week-old mice, and 52-64% of the 16-week-old mice developed leukemia. The reason no sarcomas were found in the C58 mice was apparently different from the reason no sarcomas were found in AKR mice, inasmuch as the AKR mice did not live long enough for sarcomas to develop. Immunologic surveillance may have played a part in the sarcoma suppression in the C58 mouse.
 ...
PMID:Effects of subcutaneous administration of chemical carcinogens on leukemia in C58 mice. 21 41

Attempts have been made to induce viral leukemia in monkeys (Papio hamadryas and Macaca arctoides) by inoculating them with blood from humans with different types of leukemias. In hamadryas baboons, the disease spread horizontally. By today 218 P. hamadryas and 5 M. arctoides monkeys had died of malignant lymphoma. The following viruses have been isolated from sick monkeys: lymphotropic baboon herpes virus (HVP), endogenous baboon C type viruses--xenotropic (BILN), and ecotropic (EVPG). C type oncovirus called "plasmic", which differs immunologically from the endogenous one, was also detected in the blood of sick animals. Altogether 165 sera from baboons, different species of macacas and chimpanzee were examined by the immunofluorescent technique for antibodies to HTLV virus isolated recently from sick humans with T cell leukemia/lymphoma. Antibodies to HTLV virus were detected only in monkeys (P. hamadryas and M. arctoides) with malignant lymphomas or in those which had been in close contact with them. Possible origin of simian HTLV-like virus is discussed. It originates either from leukemic patients or there is a family of primate HTLV like viruses related to the occurrence of leukemia.
 ...
PMID:[Etiological aspects of leukemias in primates including man]. 631 50

Spontaneous viral leukemia, occurring in AKR mice starting at 6 mth, is thymus-dependent, and can thus be abrogated by thymectomy. Two components of the thymic stroma, insoluble thymic fraction (ITF) and soluble thymic factor (STF) previously shown to induce sequential steps in T-cell differentiation, were investigated for their role in the triggering of leukemia. AKR mice, thymectomized at 1 mth received weekly injections of either ITF, STF, ITF + STF or control splenic fractions, and deaths by leukemia were recorded. Mice having received ITF all died at approximately the same rate as the sham-thymectomized untreated controls, while only 20% of the ITF + STF treated mice died. Untreated, STF- or splenic fractions-treated controls all survived. These results are interpreted as indicating that ITF induces a T-cell population sensitive both to leukemic transformation and to STF-mediated differentiation.
 ...
PMID:Triggering of leukemia in thymectomized AKR mice by a membrane fraction of thymic stroma. 660 5

Activity of the lysosomal hydrolases DNAase II, acid RNAase and acid phosphatase was studied in the mouse liver and spleen under developing Friend's viral leukemia. The activity of DNAase II in the liver was considerably increased from the 12th day after inoculation of virus-containing material and reached the maximum by the 20th day of the experiment. The activity of acid phosphatase was changed insignificantly while that of acid RNAase showed no deviations from the control level. A possible role of the lysosomal hydrolases in leukemia development is discussed.
 ...
PMID:[Lysosomal hydrolase activity during development of experimental leukemia]. 739 62

Stability of secondary structure was studied in DNA preparations obtained from healthy and leukemic rats and mice of BALB/c strain by means of estimation of molecular melting point temperature, of the temperature-dependent transition interval and specific viscosity. The secondary structure stability and values of the DNA specific viscosity were decreased in the DNA preparations obtained from liver, spleen tissues and tumors of rats with Shvetz leukemia and from spleen of mice infected by Rausher viral leukemia as compared with these patterns of healthy animals. Strain- and tissue-dependent alterations of the patterns studied were not found.
 ...
PMID:[A comparative study of the stabilized secondary structure and hydrodynamic properties of DNA from healthy and leukemic tissue]. 837 15

The aim of our investigation was to examine the mechanisms of protective features of plaferon LB and fenovit in mice infected with Rausche virus. It was found that in erythroblasts from peripheral blood and spleen, which appeared 12-14 days after infection, the highest percent of determined virus antigens was approximately 47% (range 35,5 to 58,4) which was followed by decrease of the concentration of virus antigens (between 5-12%) in following days and increase of uninfected cells as a result of division of non-contaminated erythroblasts. Mechanism of action of plaferon LB and fenovit was manifested in the reconstitution of mechanisms of apoptosis among erythroblasts, which did not contain synthesized Rausche virus. Impairment of functional activity and antivirus resistance of macrophagal phagocytes are playing an important role not only in the pathogenesis of murine viral leukemia caused by Rausche virus, but also during human leukemia. Correction of functional status of above -- mentioned diseases using plaferon LB and fenovit is presenting as a new and prospective way.
 ...
PMID:[Mechanisms of action of LB-plaferon and fenovin in the cases of Rausche virus leukemia]. 1614 83