Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023418 (
leukemia
)
93,477
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of chloramphenicol on the toxic and therapeutic action of cyclophosphamide was studied on CBA and DBA male mice. The animals were intact or infected with L1210
leukemia
. It was found that the use of chloramphenicol prolonged the life-span of the mice and/or increased the number of the survivals after exposure to the lethal doses of cyclophosphamide. It reduced leukopenia and almost completely protected the animals from macular
canities
developing after administration of cyclophosphamide. The therapeutic effect of cyclophosphamide did not change after the use of chloramphenicol. The mechanisms of the above diverse effects of chloramphenicol on the toxic and therapeutic action of cyclophosphamide and the possibility of the use of chloramphenicol for lowering the cyclophosphamide toxicity in treatment of oncological patients are discussed.
...
PMID:[Effect of chloramphenicol on the toxic and therapeutic actions of cyclophosphane]. 371 19
