Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

JM-V leukemic lymphoblasts were established in cell culture. The cultured cells (JM-VLC cells) were transplantable in young chicks and produced a disease indistinguishable from JM-V lymphoblastic leukemia as initiated by whole-blood inoculation. JM-VLC cells maintained a normal female karyotype through 13 passages in Rhode Island Red cockerels. With the use of JM-V antisera and antisera from birds with naturally occurring Marek's disease (MD), specific antigens were detected on the surfaces of living cells. Intracellular antigens were detected with anti-MD virus sera after cultivation for at least 1 day at 37 degrees C. In spite of the expression of MD antigens, the presence of herpesvirus particles associated with the cultured cells, and the occurrence of foci of multinucleated cells in kidney cultures from chicks inoculated with cellfree preparations of JM-VLC cells, the pathologic potential of the cultured cells was that of JM-V leukemia.
 ...
PMID:Lymphoproliferative diseases of fowl: JM-V leukemic lymphoblasts in cell culture. 19 70

The presence of virus-specific RNA in commercial chick embryos and its lack in chick embryos of leukemia-free chicken farm of the USSR AMS Oncological Research Center as well as in cell cultures from RIF-free chicken infected with Marek's disease virus was demonstrated by hybridizationof 3H-DNA-product of Rous sarcoma virus synthesized in vitro in the presence of actinomycin D with the total preparation of cellular RNA.
 ...
PMID:[Study of the synthesis of Rous virus-specific RNA in chick embryo cells]. 20 14

Numbers of B, T and total lymphocytes, monocytes, heterophils, eosinophils and basophils have been examined in the peripheral blood of chickens between 2 and 42 days after infection with Marek's disease virus. During the stage of the acute restrictively productive virus infection of lymphoid tissues at 2-9 days after infection, absolute numbers of B cells, T cells, total lymphocytes and heterophils were increased, those of monocytes and eosinophils were decreased, and those of basophils were unchanged. The lymphoproliferative phase of the disease, from 21-42 days after infection leading to lymphoma formation, was accompanied by an increase in T cells, total lymphocytes and possibly eosinophils, and a decrease in B cells, monocytes, heterophils and basophils. The T-cell increase following infection occurred only in female birds, and there were more lymphomas in females than in males. The increase in lymphocytes in the blood of six birds with leukemia was mainly due to an increase in T cells, but in one bird B cells were also increased. Blast cells and atypical lymphoid cells were increased in leukemic birds. Regression coefficients were calculated between different pairs of leukocytes in infected and uninfected birds at different stages of the disease. Particularly noteworthy were the associations between B and T cell numbers, which indicated constant proportions of these cells irrespective of total numbers, possibly due to a common control mechanism.
 ...
PMID:Sequential changes in the numbers of B and T lymphocytes and other leukocytes in the blood in Marek's disease. 78 60

Promiscuous transcriptional activity of the reticuloendotheliosis virus (REV) long terminal repeat (LTR) was detected in transient expression assays using LTR-chloramphenicol acetyltransferase-encoding gene chimeras, and cells of diverse species and tissue type; levels of expression from two different REV LTRs correlate with reports of pathogenicity of the respective viruses in vivo. REVs do not encode a transactivator targeted to the viral LTR, and cells infected with Marek's disease virus, a herpesvirus with an overlapping host range, do not express factors that preferentially enhance expression from REV or avian sarcoma/leukemia virus LTRs. REV LTRs work efficiently in human lymphoid cells, and are viable alternatives to promoters commonly used for expression of cloned genes. They may also prove useful in the identification of new, ubiquitous cellular transcription factors.
 ...
PMID:Reticuloendotheliosis virus long terminal repeat elements are efficient promoters in cells of various species and tissue origin, including human lymphoid cells. 133 12

We report a case of adult T-cell leukemia presenting with sensorimotor polyneuropathy with persistent severe pain. The patient died without treatment after 4 months. Autopsy showed infiltration of peripheral nerves by leukemia with no involvement of the CNS. This case closely resembles Marek's disease of fowls, a virus-induced T-cell lymphoma associated with neurolymphomatosis.
 ...
PMID:Human neurolymphomatosis by adult T-cell leukemia. 278 34

Several immunological, hematological, and pathological responses associated with Marek's disease were determined. Four-week-old Marek's disease-infected and control chickens were injected with Salmonella pullorum antigen. About one-half of all infected chickens tested were unresponsive to antigenic challenge. Antibody titers in responsive infected chickens were significantly depressed at 1 and 2 weeks post-inoculation when compared to controls. Total white blood cell counts of control and control-antigen chickens were significantly lower than counts in infected chickens. Based on response to antigenic challenge, 24% of the responsive group had leukemia compared to 54% of the unresponsive chickens. The predominant cell populations in these two groups responsible for the mononuclear cell leukemia were large lymphocytes and blast cells. These cell increases were significantly greater in unresponsive chickens. Also, transient increases in the granulocytic elements were observed in some infected chickens. Large fluctuations in hematocrit values were observed in Marek's disease-infected chickens. As many as 30% of the infected chickens were anemic throughout the testing periods. Infected chickens which did not receive antigen had lower incidences of mortality and gross lesions than similarly treated chickens which did receive antigen. In addition, those chickens which were unresponsive to antigenic challenge had a higher mortality rate and increased percentages of gross lesions when compared with responsive chickens.
 ...
PMID:Correlation of immunological responsiveness with lymphocyte changes in chickens infected with Marek's disease. 529 90

Contamination of Japanese quail, strain Pharaoh, cell culture with oncogenous and infectious avian viruses was studied. The susceptibility of the embryonal cell cultures of the Japanese quail, strain Pharaoh, to measles, parotitis and fixed rabies viruses was also determined. It was found that the sera of pubertal quails had no antibody to Rous sarcoma virus (RSV), strains Brian, RSV (RAV-1), Schmidt-Ruppin, Carr-Zilber, as well as to Marek's disease and Newcastle disease viruses. No reverse transcriptase activity was detected in the embryonal alantoic fluid of this avian species. The quails were less susceptible, as compared to the chicken, to Schmidt-Ruppin and Carr-Zilber strains of RSV. Measles, parotitis and fixed rabies viruses reproduced actively in the Japanese quail, Pharaoh strain, embryonal cell cultures. It is suggested that the embryonal cell cultures of this avian species can be used as a leukemia-free substrate for experimental studies and manufacturing of viral vaccines.
 ...
PMID:["Pharaoh" line culture of Japanese quail cells as a leukosis-free system for virus reproduction]. 625 36

The article presents the data obtained by the authors in studies of virus-viral co-cancerogenesis, the interaction between some non-oncogenic viruses and well-known oncogenic viruses, the results of co-cancerogenic effect Marek's disease herpesvirus with the avian leukemia virus and the possibility of phenotype mixing between oncornaviruses belonging to different species in nature.
 ...
PMID:Virus-viral co-cancerogenesis and the other viral interactions. 625 99

Spleen cells from 8-week-old, nonimmunized donor chickens can transfer resistance to a supralethal dose of the JMV leukemia line of Marek's disease (MD) to newly hatched, highly susceptible, histocompatible recipients. The population of cells transferring resistance has previously been shown to be non-T, non-B, and nonmacrophage in nature. We present data here showing that heavily x-irradiated spleen cells were unable to protect recipients from leukemia challenge. Both complement receptor-bearing and -lacking cells could confer resistance to newly hatched recipients. Fc receptor-bearing cells conferred significant protection to recipients, whereas spleen cells depleted of Fc receptor-bearing cells were unable to protect chickens from death after JMV challenge. This indicates that the population of spleen cells, which is moderately radiosensitive and which possesses Fc receptors, is responsible for the transfer of natural resistance to the malignancy in vivo.
 ...
PMID:Transfer of natural resistance to Marek's disease (JMV) with nonimmune spleen cells. II. Further characterization of protecting cell population. 739 77

Marek's disease virus transactivates promoters of avian leukemia and sarcoma viruses. In this study, a series of RSV-LTR promoter deletion mutants were used to map sites within the LTR important for MDV-mediated transactivation. MDV-responsive elements within RSV-LTR promoters were localized to a 28-bp segment (nucleotides -109 to -137) which contains a GGTGG pentanucleotide repeat element (PRE). Nuclear extract proteins from uninfected cells bound to the RSV PRE in a sequence-specific manner. Extracts from cells infected with MDV produced novel, sequence-specific complexes with RSV PRE probes. Transactivation in other herpesvirus-retrovirus systems has been shown to depend, at least in part, on expression of herpesvirus immediate-early genes. In this report, we demonstrate that MDV ICP4 is capable of transactivating RSV-LTR promoters containing an intact PRE region. Transactivation with an isolated MDV ICP4 gene expressed from its cognate promoter was less efficient than with intact MDV, suggesting that other MDV-encoded factors are likely to play a role in MDV-mediated transactivation of RSV-LTR promoters. RSV-LTR promoters lacking a PRE region were not efficiently transactivated by MDV ICP4. We conclude that MDV ICP4 may be at least partially responsible for transactivation of RSV-LTR promoters and that this transactivation is likely to be dependent upon presence of a PRE region within RSV-LTR promoters.
 ...
PMID:Interactions between Marek's disease virus encoded or induced factors and the Rous sarcoma virus long terminal repeat promoter. 811 31


1 2 3 4 Next >>