Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lactobacillus species are a commensal flora of the human gastrointestinal and the female genitourinary tract. Lactobacilli especially the rhamnosus species, are common components of commercial probiotics. They are rarely associated with pathology in immunocompetent people, but they have been known to cause dental caries, bacteremia, and endocarditis in patients with suppressed immune function. Cases of Lactobacillus bacteremia have been reported in patients with acute myeloid leukemia, large granular lymphocytic leukemia, and in transplant recipients. In this article, we report a strange case of recurrent Lactobacillus bacteremia causing multiple episodes of fever of unknown origin in a patient with leukemia. This report is unique as Lactobacillus is not recognized as a common source of bacteremia. Moreover, the source of the bacillus continued to elude us even after extensive investigation.
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PMID:Recurrent Lactobacillus Bacteremia in a Patient With Leukemia. 2920 52

The burden of oral health diseases in children with leukaemia and the impact of cancer treatment on their oral health have not been studied in Sudan. The present study assesses the oral health status of leukemic children through measuring caries experience, gingival status, oral hygiene status and mucositis. It also explores the association between the oral health status of children with leukaemia and their parental education, oral hygiene habits, treatment stage and type of leukaemia. A cross sectional hospital-based study was conducted at the Radiation and Isotope Center Khartoum, Khartoum State. A total of 87 children were included in this study. Data were collected by interviewer questionnaire and clinical examination. The oral health status revealed high prevalence of untreated dental caries (37.9%) and the majority (67.9%) of children had poor oral hygiene. Nearly, all children with leukaemia (93.1%) had never visited a dental health facility in their lives. Regarding the treatment stages of leukaemia, the severity of dental caries was found to be more significant in the maintenance phase, while oral mucositis was more significant in the induction phase.
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PMID:Oral health status and its determinants in children with leukaemia at the Radiation and Isotope Center Khartoum, Khartoum State, Sudan. 3196 37

Leukemia is the cancer of blood cells and bone marrow and it is the most common cancer in children. The cause of acute lymphocytic leukemia is unknown, but many predisposing risk factors could be associated, such as an exposure to radiation, chemical or viral infections. A six-year-old boy was presented with multiple carious teeth and severe pain related to his lower left teeth. Regarding medical history, the child was diagnosed with acute lymphocytic leukemia and after consultation with patient's physician; dental treatment was planned to be accomplished under general anesthesia. The aim of treatment was to eliminate sources of infections, restore carious teeth, relief pain, and improve oral hygiene and patient's parents' education regarding general and oral health. Full-mouth rehabilitation was accomplished after preparing the patient with pediatric hematology/oncology team under general anesthesia. During recall visits, good oral hygiene and caries-free teeth were obtained. It is important to have solid knowledge regarding the medical conditions, the necessary consultations with medical subspecialties and the appropriate timings for treatment.
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PMID:Dental Rehabilitation of a Child with Acute Lymphocytic Leukemia: A Case Report. 3244 80


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