Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Russian State Medical and Dosimetric Register (RSMDR) of subjects exposed to radiation due to the Chernobyl accident and a radiation epidemiological analysis of the data collected are described. At present, RSMDR covers 435,000 persons including 152,000 participants in the liquidation of the accident consequences (liquidators). Predictive estimates (based of the models recommended by the International Commission of Radiation Protection) and the actual data obtained 9 years after the accident are compared. It has been found that within 20 years after radiation in a cohort of liquidators an attributive risk for leukemia and for solid cancers will be 23.6 and 2.8%, respectively. The actual data after 10 years correspond with the predictive estimates. According to disability and morbidity rates, the 1986-1987 liquidators represent a high-risk group. Radiation epidemiological examinations for thyroid cancer in children (at the moment of the Chernobyl accident) were made in the Bryansk and Kaluga Regions. The relative risk for detected cancers was ascertained to be 7.15. This signifies that about 90% of the thyroid cancers detected are caused by a radiation factor.
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PMID:[The results of medical and dosimetric research on the population and on those who worked in cleanup subjected to radiation exposure as a result of the Chernobyl catastrophe]. 892 39

We studied 1771 patients treated for a thyroid cancer in two institutions. None of these patients had been treated with external radiotherapy and 1497 had received (131)I. The average (131)I cumulative activity administered was 7.2 GBq, and the estimated average dose was 0.34 Sv to the bone marrow and 0.80 Sv to the whole body. After a mean follow-up of 10 years, no case of leukaemia was observed, compared with 2.5 expected according to the coefficients derived from Japanese atomic bomb survivors (P = 0.1). A total of 80 patients developed a solid second malignant neoplasm (SMN), among whom 13 developed a colorectal cancer. The risk of colorectal cancer was found to be related to the total activity of (131)I administered 5 years or more before its diagnosis (excess relative risk = 0.5 per GBq, P = 0.02). These findings were probably caused by the accumulation of (131)I in the colon lumen. Hence, in the absence of laxative treatment, the dose to the colon as a result of (131)I administered for the treatment of thyroid cancer could be higher than expected from calculation of the International Commission on Radiological Protection (ICRP). When digestive tract cancers were excluded, the overall excess relative risk of second cancer per estimated effective sievert received to the whole body was -0.2 (P = 0.6).
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PMID:Leukaemias and cancers following iodine-131 administration for thyroid cancer. 904 33

Ten years have passed since the Chernobyl disaster. Five years ago, reports began to appear suggesting an increase in the frequency of thyroid cancer in children living or born in the areas with highest exposure to radioactive contamination. During the past year, data have been published, presented, or submitted that demonstrate the magnitude of the increase in incidence. No increase in childhood leukemia or other cancers has been documented. However, anxiety about the future persists. A rapid government response, including the distribution of potassium iodide to the highest-risk groups, pregnant women and young children, could have prevented the majority of the cases of thyroid cancer.
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PMID:Childhood cancer 10 years after the Chernobyl accident. 908 56

This work focuses on the direct epidemiological assessment of the risks of radiation-induced leukaemia and thyroid cancer in emergency workers (EW) after the Chernobyl accident. The Russian National Medical Dosimetric Registry (RNMDR) contains data for 168,000 EW as of January 1, 1996. The analysis relates to 48 leukaemias and 47 thyroid cancers, diagnosed and verified. Radiation risks are estimated by comparing the EW data with national data for a male population of the same age distribution. For leukaemia, an excess relative risk per Gy (ERR/Gy) of 4.30 (95% CI: 0.83, 7.75) is obtained, while the excess absolute risk per 10(4) person-years (PY) Gy (EAR/10(4)PY Gy) is found to be 1.31 (95% CI: 0.23, 2.39); for thyroid cancer an ERR/Gy of 5.31 (95% CI: 0.04, 10.58) is obtained, and an EAR/10(4)PY Gy of 1.15 (95% CI: 0.08, 2.22).
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PMID:Leukaemia and thyroid cancer in emergency workers of the Chernobyl accident: estimation of radiation risks (1986-1995). 912 93

Scientific results obtained within the WHO International Programme on the Health Effects of the Chernobyl Accident (IPHECA) have confirmed the increase of thyroid cancer cases in children who were exposed to radiation due to the accident in 1986. In the zones under surveillance in Belarus, the Russian Federation and Ukraine, the general morbidity for leukaemia and related diseases did not undergo a significant change after the accident. Accident recovery workers ("liquidators") are an especially high-risk group and need further medical follow-up.
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PMID:Main scientific results of the WHO International Programme on the Health Effects of the Chernobyl Accident (IPHECA). 917 Feb 37

There is concern about possible association between PUVA treatment and an increased risk of noncutaneous cancer. An alteration in the risk of cancer among persons with psoriasis has also been postulated. To test this hypothesis, for nearly two decades we have prospectively followed 1380 patients who first began PUVA treatment for psoriasis in 1975-1976. We compare the risk of noncutaneous cancer in our cohort with that expected based on general population incidence rates. The overall risk of noncutaneous cancer was nearly identical to that expected in general population. For three separate sites, we noted significant increases: thyroid cancer (RR = 3.57, 95% CI = 1.16-8.34), breast cancer (RR = 1.81, 95% CI = 1.19-2.64), and central nervous system neoplasms (RR = 2.80, 95% CI = 1.13-5.57). Since 1987, however, the risk of central nervous system neoplasms has not been elevated (RR = 0.00, 95% CI = 0.00-3.35) and the relative risk of breast cancer was lower than in the prior decade and not statistically significant. There was no association between higher levels of exposure to PUVA and the risk of any of these cancers. We did not detect any significant increase in the risk of lymphoma or leukemia. Our study does not support the hypothesis that long-term PUVA treatment increases the risk of noncutaneous cancer.
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PMID:Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996. 918 18

It is both ethically and economically desirable to restrict the use of diagnostic medical radiation to only those who will benefit from it. However, patients should not refuse diagnostic tests based on an exaggerated estimation of the risks because most of these tests involve low doses of radiation. It is probable that the risks derived from studies of the atomic bomb survivors, who were exposed to high doses of radiation, overestimate the risks at low doses. No evidence of thyroid cancer, leukaemia or non-Hodgkin's lymphoma has been found in patients exposed to diagnostic levels of ionising radiation. For most diagnostic tests, the risks arising from the radiation exposure are too small to be observed and the benefits will almost always outweigh the risk.
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PMID:What are the risks of diagnostic medical radiation? 950 22

The severe nuclear accident at Chernobyl in 1986 resulted in the worst reported accidental exposure of radioactive material to free-living organisms. Short-term effects on human populations inhabiting polluted areas include increased incidence of thyroid cancer, infant leukaemia, and congenital malformations in newborns. Two recent studies have reported, although with some controversy, that germline mutation rates were increased in humans and voles living close to Chernobyl, but little is known about the viability of the organisms affected. Here we report an increased frequency of partial albinism, a morphological aberration associated with a loss of fitness, among barn swallows, Hirundo rustica, breeding close to Chernobyl. Heritability estimates indicate that mutations causing albinism were at least partly of germline origin. Furthermore, evidence for an increased germline mutation rate was obtained from segregation analysis at two hypervariable microsatellite loci, indicating that mutation events in barn swallows from Chernobyl were two- to tenfold higher than in birds from control areas in Ukraine and Italy.
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PMID:Fitness loss and germline mutations in barn swallows breeding in Chernobyl. 933 97

The Chernobyl accident in 1986 had a major ecological impact, with the bulk of the radioactive contamination affecting Belarus, the Ukraine and Russian Federation. Belarus has a nationwide general cancer registry that dates back to 1965, which allows a comparison of cancer incidence rates from before and after the accident. Preliminary analysis indicates that there has been an increased incidence of all cancers, with thyroid cancer accounting for most of that change. When cancer incidence data from Belarus are compared to data from the U.S., there is a higher incidence of thyroid cancer and a slightly higher incidence of Hodgkin's disease and non-Hodgkin's lymphoma in Belarus, but a lower reported incidence of leukemia and brain tumors. The Belarusian State Cancer Registry is being used as a foundation for the development of a more comprehensive childhood cancer registry.
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PMID:Epidemiology of childhood cancer in Belarus: review of data 1978-1994, and discussion of the new Belarusian Childhood Cancer Registry. 936 8

Information about the consequences of human exposure to radiation in the former Soviet Union has recently become available. These data add new insights and provide possible answers to several important questions regarding radiation and its impact on occupational and public health. The 1986 Chernobyl accident initiated a major and early increase in childhood thyroid cancer that resulted from ingestion of iodine-131 (131I) by young children living in the most heavily contaminated areas of Belarus, Ukraine, and Russia. No significant additional cancer or other adverse medical effects have yet been reported in the affected populations and among clean-up workers. Major psychological stress independent of radiation dose has been observed in those people thought to be exposed. During the early days of the atomic energy program in the former Soviet Union, some unfortunate events occurred. The country's first atomic test in Semipalatinsk in 1949 exposed over 25,000 people downwind from the blast to significant doses of fission products, especially 131I. During the late 1940s and the early 1950s nuclear material production facilities were developed near Chelyabinsk in the South Ural Mountains, which resulted in major releases into the environment and significant overexposures for thousands of workers and nearby populations. Chronic radiation sickness was observed early in exposed workers, and increases in leukemia and other cancers were also reported. The series of plutonium inhalation-related lung cancers and fatalities among workers exposed in that first decade appears to be unique. Long-term consequences of chronic radiation sickness and four decades of follow-up are being described for the first time. Villagers downstream from the plant consumed high levels of 137Cs and 90Sr and, it is reported, manifested increases in leukemia from internal and external exposures. Although the 40-year databases for retrospective dosimetry epidemiology studies are just beginning to be integrated and evaluated, preliminary evaluations suggest that there may be graded, significant dose-rate amelioration factors for cancer and leukemia risks in workers and the general population relative to the risk data on the Japanese atomic bomb survivors. Even for plutonium-induced lung cancers in workers, such a dose-rate effect may be evident. These experiences give us insight into the consequences of protracted radiation at high and low doses and rates. If these findings are validated and confirmed, they can provide information that reduces some of the uncertainties in retrospective radiation dosimetry and radiation risk estimates (especially for low-level, chronic exposures) for activities related to medicine as well as the handling of nuclear materials and nuclear facility decommissioning, decontamination, and demilitarization.
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PMID:The Russian radiation legacy: its integrated impact and lessons. 946 49


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