Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023418 (
leukemia
)
93,477
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The gene,
structural maintenance of chromosomes 4
(
SMC4
) plays important role in chromosomes condensing and mitotic sister chromatid segregation, which has been revealed in regulating multiple cancer development and carcinogenesis. However, the role of
SMC4
in acute myeloid leukemia (AML) propagation and its function in regulation of
leukemia
stem cells (LSCs) is not yet clear. Using an MLL-AF9 induced AML mouse model, we demonstrated that down modulating of
SMC4
expression could prolong the survival time of AML mice. Furthermore, we found that knockdown
SMC4
expression decreased the proportion of LSCs and affected its
leukemia
-initiating capacity. Cell cycle assay demonstrated that more LSCs were arrested in G0 phase by
SMC4
knockdown. This activity was accompanied by increased expression of the Cdkn1a (P21) and Cdkn1b (P27) as well as decreased expression of CDK4. Therefore, our study revealed the critical role of
SMC4
during AML progression and provided new insights into the mechanism of LSC maintenance.
...
PMID:Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia. 2904 83
