Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023380 (lethargy)
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Human Gene/Protein
IBtk 10.4
intelectin 2 9.9
RNA binding motif protein 20 9.6
Kinesin light chain 9.4
goa 9.1
CACNB4 9.0
HMGCL 8.9
intrinsic factor-cobalamin receptor 8.9
3-hydroxy-3-methylglutaryl-CoA lyase 8.8
IER3IP1 8.7
CUBN 8.6
MICE 8.6
mitochondrial 3-oxoacyl-CoA thiolase 8.5
DNAJA4 8.5
PCCB 8.5
FLAD1 8.4
NDUFA5 8.4
SLC25A15 8.4
chaperonin containing t-complex polypeptide 1 8.4
Cacng2 8.4
HMGCS2 8.3
isovaleryl-CoA dehydrogenase 8.3
Medium-chain acyl-CoA dehydrogenase 8.3
ATP5D 8.1
TBX19 8.1
lysosomal acid beta-galactosidase 8.0
DHTKD1 7.9
CML28 7.9
N61 7.8
CD11d 7.8
CA5 7.7
CYP2F 7.6
PCCA 7.6
ABC-C 7.5
propionyl-CoA carboxylase 7.5
3-hydroxy-3-methylglutaryl CoA 7.5
infantile malignant osteopetrosis 7.4
HMG-CoA lyase 7.4
N-acetylglutamate synthetase 7.4
ACADM 7.4
ClC-K1 7.3
HLA-DNA 7.3
p-hydroxyphenylpyruvate dioxygenase 7.3
ISD11 7.2
HSPH1 7.2
CYB5R3 7.1
BREAST 7.1
cblB 6.9
MAGE-C2 6.9
HADHB 6.9
Cps1 6.9
mitochondrial acetoacetyl-CoA thiolase 6.9
ETFDH 6.9
RBM20 6.9
MMAA 6.9
EIF2B5 6.9
NADH cytochrome b5 reductase 6.9
NFU1 6.9
KF-1 6.8
biotinidase 6.8
CA V 6.8
Kidd blood group 6.7
DNAJA1 6.7
ICAM3 6.7
HADHA 6.7
Citrin 6.7
TCN2 6.6
ANKRD11 6.6
SSADH 6.6
SCNN1A 6.6
galactose-1-phosphate uridyl transferase 6.5
AC9 6.5
ANXA5 6.5
inhibitor of Bruton's tyrosine kinase 6.5
Connectin 6.5
ASS1 6.5
adenosine monophosphate deaminase 6.5
MMACHC 6.5
Interferon regulatory factor 4 6.4
methylmalonyl-CoA mutase 6.4
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Disease
Lobular dissecting hepatitis 12.4
Acquired hydrocephalus 12.4
Bacterial aneurysm 12.4
Coryzal symptoms 12.4
Minor depressive disorder 11.4
Classical Maple Syrup Urine Disease 11.4
Hexamitiasis 11.4
Situs inversus abdominalis 11.4
Gallbladder infection 11.4
Chronic frontal sinusitis 11.4
Intestinal strangulation 10.9
Light chain myeloma 10.9
Irreversible renal failure 10.9
Gallbladder mucocele 10.9
Adenoviral pneumonia 10.9
naegleriasis 10.9
Familial nephropathy 10.9
Metaphyseal osteopathy 10.9
Beta-ketothiolase deficiency 10.6
Cobalamin C disease 10.4
Centrilobular hepatic necrosis 10.4
Peripheral vestibular disease 10.1
Acute dermatitis 10.1
Intractable vomiting 10.1
Pituitary infarction 10.1
Visceral gout 10.1
protozoal meningoencephalitis 10.1
Anterior communicating artery aneurysm 9.9
Chronic gastric volvulus 9.9
Endocardiosis 9.9
Gastroesophageal intussusception 9.9
Idiopathic intussusception 9.9
Lymphocytic-plasmacytic enteritis 9.6
Regenerative anemia 9.6
growth hormone secreting adenoma 9.6
Intestinal lymphoma 9.6
C cell adenoma 9.6
Adrenal carcinoma 9.6
Intracranial venous thrombosis 9.6
hyperglycinemia 9.5
Transtentorial herniation 9.4
mesothelial neoplasm 9.4
Acute renal impairment 9.4
Holocarboxylase synthetase deficiency 9.4
Proximal myopathy 9.4
Lipoamide dehydrogenase deficiency 9.4
Gastrointestinal anthrax 9.4
Cytauxzoonosis 9.4
Affect lability 9.3
undifferentiated carcinoma of unknown primary 9.3
HMG-CoA lyase deficiency 9.1
Basophilic Leukemia 9.1
Fish Diseases 9.1
Lipemia retinalis 9.1
epileptic twilight state 9.0
Uremic encephalopathy 9.0
hypoadrenocorticism 8.9
Cortical laminar necrosis 8.9
amentia 8.9
CPS deficiency 8.8
Orofacial dyskinesia 8.7
Airsacculitis 8.7
Hypervitaminosis D 8.7
Candida pyelonephritis 8.6
Francisella infections 8.6
splenitis 8.6
Toxicosis 8.6
Fourth nerve palsy 8.5
Ehrlichia canis infection 8.5
MCAD deficiency 8.5
hyperproteinemia 8.5
methionine synthase deficiency 8.4
fructosuria 8.4
Haemonchosis 8.4
Cough syncope 8.4
hypochloremia 8.4
Lactational amenorrhea 8.4
Oropouche fever 8.4
Persistent vegetative state 8.4
Plasma cell neoplasm 8.4
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Symptom
lethargy 12.4
Multiple symptomatology 11.4
Bulging fontanelle 10.9
decreased skin turgor 10.3
abnormal urination 10.1
dysorexia 9.7
lipuria 9.6
Chills and fever 9.1
Brudzinski's sign 9.0
eye discharge 8.9
labored breathing 8.9
Kernig's sign 8.8
decreased appetite 8.6
prickling sensation 8.5
anorexia 8.4
cracked lips 8.3
Dribbling 8.2
Mental status changes 8.2
Mucosal hyperplasia 8.2
dry throat 8.1
emaciation 8.0
muscular incoordination 7.9
ketonuria 7.9
polydipsia 7.9
abnormal breathing 7.9
Soft stools 7.9
enanthema 7.7
Sore 7.6
tachypnea 7.6
abnormal taste 7.5
pallor 7.5
GI irritation 7.5
facial droop 7.5
prostration 7.4
Pain and tenderness 7.4
strangury 7.4
polyuria 7.3
adipsia 7.2
catatonia 7.1
asterixis 7.1
Todd's paralysis 7.1
vomiting 7.0
hypotonia 7.0
carpopedal spasm 6.9
loss of equilibrium 6.9
neck stiffness 6.9
nasal discharge 6.9
hypersomnia 6.9
stomach cramps 6.9
meningism 6.9
postpartum pain 6.7
Severe diarrhea 6.6
Infantile colic 6.6
hypoproteinemia 6.5
hepatomegaly 6.5
astasia 6.5
retching 6.5
tonic-clonic seizure 6.5
dry skin 6.5
lightheadedness 6.4
renal pain 6.4
cyanosis 6.4
ataxia 6.4
sleepiness 6.3
night sweats 6.3
dark urine 6.3
lassitude 6.3
dyschezia 6.2
forgetfulness 6.2
feeling tired 6.2
No toxic effect 6.1
excessive sweating 6.1
frequent urination 6.0
stuffy nose 6.0
gumma 5.9
jaw pain 5.9
arm weakness 5.9
incoordination 5.9
weakness 5.9
colic 5.9
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Drug
Metacresol 11.4
Liskantin 11.4
Tribromomethane 10.9
Methyldopate 10.9
Butamirate citrate 10.9
Elsamitrucin 10.9
Fostedil 10.1
Loxapin 9.9
Cnidii rhizoma 9.7
Loxapine succinate 9.6
Rubitecan 9.4
Dirlotapide 9.4
Propoxyphene napsylate 9.4
Ilmofosine 8.7
Selenium sulfide 8.6
Methsuximide 8.6
Dantrium 8.1
Smallpox vaccine 8.1
Edatrexate 8.1
Bendrofluazide 8.1
Deferoxamine mesylate 7.9
Artane 7.9
Oxyphenbutazone 7.9
Remeron 7.9
Aldomet 7.8
Oxyphenbutazone 7.8
Cardura 7.7
Alacepril 7.7
Cardura 7.7
Digibind 7.5
Artane 7.4
Belladonna 7.4
Gadobenate dimeglumine 7.3
Pleconaril 7.1
Visken 7.0
Leukine 7.0
Triprolidine 6.8
Pralidoxime 6.8
Stiripentol 6.7
Humalog 6.7
Swainsonine 6.7
Methergin 6.6
Doramectin 6.6
Atabrine 6.6
PAPM/BP 6.5
Dextropropoxyphene 6.4
Keppra 6.4
Narcan 6.2
Catapres 6.2
Sumatran 6.2
Trental 6.2
Methyldopa 6.1
Sodium valproate 6.1
Zyban 6.1
Lepirudin 6.1
Cobalamin 6.0
Valproic Acid 5.9
Sodium benzoate 5.8
Mirtazapine 5.7
Trilostane 5.7
Dantrolene sodium 5.7
Cinnarizine 5.6
Intron A 5.6
Dexfenfluramine 5.5
Magnesium sulfate 5.4
Intron A 5.4
CTRX 5.4
Intron A 5.4
Hyperforin 5.4
Triazolam 5.4
Sucralfate 5.3
Parlodel 5.3
Vitamin B12 5.2
Fenbendazole 5.1
Tianeptine 5.1
Nadolol 5.1
Dexrazoxane 5.0
Atipamezole 5.0
Bentonite 5.0
Gatifloxacin 4.9
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Enzyme
3-hydroxy-3-methylglutaryl-CoA lyase 8.5
isovaleryl-CoA dehydrogenase 8.5
4-nitrophenol hydroxylase 7.7
propionyl-CoA carboxylase 7.6
glycine N-acyltransferase 7.4
propionyl-CoA carboxylase 7.3
propionyl-CoA synthetase 7.3
biotinidase 6.8
methylmalonyl-CoA mutase 6.6
HMG-CoA synthase 6.1
thiamine pyrophosphokinase 5.8
acyl-CoA dehydrogenase 5.8
carbamoylphosphate synthetase 5.8
N-acetylglutamate synthase 5.7
EC 2.7.7.9 5.5
guanidinoacetate methyltransferase 5.3
tripeptidyl peptidase 5.3
N-acetylglutamate synthase 5.2
glycine decarboxylase 4.9
ornithine transcarbamylase 4.9
acyl-CoA dehydrogenase 4.8
glutaryl-CoA dehydrogenase 4.7
pyruvate carboxylase 4.7
4-hydroxyphenylpyruvate dioxygenase 4.6
fumarylacetoacetate hydrolase 4.3
succinic semialdehyde dehydrogenase 4.2
aspartate aminotransferase 4.2
acetoacetyl-CoA thiolase 4.1
3-hydroxyacyl-CoA dehydrogenase 4.1
argininosuccinate synthetase 4.0
alanine aminotransferase 4.0
sorbitol dehydrogenase 4.0
ACAT 3.9
lactate oxidase 3.9
lactic acid dehydrogenase 3.9
mannosidase II 3.8
creatine kinase 3.8
GABA transaminase 3.8
arginine kinase 3.7
lactic acid dehydrogenase 3.6
botulinum neurotoxin 3.6
lactic acid dehydrogenase 3.6
AST 3.5
NADH-cytochrome b5 reductase 3.4
tryptophan hydroxylase 3.2
arylsulfatase A 3.2
phosphoglucomutase 3.0
3-hydroxyacyl-CoA dehydrogenase 3.0
AMP deaminase 3.0
gamma-glutamyl transpeptidase 3.0
E-2 3.0
ornithine aminotransferase 2.9
transpeptidase 2.9
glycerol kinase 2.9
alpha-mannosidase 2.9
FAST 2.9
glutamate synthase 2.9
glutamate synthase 2.8
glutamate synthase 2.8
dihydropyrimidine dehydrogenase 2.8
alkaline phosphatase 2.8
methionine synthase 2.8
thromboplastin 2.8
KAT 2.7
LasR 2.6
asparaginase 2.6
methionine synthase 2.6
GAS 2.5
adenylate kinase 2.5
carboxylesterase 2.5
glucose-6-phosphatase 2.4
pyruvate kinase 2.4
DOPA decarboxylase 2.4
NADH dehydrogenase 2.4
sulfatase 2.4
glutamate decarboxylase 2.4
cytochrome oxidase 2.3
ADH 2.3
CPT 2.3
21-hydroxylase 2.3
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Compound
1-bromo-2-fluoroethane 12.4
Suberylglycine 12.4
2-Amino-5-nitrophenol 11.4
Juliflorine 11.4
Ammelide 10.4
Ethyl methacrylate 10.4
2-Amino-4-nitrophenol 9.9
butanal oxime 9.6
Fenpyroximate 9.4
Tetrahydrozoline 9.3
Naphthol AS-D 9.3
Thaliblastine 9.1
Doxepin hydrochloride 8.7
Cyclobenzaprine 8.5
2-furaldehyde semicarbazone 8.4
Fludrocortisone acetate 8.4
Naphthol AS-D 8.4
Metaxalone 8.4
Quazepam 8.3
3-O-Methyldopa 8.3
Methacrylonitrile 8.3
Neomycin sulfate 8.2
p-Nitrobenzoic acid 8.2
Indocin 8.1
Neomycin sulfate 8.1
Aurin 7.9
Aminoglutethimide 7.9
Lysergic acid 7.7
C8H18 7.7
Hexachlorobutadiene 7.5
Chloranil 7.5
Nickel sulfate 7.4
Merbarone 7.4
Tiazofurin 7.4
MTIC 7.4
3-hydroxyisovaleric acid 7.3
2-methylcitric acid 7.3
Fostriecin 7.2
Trimethadione 7.2
Sphinganine 7.2
N,N'-diisopropylcarbodiimide 7.2
Acivicin 7.2
Cresol 7.2
4-OH-A 7.1
Sulfobromophthalein 7.0
propionyl-carnitine 7.0
ICRF 159 7.0
A-14 7.0
ICRF 159 6.9
ICRF 159 6.9
Bromodichloromethane 6.8
Pralidoxime 6.8
CNQ 6.6
Eflornithine 6.6
Dimenhydrinate 6.6
IMPY 6.6
Pulegone 6.6
Sodium cyanide 6.6
3-methylcrotonyl-CoA 6.5
T-2 mycotoxin 6.4
Swainsonine 6.4
Phentermine 6.4
Diethyl maleate 6.4
Fusaric acid 6.3
Benzoylecgonine 6.3
Fusaric acid 6.3
Fusaric acid 6.3
Zinc chloride 6.3
Nedaplatin 6.3
Cefdinir 6.3
Clobazam 6.2
Castanospermine 6.2
Carbimazole 6.2
Mesna 6.1
propionyl-coenzyme A 6.0
Methylcobalamin 6.0
Ziprasidone 6.0
Mirtazapine 6.0
sebacic acid 6.0
2-ethylhexanoic acid 6.0
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