Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It was the purpose of this work to verify the hypothesis of Poskanzer and Schwab according to which nearly all cases of parkinsonism are consequences of clinical and subclinical lethargic encephalitis in the years 1917-1926. The investigated material included 495 patients with parkinsonism treated at the neurological hospital departments in Warsaw in the years 1967-1976 and 263 patients living in the City of Warsaw and treated as outpatients or inpatients in the years 1972-1976. The control group comprised patients with amyotrophic lateral sclerosis treated in the Warsaw hospitals in the years 1967-1976. The correlation between the mean age at the time of disease onset and the calendar year of disease onset was studied in different groups of patients. The indices of disease prevalence, first visits and mortality were calculated in the group of patients living in the City of Warsaw. Low values of correlation indices and persistence of approximately unchanged indices of first visits and mortality in the years 1972-1976 failed to confirm the hypothesis of Poskanzer and Schwab.
Neurol Neurochir Pol
PMID:[Etiology of parkinsonism. A verification of Poskanzer's and Schwab's hypothesis]. 51 36

A 41-year-old man is described in whom after a febrile disease with disturbances of sleep rhytm and exessive somnolence, extrapyramidal signs appeared increasing progressively in intensity, with a hypertonic-hypokinetic syndrome with evidence of right-sided spastic hemiparesis and hypaesthesia. After treatment with Viregyt and low doses of L-Dopa a striking improvement was obtained. Parkinsonism following lethargic encephalitis was diagnosed.
Neurol Neurochir Pol
PMID:[Parkinsonism following lethargic encephalitis]. 59 10

Involvement of the conduction system of the heart in Wegener's granulomatosis (WG) is rare. We present a 53-year-old man with WG pulmonary, renal and left eyeball involvement and with a high initial level of cANCA (1: 640). He was treated with steroids, cyclophosphamide and cyclosporine. After 14 months he presented with lethargy and presyncope due to a complete atrio-ventricular block with an escape rhythm of 35 beats/min. The temporary pacing electrode was inserted, followed by permanent DDDR pacemaker implantation on the third day as the block persisted despite WG treatment intensification. Clinical picture showed the disease in a progressive state.
Kardiol Pol 2006 Jun
PMID:[Complete heart block due to Wegener's granulomatosis: a case report and literature review]. 1681 May 83

Hyperparathyroidism during pregnancy is diagnosed in 0.5-1.4% women and poses a serious challenge. Symptoms of primary hyperparathyroidism (PHP), namely fatigue, lethargy and proximal muscle weakness, are unspecific and could be mistaken as complaints naturally present during pregnancy. Thus, diagnosis is usually delayed. Moreover, the complications of PHP are very common. They occur in 67% of mothers and even in up to 80% of progeny. Appropriate management is a matter of debate. According to clinical symptoms, biochemical evaluation and trimester of pregnancy an operation or conservative management should be introduced. The recognition and understanding of the illness is therefore vital. Due to the lack of unequivocal guidelines concerning pregnancy and PHP, in this review we will analyze recent findings to facilitate proper proceedings.
Ginekol Pol 2017
PMID:Primary hyperparathyroidism in pregnancy - a review of literature. 2858 May 74