Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

2,4-Dichlorophenoxyacetic acid (2,4-D) was administered once orally to adult female mongrel dogs at 0, 25, 50, 75, 100 or 125 mg/kg of body weight (n = 4 per group). Clinical neurological examinations, electromyography (EMG) and motor nerve conduction velocity measurements were carried out before exposure, and on days 1, 3, 7, 14, 21 and 28 post-exposure. On day 7, two dogs per group were killed. Samples of the medial and lateral plantar nerves were removed for teased fiber and semi-thin section analysis; samples of appendicular muscles were removed for histology and histochemistry. Necropsy included histopathological examination of the brain and spinal cord at multiple levels. Remaining dogs were killed on day 28 and their tissues were processed similarly. Transient generalized myotonic discharges were found in skeletal muscles of dogs receiving 50 mg/kg or more of 2,4-D. A few dogs in the higher dosage groups also had mild muscle stiffness, myotonic dimpling and/or lethargy, lasting up to 3 days post-exposure. Other parameters remained within normal limits.
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PMID:Neuromuscular effects of acute 2,4-dichlorophenoxyacetic acid (2,4-D) exposure in dogs. 358 4

The acute toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D) was studied in cattle. Steers were orally treated with 100, 300 or 600 mg 2,4-D/kg. Behavioral alterations, heart and respiratory functions, rectal temperature and ruminal movements were observed at 2, 4, 8, 12, 24, 48, 72 and 96 h after treatment. At these moments, blood and urine samples were collected and serum 2,4-D levels were determined. Results show that animals' vital function and hematocrit were not modified by the herbicide. Other signs were doses and time-dependent and included motor alterations (weakness, lethargy, decreased general activity) and decreased ruminal movements and proteinuria. The herbicide was rapidly excreted and the intoxication signs were completely reserved. 2,4-D is an herbicide of small toxicological consequences for cattle kept under in natural grazing systems.
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PMID:Acute 2,4-dichlorophenoxyacetic acid intoxication in cattle. 783 69