Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 42-year-old man was admitted because of episodic attack of general malaise. He was lethargic and had a severe lactic acidosis and hypoglycemia. Blood chemistry and endocrinological data were normal. Glucose administration led to an improvement in the hypoglycemia but not the lactic acidosis. At autopsy, there was a massive infiltration of leukemic cells in both kidneys and in liver. Phosphoenolpyruvate carboxykinase, pyruvate carboxylase and glucose-6-phosphatase activities in patient's liver were much the same as in the control liver, but fructose-1, 6-diphosphatase activity was slightly reduced. Since circulatory failure was absent, type B lactic acidosis has to be considered. Since hypoglycemia was associated with acidosis, the severe lactic acidosis in our patient may have been due to an overproduction of lactic acid as well as to an impaired hepatic gluconeogenesis in the presence of leukemic cells.
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PMID:Lactic acidosis and hypoglycemia associated with acute leukemia. 386 4

We represent a case of cystic dilatation of the fourth ventricle resulted from obstruction of the foramina of Luschka and Magendie and of the aqueduct of Sylvius which developed after a surgery of AVM. A 42-year-old woman was admitted to our clinic for the operation of AVM located at the trigone of lateral ventricle and the lateral wall of midbrain. VPS had been performed previously because of acute hydrocephalus resulted from several attacks of ventricular hemorrhage. Total removal of the AVM was performed. The patient was stuporous after the surgery, and CT scan showed marked distension of the fourth ventricle with shifted third ventricle and slightly dilated supra-tentorial ventricular system. Although a revision of the abdominal side of VPs performed and the lateral and the third ventricles were shunted effectively, the fourth ventricle continued to show remarkable distension. Since it was considered that the occlusion of the foramina of Luschka and magendie due to previous episodes of ventricular hemorrhage and the blockage of the aqueduct of Sylvius 'trapped' the fourth ventricle, suboccipital craniotomy and re-opening of the foramen of Magendie was performed. The arachnoid membrane around the cisterna magna was strongly adhered to the dura mater. When incision was made on the arachnoid membrane between the cerebellar tonsils, slightly turbid and xanthochromic CSF spurted out and some old clots were also aspirated from the opened fourth ventricle. The size of the fourth ventricle returned normal on CT scan ten days after the operation, and the patient recovered progressively afterwards.
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PMID:[A case of trapped fourth ventricle which developed after a surgery of AVM (author's transl)]. 727 34

The authors report a case of a huge colloid cyst of the septum pellucidum with acute worsening. A 42-year-old man was admitted for unexplained lethargy. A brain CT scan disclosed a huge intra-ventricular lesion. He experienced a sudden deterioration with coma, and was managed with bilateral ventricular external shunting. Total removal was performed a few days later using a right frontal trans-ventricular approach. The discussion focuses on colloid cyst potential to mimic other intracranial lesions, rendering accurate diagnosis difficult and leading to possibly inappropriate management in similar cases.
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PMID:Huge colloid cyst: case report and review of unusual forms. 1505 35

An elevated total or low-density lipoprotein (LDL) cholesterol levels or low levels of high-density lipoprotein (HDL) cholesterol is defined as dyslipidemia which is an important risk factor for coronary artery diseases (CADs) and strokes. It is estimated that abnormal cholesterol levels in the blood lead to cause about 18% of cardio vascular diseases (CVDs) and 56% of the ischemic heart diseases at global level. In comparison with others, South Asians have the highest incidence rate of CADs. Acharya Charaka has mentioned Rukshana Upakrama (a type of management which induces dryness) as one amongst the Shad-Upakrama (six principles of management) and can be considered as the best for the reduction of increased Kapha Dosha, Meda Dhatu (adipose tissue) and their related morbid factors. A 42-year-old female patient visited the OPD of the department of Basic Principles, IPGT and RA, Jamnagar, Gujarat, with the complaints of weight gain, heaviness in the body and lethargy. After investigation, she was diagnosed as a case of dyslipidemia due to abnormality in cholesterol levels. She was treated with Takra-Siddha Yavagu (gruel prepared with buttermilk) and Udvartana (dry powder massage) for 30 days. After completion of treatment, hematological investigations revealed that her serum cholesterol level was decreased to 147 mg/dl from 223 mg/dl and serum LDL was reduced to 91 mg/dl from 153 mg/dl. Her weight also reduced to 82 kgs from 88 kgs. Hence, it can be concluded that Rukshana Upakrama in the form of Takra-Siddha Yavagu and Udvartana is effective in the management of dyslipidemia for normalization of lipid in the blood as it possesses Shoshana (absorption) and Kapha-Medohara (alleviation of vitiated Kapha and Meda) properties.
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PMID:Hypolipidemic effect of Rukshana Upakrama in the management of dyslipidemia - A case study. 3078 60