Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nesidioblastosis associated with progressive weight loss and hyperglycemia was diagnosed in two mid-adult, wild-caught, male squirrel monkeys (Saimiri sciureus). Hyperglycemia, glucosuria, and abnormal glucose tolerance test results were found when the monkeys were presented for clinical evaluation for chronic weight loss, episodic dehydration, hypothermia, and lethargy. Immunohistochemical studies of the pancreatic tissue demonstrated that the proliferating endocrine cells stained predominantly glucagon-positive in the most severely affected monkey.
J Med Primatol 1996 Oct
PMID:Nesidioblastosis associated with hyperglycemia in two squirrel monkeys (Saimiri sciureus). 902 1

Laparoscopic surgery was performed on a 16 year-old female rhesus monkey presenting with chronic lethargy and inappetence. The procedure revealed a "napkin-ring" stricture located in the ascending large colon. Histologic evaluation of the colonic lesion exhibited large numbers of irregular acini lined by a single layer of well-differentiated neoplastic epithelial cells. Based on the gross and histopathologic findings a diagnosis of adenocarcinoma of the proximal colon was made.
J Med Primatol 1997 Oct
PMID:Stenosing colonic adenocarcinoma in a female rhesus monkey. 943 60

An anaplastic large cell lymphoma with disseminated abdominal metastases was diagnosed in a 35-year-old male chimpanzee. Clinically, the animal displayed lethargy, weight loss, ascites, and abdominal distention. Imaging studies showed several large abdominal masses. At necropsy, variably sized masses of neoplastic mesenteric lymph nodes that encompassed several intestinal loops were present throughout the abdomen. The largest mass measured 9 x 5 cm and had cauliflower-like protrusions into the jejunal lumen. The entire abdominal cavity was covered by a sheet of neoplastic tissue. Histopathologically, the tumor consisted of solid sheets of proliferating lymphoid cells forming a cohesive growth that filled the lymph node sinuses. The tumor had invaded the intestinal wall. Anaplastic large cell lymphoma was diagnosed from immunohistochemistry findings on the basis of positive reaction to the CD3 and CD30 markers and negative reaction to the CD20 marker. Serologic analysis revealed positive titers for Epstein-Barr, cytomegalo-, and varicella-zoster viruses. Both serologic and virologic studies showed no evidence of detectable retroviral infection. This type of tumor has not been reported before in the chimpanzee.
J Med Primatol 1997 Oct
PMID:Spontaneous anaplastic large cell lymphoma in a chimpanzee: a clinicopathological and immunohistochemical study. 943 65

A 17-year-old, 1-kg, colony-housed, male squirrel monkey (Samiri sciureus) developed clinical signs of congestive heart failure. The monkey presented with lethargy, increased heart and respiratory rates, and mild abdominal distention. The clinical history, laboratory analysis, and radiographic findings were consistent with heart failure due to dilative cardiomyopathy. Gross and microscopic examination of the heart confirmed a dilative cardiomyopathy. This is the first report describing congestive heart failure caused by dilative cardiomyopathy in a squirrel monkey. Spontaneous dilative cardiomyopathy may be infrequently observed in the squirrel monkeys because they are not routinely housed in the research environment during their advancing years.
J Med Primatol 2000 Feb
PMID:Dilative cardiomyopathy leading to congestive heart failure in a male squirrel monkey (Saimiri sciureus). 1151 76

Over the course of 4 weeks, two female aged bonnet macaque (Macaca radiata) group-housed females died after the dominant male was removed from the group and the newly dominant male persistently chased, caught and bred all females in the pen. The two aged affected females were observed exhibiting lethargy, dyspnea, with widespread necroulcerative lesions in and around the mouth, muzzle and bridge of their noses. Extensive ulcerative glossitis, necrotic bronchopneumonia with intra-nuclear inclusions and the absence of other evidence is highly suggestive that death was caused by an alphaherpes virus commonly known as herpes B virus. Herpes B virus is a potentially zoonotic disease periodically shed by macaques, which is structurally related to herpes simplex viruses I and II of humans. The emergence of fatal B virus to primates in this pen may have been associated with the combination of age and stress in the affected individuals.
J Med Primatol 2008 Feb
PMID:Lethargy, ulcers, bronchopneumonia and death in two aged female bonnet macaques presumed to be caused by Cercopithicine herpes virus I. 1826 31

A chimpanzee (Pan troglodytes) was presented with lethargic behaviour. Echocardiography and abnormal cardiac and inflammatory biomarkers revealed a myocarditis. The animal fully recovered after prolonged treatment with losartan and carvedilol. This is the first report of the diagnosis and successful treatment of myocarditis in this species.
J Med Primatol 2017 10
PMID:Clinical signs, diagnostics and successful treatment of a myocarditis in an adult chimpanzee (Pan troglodytes). 2852 58

Between 2011 and 2016, approximately 50% of siamangs in the Way Canguk Research Area disappeared, including members of 7 of 12 habituated groups. Demographic data from 1998 to 2015 confirm that the population decline in the habituated groups reflects a larger trend in the local population. There was no evidence of hunting of primates in the area, and ecological data do not suggest substantial changes in food availability or predation pressure during this period. From 2011 to 2014, we monitored the habituated groups only intermittently, and most deaths or disappearances were not observed. However, in 2014-2016, we monitored some groups more intensively, and observed 2 individuals with symptoms including whitened skin on the face, hands, and abdomen, hair loss, swelling of the face, frequent scratching, and lethargy. One affected individual disappeared days after this observation, while the other survived. The spatiotemporal pattern of disappearances in the habituated groups was consistent with that expected if the deaths resulted from disease transmission among neighbouring groups. Thus, the available evidence, while preliminary, suggests that a local disease epizootic may have been a factor driving the population decline. We recommend that researchers establish monitoring protocols to better understand primate disease epidemiology and to guide conservation management.
Folia Primatol (Basel) 2017
PMID:Abrupt Decline in a Protected Population of Siamangs (Symphalangus syndactylus) in Southern Sumatra. 2884 77

A brown howler monkey (Alouatta guariba clamitans) was presented with lethargy, hyporexia, cough and heart murmur. The complementary tests and necropsy revealed pleuropneumonia, bacterial endocarditis and interventricular septal defect. To the best of our knowledge, this is the first report of increased cardiac troponin I levels in this species.
J Med Primatol 2019 Apr
PMID:Bacterial endocarditis and increased cardiac troponin I levels in a brown howler monkey (Alouatta guariba clamitans) with an interventricular septal defect. 3041 59