Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to establish whether somnolence syndrome existed in adults by exploring their experiences after receiving cranial radiotherapy. Somnolence syndrome is described as excessive sleep, drowsiness, lethargy and anorexia and was found to occur in these patients. A description of the phenomenon was drawn from triangulation of the data. For 6 weeks following radiotherapy, the participants completed a diary consisting of two elements, a quantitative visual analogue scale and an open diary. This was followed by a qualitative semi-structured interview. Patients experienced sleepiness which they described as 'exhausted doing nothing' and that any activity was a 'struggle'. Some individuals described sensory changes, deafness and an increase in leg and arm weakness. These experiences presented a series of unexpected changes in their health which resulted in fear of treatment failure and disease recurrence. The study suggests that more information should be provided for patients on the side-effects that occur after radiotherapy has finished. Somnolence syndrome presented for the participants an experience which is not adequately described in previous literature. The nurse has an important role in providing information to prepare patients for their experience and more knowledge about this phenomenon is required for these patients to be informed adequately.
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PMID:Patients' experiences following cranial radiotherapy: a study of the somnolence syndrome. 177 82

Carotid body tumour (CBT) surgery has a risk of stroke. A 57-year-old lady presented with lethargy and generalised limb pain secondary to a right parathyroid adenoma. CT scan demonstrated as an incidental finding of a left CBT. Intraoperatively the CBT was infiltrating the vessel wall. The carotid bifurcation was resected and reconstructed using a reversed saphenous vein graft. Postoperatively the patient developed right arm weakness. A CT scan showed a left hemispheric watershed infarct. On discharge (day 8 postoperatively) she had no functional deficit. Reconstruction of the internal carotid artery in patients with CBT is associated with an increased risk of stroke. This index case and literature research highlight the knowns and unknowns on stroke associated with CBT resection.
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PMID:The known unknowns of perioperative stroke during carotid body tumour resection. 2350 77