Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Involvement of the conduction system of the heart in Wegener's granulomatosis (WG) is rare. We present a 53-year-old man with WG pulmonary, renal and left eyeball involvement and with a high initial level of cANCA (1: 640). He was treated with steroids, cyclophosphamide and cyclosporine. After 14 months he presented with lethargy and presyncope due to a complete atrio-ventricular block with an escape rhythm of 35 beats/min. The temporary pacing electrode was inserted, followed by permanent DDDR pacemaker implantation on the third day as the block persisted despite WG treatment intensification. Clinical picture showed the disease in a progressive state.
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PMID:[Complete heart block due to Wegener's granulomatosis: a case report and literature review]. 1681 May 83

A case report of an army soldier presenting to the emergency department with acute metabolic derangement resulting in encephalopathy, cerebral edema, and death is presented. The patient had no medical diagnoses before entering military service and was triaged in the emergency department with the common complaint of presyncope. However, as encephalopathy worsened, the patient experienced altered mental status, lethargy, emesis, and seizure. This patient ultimately died because of rapid decompensation. Maple syrup urine disease pathophysiology and treatment recommendations are reviewed.
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PMID:Unusual Case of Acute Decompensated Maple Syrup Urine Disease in the Emergency Department. 3321 Jul 10