Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Demographic characteristics of specific somatic complaints were studied systematically in 60 consecutive patients whose main complaints were bodily symptoms without organic pathology, to determine if the social and demographic factors in any way influenced the nature or localisation of specific common somatic complaints. The Scale for Assessment of Somatic Symptoms was used to systematically acquire details of individual complaints. The commonest somatic complaints identified were weakness of body or mind (72%), headache (67%), fatiguability (37%) and burning sensations (35%). Subjects with less education reported weakness of body and mind, and multiple sites of pain more often, but lethargy and fatiguability less often than those with higher education. Rural subjects reported burning sensations and pain in their extremities more frequently. A sensation of 'gas' was more often reported by younger subjects, and pain in the extremities by male subjects. The factors which determine the choice of somatic complaints remain elusive and the exact reasons for these demographic relationships are unclear at present.
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PMID:Do social and demographic factors influence the nature and localisation of somatic complaints? 819 Aug 44

To determine the clinical presentation and manifestations of Paget's disease of the bone in patients older than 60 years, we reviewed the cases of 56 patients attending a bone clinic. Pain was the presenting symptom in 34 cases. It was attributed to the disease process in 21 cases, to osteoarthritis in 11, to trigeminal neuralgia in 1, and to osteosarcoma in 1. Other clinical manifestations included deformities (15 cases), diminished mobility and unsteady gait (9), hearing impairment (7), lethargy (4), diminished vision (3), cognitive deficit (3), sense of warmth in limbs (2), ill-fitting dentures (1), and fracture (1). We concluded that in patients older than 60 years, Paget's disease of the bone may present itself in a variety of ways, some of which may be mistakenly attributed to the "aging process" or some other disease. Furthermore, in this age group, osteoarthritis is responsible for the pain experienced by about one third of symptomatic patients.
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PMID:Clinical presentation of Paget's disease of the bone in older patients. 821 23

A study of literature concerning Lyme borreliosis related to animals was done. In the research work the epidemiology, pathogenesis, diagnosis and treatment of horses, cattle and dogs affected with Lyme borreliosis have been discussed. The clinical signs of Lyme borreliosis in horses are: chronic weight loss, sporadic lameness, laminitis, low grade fever, swollen joints, muscle tenderness and anterior uvetitis. In addition to these clinical sings, neurological sings such as depression, behavioral changes, dysphagia and encephalitis can be seen in chronic cases. Cattle affected with acute Lyme borreliosis often show fever, stiffness, swollen joints and decreased milk production. Chronic weight loss, laminitis and abortion are also a possible outcome of borreliosis in cattle. An early infection of Lyme borreliosis in dogs may give evidence of inapetenca, lethargy, lyphadenopathy, and an acute onset of stiffness or pain while a recurrent intermittent nonerosive arthritis is a more advanced manifestation of canine Lyme borreliosis. Glomerulonephritis and tubular damage secondary to Borrelia burgdorferi infection have been reported to occur in normally infected dogs. In an endemic area atrioventricular heart block has also been reported. The underlying pathogenesis of Lyme disease is still unknown. The diagnosis of clinical Lyme borreliosis is difficult and it depends on a successful recognition of clinical signs, a history of possible exposures to the infection and on serologic testings. The therapy of Lyme borreliosis in animals is based upon the principal therapy of this disease in human medicine.
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PMID:[The importance of Lyme borreliosis in veterinary medicine]. 826 22

The safety profile of a new controlled-titer feline panleukopenia-rhinotracheitis-calicivirus-Chlamydia psittaci vaccine was compared to that of a currently-marketed vaccine. Of particular interest were delayed reactions (previously unreported in the literature in felines) occurring 7 to 21 days after vaccination, and the effect of concurrent vaccinations and cat age on the delayed reaction rate. Nineteen hundred twenty-four doses of the new vaccine and 364 doses of the comparison vaccine were administered in 42 participating veterinary practices. The postvaccination evaluation period was 21 days. Reactions (anaphylaxis, short- and long-term lethargy, inappetence, pain, upper respiratory inflammation, delayed fever, anorexia, and miscellaneous events) were reported in 3.33% of cats receiving the controlled-titer vaccine and in 3.02% of cats receiving the comparison vaccine. The difference was not statistically significant (P = 0.45). Reaction rate of the controlled-titer vaccine and that of the vaccine currently accepted by veterinarians appear to be equivalent.
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PMID:Reaction rate in cats vaccinated with a new controlled-titer feline panleukopenia-rhinotracheitis-calicivirus-Chlamydia psittaci vaccine. 830 54

Lower limb amputations for peripheral arterial disease are performed predominantly on an elderly population with poor social support and concomitant medical problems. The effect of amputations on the quality of life of this population has not been properly assessed. The quality of life of 149 amputees from one hospital was evaluated using the Nottingham Health Profile and compared to that of a control group matched for age and sex. One hundred and thirty (87%) amputees and 115 (77%) controls responded to the questionnaire. Amputees reported significantly more problems with mobility, social isolation, lethargy, pain, sleep and emotional disturbance than controls (p < 0.001). However, mobility was the only significant independent factor after matched logistic regression analysis (p < 0.001). The differences in social isolation and emotional distress lost their significance after adjustment for mobility. The overall quality of life following lower limb amputation for peripheral arterial disease is poor, but much of this is secondary to restricted mobility. Rehabilitation following amputation should therefore focus on attempts to improve mobility.
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PMID:Quality of life following lower limb amputation for peripheral arterial disease. 835 4

Although a variety of pharmacological agents have been used to treat patients with chronic fatigue syndrome none has been shown to effect a complete resolution of symptoms. Data obtained from a retrospective study and from an objective assessment of the aerobic work capacity of patients with this disorder suggest that the underlying pathophysiological abnormality is a disorder of sleep regulation. This results not only in profound fatigue and lethargy but also reduced sensory threshold for pain, disordered temperature regulation, cardiovascular abnormalities, disturbed higher cerebral function and mental depression. Drugs which modulate sleep, such as tricyclic antidepressants, have a limited effect in improving the symptoms that CFS patients experience. We suggest that other agents which affect central nervous system neurotransmitters, particularly serotonin, may have potential in the management of this condition and need to be evaluated in large controlled clinical trials.
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PMID:Pharmacological approaches to the therapy of chronic fatigue syndrome. 849 Nov 3

The research presented here aimed to obtain population norms on pertinent domains of quality of life and health related quality of life, and the relative importance of these domains to people. The OPCS Omnibus Survey was used as the vehicle for the study. This is a monthly survey of a random sample of 2000 adult members of the population in Great Britain, based on a random sample of households. The data was collected for a one month period. The response rate to the survey was 77%. In response to a generic question about the five (priority ordered) most important things in their lives (good or bad), respondents were most likely to freely mention as the first most important thing in their lives relationships with family or relatives, followed by their own health, the health of another (close) person and finances/standard of living/housing. When responses relating to respondents' priority ranked areas 1-5 were combined, the most frequently mentioned area of life was finances/standard of living/housing, followed by relationships with family and friends, own health, the health of close others and social life/leisure activities. Thus, different distributions were obtained depending on whether priority ordering or frequency with which item was mentioned was analysed. Of those who reported a longstanding illness, the conditions which were most likely to be reported as affecting their lives were respiratory conditions, joint disorders and heart and circulatory diseases. The most commonly freely mentioned first most important effects of the longstanding illness on their lives were (in order of frequency) ability to get out and about/stand/walk/go out shopping, being able to work/find a job and effects on social life/leisure activities (based on office coding from verbatim responses recorded on the questionnaire). When the responses relating to respondents' priority ranks 1-5 were combined, the most frequently mentioned area of life affected was ability to get out and about/stand/walk/go out shopping, followed by social life/leisure activities, and availability of work/ability to work. Again, differences in distributions were obtained depending on the method of analysis. Further investigations also revealed differences according to the method of questioning and coding (respondent vs office). When respondents selected their own codes from a showcard in relation to health effects, there were some discrepancies with their (office coded) verbatim replies (which were recorded by the interviewer before they saw the showcard, for later office coding). The showcard had the effect of prompting them, and the then most commonly mentioned first most important effects of the longstanding illness on their lives were (in order of frequency) pain, tiredness/lack of energy/lethargy, social life/leisure activities, and availability of work/ability to work. This discrepancy illustrates the biasing influence of using showcards, in comparison with the open coding of actual verbatim responses back in the office (on the assumption that the latter are more valid-unprompted-responses). Analysis of the domains included in the most popularly used health status scales, which are used to measure health related quality of life, revealed that several items ranked as important by the public were missing.
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PMID:What things are important in people's lives? A survey of the public's judgements to inform scales of health related quality of life. 856 Mar 13

Rhino-orbital-cerebral mucormycosis is a disease that is frequently fatal. A 39-year-old man with diabetic ketoacidosis was referred to the authors' ophthalmic service with fever, orbital apex syndrome in the right eye, lethargy, and a black eschar in the palate. He was treated with systemic and local (intraconal) amphotericin B and his ketoacidosis was controlled; exenteration was not performed. Biopsy of the palate proved mucormycosis. Eighteen months later the patient was still alive and had a blind, anatomically preserved right eye with ptosis and intact extraocular muscle function without proptosis or pain. The authors propose this alternative means of treatment to achieve higher doses of the drug at the site of infection and better cosmetic and psychological results.
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PMID:Intraconal amphotericin B for the treatment of rhino-orbital mucormycosis. 885 37

A 10-month-old male maremma shepherd dog was presented with chronic diarrhoea, moderate polyuria/polydipsia, lethargy, dysorexia and stiffness. Pain was elicited in the distal parts of all four limbs. Radiographs of the limbs showed increased endomedullary radiopacity and lysis, with thick periosteal proliferations at the metadiaphyseal areas of each radius-ulna and tibia and of the distal metacarpus on one side. Polyclonal hypergammaglobulinaemia was documented and a similar electrophoretic protein pattern was also found in the synovial fluid. Leishmania amastigotes were found in the macrophages in a bone marrow aspirate performed at the level of a distal radius and in a synovial fluid sample obtained from a carpal joint. An indirect immunofluorescence test confirmed the infection. Treatment with N-methyl-glucamine antimoniate was successful and the osteoarticular changes progressively disappeared.
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PMID:Osteomyelitis and arthrosynovitis associated with Leishmania donovani infection in a dog. 912 Nov 32

Adoptive immunotherapy (AI) with interleukin-2 (IL-2) and lymphokine-activated killer cells (LAK) is an antineoplastic modality in which immune-activated cells are administered to a host with advanced cancer in an attempt to mediate tumor regression. Levamisole (LEV), an immune stimulant, has been suggested to have therapeutic effectiveness in a variety of cancers. After a phase I trial of recombinant IL-2 plus LEV, a phase II trial of this combination was conducted in patients with advanced malignant melanoma. Nineteen patients were entered in the trial. They received IL-2 at 3 x 10(6) U/m2 subcutaneously daily x 5 plus LEV 50 mg/ m2 orally three times daily (p.o. t.i.d.) x 5. Patients were reevaluated at four-week intervals. None of the patients achieved a partial or complete regression (PR, CR). The median time to treatment failure (refusal, progression, or off study due to toxicity) was 56 days. Grade IV toxicities included vomiting (3 patients), lethargy (1 patient), and musculoskellar pain (1 patient). This regimen is not recommended for further testing in patients with advanced malignant melanoma.
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PMID:Phase II study of combined levamisole with recombinant interleukin-2 in patients with advanced malignant melanoma. 934 34


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