Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A relatively high percentage of hypnotic-sedative drug-overdosed (HSDO) patients suffer post-extubation upper airway obstruction. Since early detection and treatment of these lesions is desirable, we studied 20 recently extubated (within 24 hours) as well as 11 non-intubated HSDO patients employing flow-volume loops and spirometry. Abnormalities in tests for upper airway obstruction were common in both groups but only in the four post-extubation patients with clinically suspected upper airway obstruction was an inspiratory plateau by flow volume loops found. In addition, three of these four patients had mid-VC ratios greater than 1.25. We conclude that the Inspiratory flow volume loop and the mid-VC ratio may help in detecting post-extubation upper airway obstruction in lethargic, HSDO patients.
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PMID:Post-extubation pulmonary function tests in detection of upper airway obstruction in drug-overdosed patients. 60 56

The study of insulin secretion by the technic of perifusion of pieces of pancreas at increasing temperature allowed us to point out that the pancreas of the lethargic hedgehog is more sensitive to temperature than that of the active hedgehog or that of the Rat.
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PMID:[In vitro studies of the effect of temperature on insulin secretion in the rat, the active and the lethargic hedgehog (author's transl)]. 61 70

A female infant with neonatal hypotonia and lethargy was found to have nonketotic hyperglycinemia. She died at the age of 5 days. Autopsy revealed slightly retarded myelination and severe spongy change in the well-myelinated areas of the brain. Analysis of this and the other 26 reported cases suggests that patients with nonketotic hyperglycinemia develop severe mental retardation, not seen in ketotic hyperglycinemia. Elevated glycine levels in the brain and cerebrospinal fluid appear to differentiate these two forms of hyperglycinemia better than the presence of ketosis or leukopenia, and high glycine levels apparently occur in the same areas as the spongy change. While both forms show defective glycine cleavage in the liver, defective glycine cleavage in the brain has been reported only in nonketotic hyperglycinemia.
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PMID:Nonketotic hyperglycinemia: report of a case and review of the clinical, chemical, and pathological changes. 61 56

Clonazepam, a new anticonvulsant, appears to be useful for childhood minor motor seizures and for petit mal refractory to Ethosuximide and Trimethadione. It appears less effective in infantile spasms though may be beneficial when there is no response to steroids. It is variably effective in partial complex and focal epilepsy and may exacerbate tonic seizures. A transient disadvantage is the high incidence of side effects, especially lethargy and ataxia, though these may be transitory. Aggressivity and hyperkinesis may necessitate medication withdrawal. Some children who initially respond to therapy and then relapse may respond again to a higher dosage.
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PMID:The utility of clonazepam in epilepsy of various types. Observations with 22 childhood cases. 61 1

A simple implanted device was used to occlude acutely the left middle cerebral artery (MCA) of 16 conscious cats. Eight received no treatment and 8 were given intravenous mannitol (1.2 gm/kg) at the time of occlusion. The initial neurological findings in both groups were similar, that is, agitation, forced circling, and right hemiparesis. The treated cats remained alert but the untreated cats became lethargic and drowsy. Perfusion with a mixture of colloidal carbon and buffered paraformaldehyde was carried out from 30 minutes to 6 hours following MCA occlusion. Results of morphological examination of brains from the treated and untreated groups suggested that mannitol had a protective effect upon cerebral tissue during the primary phase of acute focal ischemia. Light microscopic analysis of neuronal alterations demonstrated considerable preservation of neurons in brains of treated cats. Beneficial effect of mannitol was attributed partly to prevention of capillary narrowing and suppression of ischemic cerebral edema.
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PMID:Modification of acute focal ischemia by treatment with mannitol. 62 43

Nineteen children with the hemolytic-uremic syndrome were treated in our hospital from 1968 to 1976. Seven were over 5 years of age. The disease occurred most often in the spring of the year. Lethargy was a prominent symptom in all patients, and seizures occurred in seven. Transfusion and dialysis were the most important treatment modalities. Heparin was used in four children and did not appear to affect the course of disease although three recovered. Thirteen of 15 children who did not receive heparin recovered. Irreversible renal failure occurred in three children, all of whom were in the older age group. Serious sequelae were rare in those who survived.
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PMID:The hemolytic-uremic syndrome: experience at a center in the Midwest. 62 66

An instance of massive hemorrhage following transtracheal aspiration with successful resuscitation is reported. Indications for the procedure are pneumonia with poor ability to produce sputum, fever, or pulmonary infiltrate in a stuporous patient, and facial injuries which would complicate nasotracheal suction. The cricothyroid membrane is recommended as the site of entry. If airway hemorrhage does occur, immediate maintenance of the airway and tamponade of the bleeding can aid in successful resuscitation of the patient.
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PMID:Massive airway hemorrhage after transtracheal aspiration. 62 56

The use of jejunum in conduit urinary diversion may lead to electrolyte disturbances, characterized by hyponatremia, hypochloremia, hyperkalemia, acidosis, and azotemia, and a clinical picture of nausea, vomiting, dehydration, anorexia, and lethargy. Four out of six patients deviated with a jejunal loop developed this syndrome, the cause of which is discussed. It is concluded that the use of jejunum in urinary diversion should be avoided.
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PMID:Electrolyte distrubances after jejunal conduit urinary diversion. 63 83

Among the psychosyndromes least well known to be associated with an endocrinopathy is apathetic hyperthyroidism. This condition is characterized by apathy, lethargy, severe "senile depression" and often a high output cardiac failure occurring as the presenting problem.1,2,9 The depressive component of the clinical picture may occur without cardiac complications. Such depressions in the elderly, while refractory to treatment with antidepressant drugs, often respond dramatically to the correction of the underlying endocrine dysfunction.4 It is therefore important to consider "thyroid melancholia" in the differential diagnosis of such cases. Given this high index of suspicion, the diagnosis can be fairly easily made.
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PMID:Apathetic hyperthroidism. 64 Oct 24

A 36-year-old man had pain in both knees and an elevated uric acid concentration; his liver function was normal. Allopurinol therapy was started, 100 mg twice daily. After one month fever, lethargy, and severe polyarthralgia developed. On admission to our hospital liver function was abnormal, and a liver biopsy specimen showed granulomas with cholangitis and pericholangitis. He also had lymphopenia with a reduced number of T cells and granulomas in the bone marrow. One month after discontinuation of allopurinol therapy the patient was clinically well with normal liver function and a normal lymphocyte count. A repeated liver biopsy specimen showed normal liver tissue with no granulomas. The onset of the symptoms and findings shortly after the initiation of allopurinol therapy, and their disappearance after the discontinuation of therapy suggest a drug-induced hypersensitivity.
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PMID:Allopurinol-induced granulomatous hepatitis with cholangitis and a sarcoid-like reaction. 64 70


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