Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neurinomas of trigeminal nerve are rare intracranial tumors and spontaneous intratumoral hemorrhage occurred exceedingly rarely in them. Herein, we report one case of trigeminal neurinoma presenting spontaneous intratumoral hemorrhage. Presenting symptoms were headache, lethargy and vomiting of sudden onset. Unenhanced computed tomography scans showed a high density mass in the left cerebellopontine angle cistern. On magnetic resonance images, they revealed hyperintensity on both T1- and T2-weighted images. A left retromastoid suboccipital craniectomy was performed and nearly total tumor removal was achieved. Histologically, increased vascularity, dilated vessels and hemosiderin were observed in the specimen. Tumor size, hypervascularity and vascular change are important factors for hemorrhage.
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PMID:Trigeminal neurinoma presenting as intratumoral hemorrhage--case report. 984 46

Congenital glioblastoma multiforme is a rare primary brain tumor that has a unique biology distinct from pediatric and adult variants. In this report, we present a case of congenital glioblastoma with complicated management course. A literature review of previously reported cases is included to illustrate the epidemiology and natural history of this disease. A 9-month-old male infant developed acute lethargy, hemiparesis and unilaterally dilated pupil. Imaging studies revealed a large hemispheric tumor, resulting in significant midline shift suggestive of impending herniation. Emergent tumor cystic fluid drainage was performed at initial presentation. A frontotemporoparietal craniotomy was performed on the following day to attempt a gross total resection. Adjuvant chemotherapy consisting of oral temozolomide was administered. The patient eventually succumbed 4 months later due to aggressive tumor progression. Congenital glioblastoma should be included in the differential diagnosis of infants with large intracranial tumors. Although surgical intervention may increase survival, the overall outcome remains poor despite maximal multimodal treatment.
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PMID:Congenital glioblastoma multiforme: case report and review of the literature. 1850 17