Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023380 (
lethargy
)
5,697
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The characterized nuclear cyclic AMP responsive element (CRE)- and
activator protein 1
(
AP-1
) DNA-binding activities in various brain regions of
lethargic
(lh/lh) mice, a genetic model of absence seizures. Gel-shift assays showed that nuclear CRE- and
AP-1
DNA-binding activities in the thalamus and cerebral cortex, but not in other regions such as the hippocampus and cerebellum of
lethargic
mice were significantly higher than those of non-epileptic control mice. Furthermore, CRE- and
AP-1
DNA-binding activities in
lethargic
mice, but not control mice, were inhibited by the specific GABA(B) receptor antagonist CGP 46831, at a dose which suppressed seizure behavior and spike and wave discharges. These results suggest that enhanced nuclear CRE- and
AP-1
DNA-binding activities in the thalamocortical region are related to generation and/or propagation of absence seizures in
lethargic
mice.
...
PMID:Characterization of absence seizure-dependent cyclic AMP responsive element-and activator protein 1 DNA-binding activities in lethargic (lh/lh) mice. 1007 71
To characterize seizure-associated increases in cerebral cortical and thalamic cyclic AMP responsive element (CRE)- and
activator protein 1
(
AP-1
) DNA-binding activities in
lethargic
(lh/lh) mice, a genetic model of absence seizures, we examined the effects of ethosuximide and CGP 46381 on these DNA-binding activities. Repeated administration (twice a day for 5 days) of ethosuximide (200 mg/kg) or CGP 46381 (60 mg/kg) attenuated both seizure behavior and the increased DNA-binding activities, and was more effective than a single administration of these drugs. These treatments did not affect either normal behavior or basal DNA-binding activities in non-epileptic control (+/+) mice. Gel supershift assays revealed that the increased CRE-binding activity was attributable to activation of the binding activity of CREB, and that the c-Fos-c-Jun complex was a component of the increased
AP-1
DNA-binding activity.
...
PMID:Repeated administration of CGP 46381, a gamma-aminobutyric acidB antagonist, and ethosuximide suppresses seizure-associated cyclic adenosine 3'5' monophosphate response element- and activator protein-1 DNA-binding activities in lethargic (lh/lh) mice. 1113 64
