Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Severe renal oxalosis was diagnosed in 4 male and 1 female purebred Beefmaster calves from herds in southeastern and northwestern United States. Clinical signs included weakness, anorexia, lethargy, alopecia, dehydration, and diarrhea. Results of serum biochemical analysis for 2 calves were consistent with end-stage renal disease. Calves died 2 days to 6 weeks after birth. At necropsy, renal calyces were dilated and contained pale yellow granular calculi. Histologically, there was renal interstitial fibrosis, and cortical and medullary tubules were distended with calcium oxalate crystals. Oxalate crystals were also in the tracheal glands of 1 calf. Severe renal oxalosis in young purebred calves, on widely varied diets, with no known exposure to exogenous oxalates is suggestive of an inherited metabolic defect resulting in primary hyperoxaluria.
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PMID:Severe renal oxalosis in five young Beefmaster calves. 148 14

A 12-month-old girl with end-stage renal disease secondary to primary oxalosis was erroneously given an overdose of sodium chloride (400 mEq NaCl over 12 h) to treat hyponatremia. She became lethargic and hypotonic with signs of intracellular dehydration, and laboratory values revealed severe hypernatremia and hyperchloremia. Since hypernatremia was acute and development of intracellular idiogenic osmoles was presumably minimal, serum sodium was lowered rapidly over 14 h by hourly peritoneal dialysis using a commercial dialysate. This method of treatment proved to be safe and the patient survived without any short or long-term neurological sequelae.
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PMID:Rapid correction of acute salt poisoning by peritoneal dialysis. 315 38