Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

George Carmichael Low, like so many early pioneers of Tropical Medicine, had his origin(s) in Scotland. Following a distinguished undergraduate (and early postgraduate) career, he joined Dr Patrick Manson at the newly established London School of Tropical Medicine in 1899. His first major contribution to the specialty (in 1900) was to demonstrate filariae in the proboscis sheath of mosquitoes which had been infected with Filaria bancrofti in Australia, using a technique recently learned in Heidelberg and Vienna. Shortly afterwards, he led an expedition to the Roman Campagna; this established beyond doubt mosquito-transmission of Plasmodium vivax infection to Homo sapiens. In 1901-1902, Low undertook a demanding tour of the Caribbean where he made important contributions to the understanding of the filariases, and assisted in malaria eradication. In 1902 he led a small team (the Royal Society's first sleeping sickness expedition) to investigate the 'negro lethargy' which had emerged in epidemic proportions on the northern shores of Lake Victoria in East Africa. This expedition narrowly failed to establish the aetiological agent (Trypanosoma sp.) of this disease. Following his return to London, Low became superintendent of the Albert Dock Hospital and from then onwards devoted most of his career to the London School of Tropical Medicine and the Hospital for Tropical Diseases (where he became senior physician). He wrote extensively, in addition to his clinical, teaching and administrative commitments. Perhaps Low's major contribution, however, was in establishing the Society (later Royal) of Tropical Medicine and Hygiene in 1907, with Mr (later Sir) James Cantlie.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Royal Society of Tropical Medicine and Hygiene meeting at Manson House, London, 10 December 1992. George Carmichael Low FRCP: twelfth president of the Society and underrated pioneer of tropical medicine. 824 57

A 4-year-old boy from the United States had been staying in Indonesia for five months when he presented with fever, severe lethargy, progressive weight loss, and abdominal distension. He was first diagnosed with Plasmodium vivax infection in Indonesia and received treatment with chloroquine. However, his condition continued to deteriorate and he required erythrocyte transfusion for severe anemia. Three weeks into his illness, he was found to have low parasitemia with Plasmodium falciparum with massive hepatosplenomegaly in Singapore. A splenic infarct was also documented on computed tomography. Treatment with atovaquone-proguanil resulted in stabilization of the hemoglobin level and rapid reduction in splenic size, with clearance of malarial parasites from the bloodstream. Although reported typically in adult tropical residents, hyper-reactive malarial splenomegaly may occasionally be found in the pediatric traveler. Clinicians receiving children returning from the tropical regions should be aware of this potentially life-threatening complication of partially treated malaria.
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PMID:Hyper-reactive malarial splenomegaly and splenic infarct in a caucasian toddler. 2447 Sep 10