Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to study the therapeutic effects of the TCM drugs on senile dyssomnia, 121 such patients were randomly divided into a treatment group of 63 cases (given the TCM drugs) and a control group of 58 cases (given estazolam). The changes shown in the SDRS and HAMA scores and the other indexes were observed in both of the two groups to evaluate the therapeutic effects. The results showed that the effective rate was 76.3% in the treatment group, and it was 69.1% in the control group; and that the TCM drugs had better effects in improving such symptoms as lethargy, dry mouth, and rebound of insomnia. Therefore, it can be concluded that the effect of the TCM drugs isbetter for senile dyssomnia than that of the Western drug estazolam.
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PMID:TCM treatment for 63 cases of senile dyssomnia. 1588 23

Objectives. Sleep disturbance is a common feature of depression. Symptoms often persist after treatment of the depressive episode, representing a risk factor for relapse. There is a lack of data regarding the nature of sleep disturbance in depression in the UK. Methods. We surveyed patients' views about their depressive symptoms and associated sleep difficulties. We received 513 responses via postal questionnaire. Results. A total of 97% reported sleep difficulties during depression: symptoms of insomnia were more frequently reported than hypersomnia. Ninety-nine percent of those with sleep problems also reported daytime symptoms including lack of concentration, exhaustion and lethargy, no energy and feeling sleepy; 40% admitted napping during the day; 59% indicated that poor sleep greatly affected their quality of life (QOL); 34% considered it to be "very distressing"; 69% of respondents were taking antidepressant medication at the time (44% said it improved their sleep, 56% said it had no effect or worsened their sleep); 69% had sought extra treatment for their sleep problems. Conclusions. Sleep disturbance in depression is a common and distressing problem that seems relatively unresolved by treatment. There is a need for more successful management in order to improve QOL in these patients and reduce a factor in depressive relapse.
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PMID:NAPSAQ-1: National Patient Sleep Assessment Questionnaire in depression. 2494 22