Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Impairment in short-term memory and lingering deficit in psychomotor performance are but two of the acute cannabis intoxication components that may have long-term consequences. The former because it affects learning and the latter because it interferes with proper handling of motor vehicles. The most frequently observed complication of cannabis inebriation, however, is a short-lasting acute psychological disturbance with symptoms of panic, paranoid apprehension and personality disorganization. This type of reaction is often not dose-related, and could appropriately be termed "pathological intoxication". In addition to the acute effects of cannabis on mental performance and behaviour, this paper reviews the psychiatric consequences of chronic use and the accumulated evidence on organic toxicity associated with it: residual cognitive deficit, lethargic symptoms, cannabis psychosis, respiratory, gastro-intestinal and cardiovascular complications, as well as effects on immune response and gonadal functions, are discussed. Also included are reviews on the pharmacology and therapeutic potential of cannabinoids.
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PMID:[Effect of cannabis use on health]. 632 49

To determine the clinical presentation and manifestations of Paget's disease of the bone in patients older than 60 years, we reviewed the cases of 56 patients attending a bone clinic. Pain was the presenting symptom in 34 cases. It was attributed to the disease process in 21 cases, to osteoarthritis in 11, to trigeminal neuralgia in 1, and to osteosarcoma in 1. Other clinical manifestations included deformities (15 cases), diminished mobility and unsteady gait (9), hearing impairment (7), lethargy (4), diminished vision (3), cognitive deficit (3), sense of warmth in limbs (2), ill-fitting dentures (1), and fracture (1). We concluded that in patients older than 60 years, Paget's disease of the bone may present itself in a variety of ways, some of which may be mistakenly attributed to the "aging process" or some other disease. Furthermore, in this age group, osteoarthritis is responsible for the pain experienced by about one third of symptomatic patients.
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PMID:Clinical presentation of Paget's disease of the bone in older patients. 821 23

Application of liver transplantation to methylmalonic acidemia (MMAemia) is controversial because MMAemia is caused by a systemic defect of methylmalonyl-CoA mutase. The clinical courses of seven pediatric patients with MMAemia undergoing living donor liver transplantation (LDLT) were reviewed. Serum and urinary methylmalonic acid (MMA) levels were found to be significantly decreased after LDLT, whereas serum and urinary MMA levels did not return to normal in any patient. One patient died of sepsis 44 days after LDLT. The other six patients are currently doing well. All patients had preoperative history of acute metabolic decompensation and/or metabolic stroke. However, no episode of acute metabolic decompensation or metabolic stroke was observed postoperatively in any surviving patients. In the preoperative period, all patients showed lethargy and cognitive deficit, both of which were eradicated after LDLT in all surviving patients. Preoperatively, all patients were subjected to dietary protein intake restriction and tube feeding, and were administered several metabolism-correcting medications. The metabolism-correcting medications being administered remained mostly unchanged after LDLT, whereas protein restriction was liberalized and tube feeding became unnecessary in all surviving patients. In addition, physical and neurodevelopmental growth delay remained in all surviving patients during the observation period, which ranged from 4 to 21 months with a median of 10.5 months.
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PMID:Efficacy of living donor liver transplantation for patients with methylmalonic acidemia. 1790 73