Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 7 calves inoculated with Trypanosoma brucei and observed for 105 days, the minimal clinical signs were occasional lethargic periods associated with parasitemia. Rectal temperatures increased by postinoculation day (pid), 10, remained moderately high until PID 50 to 60, and then returned to base line. Moderate anemia occurred between PID 15 and 25. Slightly increased lymphocyte count with relative decrease in neutrophil count was found in 3 calves. Monocytosis of minimal degree occurred 14 days after parasitemia. Trypanosome counts of low level and irregular frequency were found throughout the infection. The average number of trypanosomes in blood was approximately 1,000/ml. Antibody titers, as determined by the indirect immunofluorescent antibody method, appeared on PID 22 and stayed at moderate levels. The immunoglobulin M first increased at PID 5 and remained high (av 216% of base line value) throughout infection, but immunoglobulin G was never increased. Histopathologic study revealed proliferative changes in the lymph nodes and spleen characteristic of humoral antibody (B-cell) response. Mononuclear cell infiltration (lymphocytes and plasma cells), eosinophols, and edema were common in the lymph nodes, spleen, liver, heart, brain, hypophysis, testes, kidney, skeletal muscle, adrenal gland, pancreas, and uterus.
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PMID:Clinical, serologic, and pathologic changes in calves with experimentally induced Trypanosoma brucei infection. 93 3

A case history is reported of a 29-year old patient who presented with a chronic illness characterized by lethargy, back pain, fever, and anemia. Evaluation disclosed the presence of a large pelvic mass which was confirmed as a tubo-ovarian abscess at surgery. Histological evaluation demonstrated involvement by Actinomyces species. The patient's illness is discussed as a complication of chronic IUD usage with reference to specific management for this emerging problem. Data from the National Fertility Study conducted in 1973 revealed that nearly 2 million married women in the US, ages 15-44, were using IUDs. Scott noted the serious potentially fatal complications associated with IUD use, including pelvic inflammatory disease (PID), uterine perforation, ectopic pregnancy, and spontaneous or septic abortion. The relative risk of PID among IUD users has been reported to be increased 2-12 fold over controls. The risk of infection appears to increase as the period of IUD use lengthens, but the risk associated with the use of copper IUDs may be slightly less than with plastic IUDs. Actinomycosis has traditionally been described in 3 anatomical regions, the cervicofacial, thoracic, and abdominal areas, but pelvic and genital disease has been recognized with increasing frequency over the past decade. The common denominator associated with the latter syndrome appears to be the concurrent presence of an IUD. The Actinomyces are gram positive, nonacid fast, anaerobic, obligate parasites which are classified somewhere between the true bacteria and the complete fungi. Actinomyces species are not generally considered part of the normal vaginal flora but rather are associated with the presence of a foreign body, most often an IUD. It is thought that the IUD causes the initial tissue injury which permits subsequent colonization by these organisms. It is not known whether orogenital contact is a means of transmission of Actinomyces to the lower genital tract of sexual partners. One might estimate that the overall rate of cytological detection of A. israelii in cervical smears of IUD users at about 10%. This incidence increases sharply in patients being evaluated for symptomatic pelvic infection. Conversely, in women with IUDs in place and Actinomyces demonstrable in cervical smears, PID is up to 4 times as common as in those who have negative smears. Antibiotic treatment should probably be dictated by the clinical setting. As a general guide, the threshold for treatment should be low, since the therapy is relatively benign and the extent to which colonization and tissue invasion may have occurred is unknown.
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PMID:Pelvic actinomycosis and usage of intrauterine contraceptive devices. 718 22

Pelvic congestion syndrome (PCS) is a cause of chronic pelvic pain in women and is defined as pelvic pain lasting for more than six months.The diagnosis of PCS is a challenging task for the gynaecologist. It can be due to many varied causes like endometriosis, adhesions, chronic pelvic inflammatory disease (PID), ovarian cyst, fibroids, pelvic varicosities. Radiology plays an important role in the diagnosis and management of PCS. Pelvic UltraSonography (PUS),transvaginal sonography (TVS) with doppler, Magnetic resonance imaging (MRI), computed tomography (CT) and ovarian venography are usually used in the diagnosis of this condition. We report a case of a 35-year-old multiparous patient with history of pain in lower abdomen, vaginal discharge and general lethargy for past three years who was diagnosed as a case of PCS based on typical TVS and Doppler findings.
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PMID:Role of trans vaginal ultrasound and Doppler in diagnosis of pelvic congestion syndrome. 2517 7