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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Yersinia pseudotuberculosis infection in the cat is described. Clinical findings included inappetence, lethargy, rapid emaciation, jaundice and an enlarged left kidney. Chronic pseudotubercular lesions were found in the kidneys and lungs and Yersinia pseudotuberculosis Type IIB was recovered from both sites.
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PMID:Yersinia pseudotuberculosis in the cat. 32 72

The clinical, clinicopathologic, and pathologic features of 119 cases of plague in cats from 1977 to 1988 in New Mexico were reviewed. Fifty-three percent were bubonic, 10% were pneumonic, 8% were septicemic, and 29% with neither buboes nor pneumonia were unclassified (but presumed septicemic). Three quarters of the lymphadenopathy was submandibular, and almost half of this was bilateral. One third of all cats had the triad of lethargy, anorexia, and fever in addition to buboes; one quarter had this triad plus abscesses. The overall mortality rate was 33%, with the greatest risk of death in pneumonic cases. For confirmatory diagnosis with a single laboratory test, fluorescent antibody was most frequently used (39% of cases). Cultures and passive hemagluttination titers were also used for confirmation. Gross and histologic findings depended on the type of plague, with Yersinia pestis organisms visualized in buboes of cats with bubonic plague and in the alveolar spaces and respiratory tubules of cats with pneumonic plague.
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PMID:Clinical, clinicopathologic, and pathologic features of plague in cats: 119 cases (1977-1988). 175 74

Two outbreaks of yersiniosis caused by Yersinia enterocolitica occurred in breeding colonies of red ruffed lemurs (Varecia variegata rubra) and black and white ruffed lemurs (Varecia variegata variegata) housed in outdoor enclosures during the winter breeding season and spring birth season, respectively. Seven of 11 animals at risk in the combined outbreaks became ill, and 3 died of acute to chronic infection. Clinical signs included anorexia, lethargy, diarrhea, abdominal pain, and hyperpyrexia. Necropsy findings included ulcerative enterocolitis and multifocal necrosis and abscess formation in mesenteric lymph nodes, liver, spleen, kidneys, and lungs. Histologically, lesions were characterized by necrotizing inflammation containing masses of basophilic bacteria. Yersinia enterocolitica serotype 0:2 was isolated from lesions. Neomycin sulfate given orally and chloramphenicol given intramuscularly were effective in treatment early in the course of the disease or in mild cases. In severe cases, lemurs did not respond to antibiotic and fluid therapy. Exposure to soil contaminated with infected rodent feces, stress, and behavioral factors in the ruffed lemur species are believed to have precipitated the infection.
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PMID:Yersinia enterocolitica infection in breeding colonies of ruffed lemurs. 651 81

Fatal Yersinia pseudotuberculosis infection was diagnosed in 3 bushbabies (Galago crassicaudatus) in a large prosimian colony. The clinical signs were diarrhea, dyspnea, hyperthermia, dehydration, and lethargy. Histologically, the disease was characterized by lesions of ulcerative enterocolitis, necrotizing hepatitis, splenitis, lymphadenitis, and nonsuppurative pneumonitis.
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PMID:Fatal Yersinia pseudotuberculosis infection in captive bushbabies. 700 3

Naturally acquired plague was diagnosed in 5 domestic cats. The cats apparently contracted the disease through contact with sylvatic rodents or their fleas in plague-enzootic areas. The diagnosis was confirmed by direct immunofluorescence and isolation of Yersinia pestis on culture of abscess material. Abscess formation, lymphadenitis, lethargy, and fever were consistent clinical findings.
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PMID:Feline plague in New Mexico: report of five cases. 734 69

Yersinia pestis infection was diagnosed in 3 dogs. Clinical signs included lethargy (3 dogs), pyrexia (2 dogs), and a purulent skin lesion in the cervical region (2 dogs). Yersinia pestis infection is a potentially fatal zoonotic disease of human beings. Human cases have resulted from contact with infected domestic cats; however, the risk of human infection from contact with infected domestic dogs is unknown. Dogs frequently are exposed to Y pestis in areas in which there are plague epizootics; however, clinical illness in dogs is rare. In the western United States, where Yersinia pestis is endemic, plague should be considered in the differential diagnosis when examining dogs with nonspecific fever and lethargy.
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PMID:Yersinia pestis infection in three dogs. 762 31

To determine if the Siberian polecat (Mustela eversmannii) represents a suitable model for the study of plague pathogenesis and prevention in the black-footed ferret (Mustela nigripes), polecats were exposed to 10(3), 10(7), or 10(10) Yersinia pestis organisms by subcutaneous injection; an additional group was exposed to Y. pestis via ingestion of a plague-killed mouse. Plague killed 88% of polecats exposed to Y. pestis (71% mortality in the 10(3) group, 100% mortality in the 10(7) and 10(10) groups, and 83% mortality in the mouse-fed group). Within the challenged group, mean day of death post-challenge ranged from 3.6 to 7.6 days; all polecats died on or before day 12 post-challenge. Animals receiving the lowest parenteral dose survived significantly longer than those receiving higher parenteral doses. Within challenged animals, mean survival time was lower in those presenting with significant weight loss by day 3, lethargy, and low fecal output; time to onset of lethargy and other signs was also related to risk of dying and/or plague dose. Six polecats developed serum antibody titers to the Y. pestis F1 protein. Three seropositive polecats survived the initial challenge and a subsequent exposure to a plague-killed mouse, while two seropositive animals later died. This study confirms that the Siberian polecat is susceptible to plague and suggests that this species will offer an appropriate surrogate for black-footed ferrets in future plague studies and related vaccine trials.
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PMID:Susceptibility of the Siberian polecat to subcutaneous and oral Yersinia pestis exposure. 1176 38

The development of disease following oral challenge with Yersinia pseudotuberculosis (serotype II) was compared in four groups of five chickens treated with a combination of 10 mg parenteral iron-dextran, 10 mg of the chelating agent desferrioxamine or 10 mg of dextran, 2 days before infection. The chickens pretreated with iron-dextran, with or without desferrioxamine, developed diarrhoea and were lethargic 2 days following bacterial challenge. Chickens not given iron-dextran showed no clinical signs of disease. Histological examination of selected tissues indicated that chickens pre-treated with iron-dextran had significantly more intestinal lesions, but fewer lesions in the spleen, than chickens in groups not treated with iron-dextran. In contrast to control chickens given iron dextran, but not challenged with bacteria, there was no stainable iron in the livers of chickens challenged with Y. pseudotuberculosis 10 days after an injection of 10 mg of iron-dextran. This suggests that chickens challenged with Y. pseudotuberculosis utilised exogenously administered iron during infection.
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PMID:The effect of parenteral iron dextran, with or without desferrioxamine, on the development of experimental pseudotuberculosis in the domestic chicken. 1848 18

Since the anthrax attacks of 2001, the emphasis on developing animal models of aerosolized select agent pathogens has increased. Many scientists believe that nonhuman primate models are the most appropriate to evaluate pulmonary response to, vaccines for, and treatments for select agents such as Yersinia pestis (Y. pestis), the causative agent of plague. A recent symposium concluded that the cynomolgus macaque (Macaca fascicularis) plague model should be characterized more fully. To date, a well-characterized cynomolgus macaque model of pneumonic plague using reproducible bioaerosols of viable Y. pestis has not been published. In the current study, methods for creating reproducible bioaerosols of viable Y. pestis strain CO92 (YpCO92) and pneumonic plague models were evaluated in 22 Indonesian-origin cynomolgus macaques. Five macaques exposed to doses lower than 250 CFU remained free of any indication of plague infection. Fifteen macaques developed fever, lethargy, and anorexia indicative of clinical plague. The 2 remaining macaques died without overt clinical signs but were plague-positive on culture and demonstrated pathology consistent with plague. The lethal dose of plague in humans is reputedly less than 100 organisms; in this study, 66 CFU was the dose at which half of the macaques developed fever and clinical signs (ED(50)), The Indonesian cynomolgus macaque reproduces many aspects of human pneumonic plague and likely will provide an excellent model for studies that require a macaque model.
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PMID:Clinical and pathologic features of cynomolgus macaques (Macaca fascicularis) infected with aerosolized Yersinia pestis. 1979 59

Yersinia enterocolitica (YE) bioserotype 1B/O:8 (YE 1B/O:8) was identified in routine culture of a variety of zoo species housed at Omaha's Henry Doorly Zoo and Aquarium (OHDZA) from April to July 2011. Animal cases representing 12 species had YE detected from 34 cases during routine fecal monitoring and/or during postmortem examination: Coquerel's sifakas (Propithecus coquereli, two cases), black & white (BW) ruffed lemurs (Varecia variegata variegata, six cases), red ruffed lemurs (Varecia rubra, seven cases), white handed gibbon (Hylobates lar albimana, one case), black lemurs (Eulemur macaco, three cases), mongoose lemurs (Eulemur mongoz, two cases), African hunting dogs (Lycaon pictus, five cases), agile gibbons (Hylobates agilis, three cases), siamangs (Hylobates syndactylus, two cases), colobus monkey (Colobus angolensis palliates, one case), argus pheasant (Argusianus argus, one case), and orangutan (Pongo pygmaeus, one case). Most species were not symptomatic; however, three symptomatic cases in Coquerel's sifakas (two) and a white handed gibbon (one) showed clinical signs of diarrhea and lethargy that resulted in death for the Coquerel's sifakas. One unexpected death also occurred in a BW ruffed lemur. To the authors' knowledge, this is the first report of YE 1B/O:8 in such a large variety of zoo species. The source of the YE could not be identified, prompting the initiation of a diseases surveillance program to prevent further cases for the species that are sensitive to YE. To date, no additional cases have been identified, thus suggesting a single introduction of the YE 1B/O:8 strain into the zoo environment.
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PMID:CLONAL SPREAD OF YERSINIA ENTEROCOLITICA 1B/O:8 IN MULTIPLE ZOO SPECIES. 3221 60


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