Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In some cultures semen loss is associated with illness, anxiety, and loss of energy and power. Thirty-five nonpsychotic patients attending a psychiatric clinic in Sri Lanka during one month, attributed their complaints of sexual dysfunction, lethargy, thinness, and miscellaneous aches and pains to semen loss resulting from masturbation or nocturnal emissions. Similar complaints are rare among psychiatric patients in Japan. A survey questionnaire designed to measure negative attitudes and beliefs regarding semen loss was used to measure such attitudes in a patient population and a general university population in Sri Lanka and Japan. The survey disclosed that unlike in Japan, people in Sri Lanka consider semen loss to be detrimental to mental and physical health. Attitudes regarding semen loss were the most negative in the patient population. These results indicate the possibility that culturally held negative attitudes and beliefs may contribute to the high incidence of semen-loss complaints in Sri Lanka, and suggest that attitudes and beliefs may play a role in the way patients express psychopathological symptoms in different societies.
 ...
PMID:Semen-loss syndrome: a comparison between Sri Lanka and Japan. 201 92

Venlafaxine is a serotonin-noradrenaline reuptake inhibitor (SNRI) that has no affinity for muscarinic, adrenergic or histaminergic receptors. In short-term trials, the adverse effects that occurred more often with venlafaxine than with placebo included nausea, somnolence, dizziness, dry mouth, and sweating. Rapid titration of the dose of venlafaxine to higher levels appeared, not unexpectedly, to be associated with an increased incidence of side effects. Side effects that appeared to be dose related included insomnia, nausea and sexual dysfunction. The incidence of nausea and dizziness was highest during the first 2 or 3 weeks of therapy and decreased rapidly thereafter. Somnolence also decreased over time. At high doses blood pressure increases were reported in a small percent of patients on venlafaxine and antidepressant drugs but were uncommon at the venlafaxine dose of 75-150 mg daily. Studies with venlafaxine in healthy volunteers indicate a low potential for drug-drug interactions. Overdoses have been reported in 14 of 3,082 patients administered venlafaxine in clinical trials, and no deaths were reported among these patients. Overdoses of venlafaxine induced mainly drowsiness and lethargy.
 ...
PMID:Neurobiologic basis of antidepressant safety profiles. 1969 84

Patients with invasive giant prolactinoma suffer from a constellation of symptoms including headache, blurred vision, lethargy, and sexual dysfunction. Cabergoline, a potent dopamine agonist, is a known medication prescribed for the treatment of invasive giant prolactinoma. Here, we report a case of invasive giant prolactinoma in a 52-year-old Saudi male with dramatic response to cabergoline treatment clinically, biochemically, and radiologically.
...
PMID:Cabergoline treatment in invasive giant prolactinoma. 2500 19