Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 10-year-old, male beagle was presented for lethargy, anorexia, and straining to urinate. A mass was palpated in the caudal abdomen in the area of the bladder. Abdominal radiography revealed a gas-filled mass in the caudoventral abdominal quadrant. Subsequent positive-contrast cystography revealed that the mass was caudal to the bladder. Abdominal exploratory celiotomy resulted in the drainage of a prostatic abscess containing gas. The histopathological diagnosis of the prostate was a poorly differentiated tubular carcinoma with necrosis. To the authors' knowledge, this article is the first report of an emphysematous prostatitis in a dog.
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PMID:Emphysematous prostatitis and carcinoma in a dog. 1222 33

A previously healthy 21-year-old man presented with an 8-month history of weight loss, lethargy and dysuria unresponsive to empiric antibiotics and paraurethral drainage of a prostatic abscess. Urinalysis showed pyuria, but cultures failed to grow any organisms. Additionally, he developed new onset sensorineural hearing loss. CT of the chest showed two right-sided cavitary lesions. CT of the abdomen and pelvis demonstrated a prostatic abscess. A prostate biopsy demonstrated necrotising granulomatous prostatitis. A lung biopsy showed necrotising granulomatous inflammation. He was diagnosed with granulomatosis with polyangiitis (GPA). He was successfully treated with rituximab and prednisone. At 6-month follow-up, he continued to be in remission with resolution of his symptoms. This case demonstrates a rare presentation of prostatitis as the presenting symptom of GPA. As far as we know, this case is the first documented report of rituximab and prednisone as successful therapy for prostatitis secondary to GPA.
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PMID:Prostatitis, a rare presentation of granulomatosis with polyangiitis, successfully treated with rituximab and prednisone. 3010 18