Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hematological parameters, plasma C-reactive protein (CRP), and tumor necrosis factor alpha were analyzed in 64 dogs with a presumptive diagnosis of pyometra. Final diagnosis (i.e., pyometra or cystic endometrial hyperplasia [CEH]) was determined by histopathology. As a single test, the percentage of band neutrophils had the highest sensitivity in the prediction of pyometra (sensitivity, 94%). The combination of percentage of bands and CRP had the highest sensitivity (97.7%; specificity, 75%) in predicting the presence of pyometra. The most common clinical signs noted in the study were vaginal discharge, polyuria, polydipsia, lethargy, and gastrointestinal signs. A combination of three or more of these clinical signs was significantly associated with pyometra.
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PMID:C-reactive protein in the differentiation of pyometra from cystic endometrial hyperplasia/mucometra in dogs. 1534 19

An unusually high prevalence of uterine changes was observed on necropsy in a group of 169 female Seba's short-tailed bats (Carollia perspicillata). In this case study, 27 animals were affected from 1997 to 2007, representing 16% of the group population. All bats were of an indeterminate age and originated from the same facility, but were housed in three different zoological institutions. Deaths occurred year round. Most animals were found dead, with no previous clinical signs. Clinical signs, when present, included a markedly distended abdomen, extended periods of time perched on the exhibit floor, lethargy, and anorexia. Histologic changes included florid segmental to diffuse endometrial hyperplasia and occasional hemorrhage and adenomyosis. The cause for this condition has not been determined.
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PMID:Proliferative endometrial lesions in a group of Seba's short-tailed bats (Carollia perspicillata). 1974 57

A 9-year-old bitch was presented because of lethargy and abdominal distension. Abdominal ultrasound revealed an enlarged, fluid-filled uterus and associated mass. Subsequent exploratory laparotomy revealed unilateral uterine torsion involving the mass. Recovery following ovariohysterectomy was uneventful and the histopathological diagnosis was of a benign endometrial inflammatory polyp. Reports of uterine torsion in the English-language literature are reviewed to identify factors associated with the incidence of uterine torsion. The aetiology of the cystic endometrial hyperplasia/pyometra complex and its possible role in the development of inflammatory polypoid lesions in the bitch is also discussed.
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PMID:Unilateral uterine torsion secondary to an inflammatory endometrial polyp in the bitch. 2193 64

Pyometra and cystic endometrial hyperplasia are common in domestic canids and are suspected to develop as a consequence of elevated progesterone levels. Reports of uterine pathology in exotic canids are limited, with some speculating of association with contraception. This report describes pyometra, cystic endometrial hyperplasia, and ovariohysterectomy in three African hunting dogs (Lycaon pictus). Ovarian corpora lutea were detected in two of the dogs, suggesting endogenous progesterone production. One dog had a uterine adenocarcinoma and two had ovarian granulosa cell tumors. Clinical signs included anorexia, lethargy, vulvar discharge, polyuria, polydipsia, and abdominal distention. Diagnosis was based on clinical signs, physical examination, bloodwork, radiography, and ultrasonography, with confirmation through histopathologic evaluation of tissues. Cystic endometrial hyperplasia, pyometra, and uterine neoplasia have rarely been diagnosed in exotic canids; however, they should be considered as differential diagnoses in intact bitches that present with suspected reproductive disease.
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PMID:Cystic endometrial hyperplasia and pyometra in three captive African hunting dogs (Lycaon pictus). 2244 15