Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Septic arthritis in infants who are less than two months of age is a rare condition. During a recent seven-year period, eighteen cases of infantile septic arthritis were diagnosed at Mackay Memorial Hospital. The ratio of males to females was 1.6:1. The most common symptoms were crying during diaper change, and an immobile and swollen joint. Nonspecific symptoms such as fever, poor appetite and lethargy were uncommon. The hip was the most commonly affected joint with the knee taking second place. Ten cases (55%) demonstrated concomitant osteomyelitis. A bacterial etiology was established in 16 cases (88%). The predominant pathogens were S. aureus (5 cases) followed by group B streptococcus (4 cases). Total parenteral nutrition was the predisposing factor of infection in 4 of the 5 S. aureus arthritis cases. The duration of treatment ranged from 21 to 44 days. Two patients developed sequelae: namely discrepancies in leg length, and a limping gait. Early diagnosis and prompt antibiotic treatment are crucial elements in the prevention of disabling and catastrophic sequelae in young infants who have septic arthritis. In addition, open drainage is highly recommended in hip and shoulder arthritis.
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PMID:Septic arthritis in early infancy. 227 68

A 7-year-old castrated male German Shepherd Dog was evaluated for lethargy, icterus, and sepsis. Porcupine quills had been removed from the dog's face 1 month prior to examination; progressive right forelimb lameness had developed soon after removal of the quills. Septic arthritis of the right elbow joint was diagnosed and was unresponsive to antimicrobial and anti-inflammatory treatments. At the time of referral, the dog had developed endocarditis, septicemia, and disseminated intravascular coagulation. Via ultrasonography, a foreign body consistent with a porcupine quill was detected in the medial portion of the right humeroradial joint. The dog did not respond to initial supportive treatment and died as a result of cardiac arrest. Postmortem examination confirmed the presence of a quill in the medial compartment of the right elbow joint and severe acute endocarditis with septic emboli to the kidneys and spleen. Ultrasonographic examination should be considered as a diagnostic tool when septic arthritis secondary to a foreign body is suspected in dogs.
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PMID:Ultrasonographic diagnosis of septic arthritis secondary to porcupine quill migration in a dog. 1512 88