Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023380 (lethargy)
 5,697 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It was the purpose of this work to verify the hypothesis of Poskanzer and Schwab according to which nearly all cases of parkinsonism are consequences of clinical and subclinical lethargic encephalitis in the years 1917-1926. The investigated material included 495 patients with parkinsonism treated at the neurological hospital departments in Warsaw in the years 1967-1976 and 263 patients living in the City of Warsaw and treated as outpatients or inpatients in the years 1972-1976. The control group comprised patients with amyotrophic lateral sclerosis treated in the Warsaw hospitals in the years 1967-1976. The correlation between the mean age at the time of disease onset and the calendar year of disease onset was studied in different groups of patients. The indices of disease prevalence, first visits and mortality were calculated in the group of patients living in the City of Warsaw. Low values of correlation indices and persistence of approximately unchanged indices of first visits and mortality in the years 1972-1976 failed to confirm the hypothesis of Poskanzer and Schwab.
 ...
PMID:[Etiology of parkinsonism. A verification of Poskanzer's and Schwab's hypothesis]. 51 36

Selenium is a metalloid of considerable interest in the human from both a toxicological and a nutritional perspective, with a very narrow safe range of intake. Acute selenium intoxication is followed by adverse effects on the nervous system with special clinical relevance, while the neurotoxicity of long-term overexposure is less characterized and recognized. We aimed to address this issue from a public health perspective, focusing on both laboratory studies and the few epidemiologic human studies available, with emphasis on their methodological strengths and limitations. The frequently overlooked differences in toxicity and biological activity of selenium compounds are also outlined. In addition to lethargy, dizziness, motor weakness and paresthesias, an excess risk of amyotrophic lateral sclerosis is the effect on the nervous system which has been more consistently associated with chronic low-level selenium overexposure, particularly to its inorganic compounds. Additional research efforts are needed to better elucidate the neurotoxic effects exerted by selenium overexposure.
...
PMID:Selenium neurotoxicity in humans: bridging laboratory and epidemiologic studies. 2426 18

A patient with lower-limb onset ALS presented with a one-month history of vasovagal episodes and a one-week history of cough productive of green sputum and lethargy. She was drowsy and in acute on chronic type-two respiratory failure. She responded to non-invasive ventilation, however she suffered recurrent episodes of profound bradycardia on removal of the mask, which gradually resolved over ten days. We have reviewed the literature and offer a potential explanation for these events.
...
PMID:Profound bradycardia associated with NIV removal. 2605 81

Only a few cases of syndrome of inappropriate antidiuretic hormone secretion (SIADH) in the setting of amyotrophic lateral sclerosis (ALS) have been described in the literature. We present the case of an 81-year-old male who developed severe hyponatremia following elective total hip replacement. His past medical history included prostate cancer, which was under surveillance, and ischemic heart disease. He reported recent weight loss, worsening shortness of breath, and lethargy. SIADH was diagnosed on the basis of hyponatremia, elevated urinary sodium, and decreased serum osmolality, presumed secondary to surgery. Investigations revealed no occult malignancy and no other cause for hyponatremia. He was discharged when sodium levels had normalized, however, he then had several further admissions for hyponatremia, general fatigue, and breathlessness. His condition continued to decline, and he developed dysphagia, weakness, and tongue fasciculations. Neurological examination showed globally decreased power, increased tone, and fasciculations. MRI of the brain was normal. He did not respond to neostigmine treatment, and a presumed diagnosis of motor neuron disease was made. The patient passed away shortly after this, and a post-mortem confirmed the diagnosis of ALS. Drug, post-operative, and cancer-related causes were precluded by the timing of onset of hyponatremia. We present this case and an analysis of previously published cases alongside a discussion on the potential causative mechanisms.
 ...
PMID:Inappropriate antidiuretic hormone secretion in amyotrophic lateral sclerosis. 3244 77