Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023241 (Legionella)
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Human Gene/Protein
CNR7 12.2
TMEM86B 12.2
C1orf43 11.2
Regulator of chromosome condensation 1 11.2
RABIF 10.2
MORN2 10.2
TRBV28 9.8
FEZ 9.8
Oculocerebrorenal syndrome of Lowe 9.5
UBE2W 9.3
IL-12 receptor beta 2 9.3
TRAJ33 9.2
SUPT5H 9.2
MDP-1 9.0
putative N-acetyltransferase 9.0
MIL1 9.0
eight membrane-spanning domains 8.8
Bcl-rambo 8.8
SAM50 8.6
IPAF 8.4
mono-ADP-ribosyltransferase 8.4
NLRC4 8.4
NRK1 8.3
Rab30 8.3
Active regulator of SIRT1 8.3
CYS1 8.2
HGN 8.2
La-related protein 7 8.2
FAPP1 8.1
PIPK 8.0
coronin-1 7.9
syntaxin 17 7.9
H63 7.9
CHC22 7.9
AARS 7.9
TBC1D5 7.8
AZI 7.8
LGALS8 7.8
ATP6AP1 7.7
FKBP22 7.7
RAB14 7.7
peptidylprolyl cis-trans isomerase 7.7
NAIP 7.7
KIAA1109 7.6
UBC13 7.6
ST1 7.6
VPS29 7.5
Coronin-1A 7.5
BRAG2 7.5
IRG1 7.5
RAB10 7.4
lysophospholipase 7.3
ARHGEF9 7.2
DLM-1 7.2
P145 7.2
Nod1 7.1
ENX 7.1
Rabaptin-5 7.1
N-acetylglutamate synthetase 7.1
PRKAA 7.1
liver-expressed antimicrobial peptide 2 7.1
peptidyl prolyl cis-trans isomerase 7.1
GDI-1 7.0
p-hydroxyphenylpyruvate dioxygenase 7.0
hVDAC1 6.9
CASP-1 6.9
ankyrin repeat-containing protein 6.9
regulator of chromosome condensation 1 6.9
RC1 6.9
KHS 6.9
ARP3 6.9
GDP dissociation inhibitor 6.9
EF1A 6.8
OCRL1 6.8
UBE2D3 6.8
FCN2 6.8
CCT5 6.8
collagen-like protein 6.8
PPIase 6.8
TOLLIP 6.8
MARCH1 6.8
ACP2 6.7
ACF1 6.7
STX17 6.7
adenylyl cyclase-associated protein 6.6
atlastin-1 6.6
ASB 6.6
NMNAT1 6.6
tetratricopeptide repeat protein 6.5
GMP synthase 6.5
GBP2 6.5
sphingosine-1-phosphate lyase 6.5
sorting nexin 1 6.5
LAMP-1 6.5
SGPL1 6.5
diubiquitin 6.5
Jac1 6.5
ferritin repressor protein 6.5
GDP-dissociation inhibitor 6.4
MICAL 6.4
BAT3 6.4
Transcription factor 21 6.4
syntaxin 3 6.4
D-3-phosphoglycerate dehydrogenase 6.4
LRG-47 6.4
SLP1 6.4
4-hydroxyphenylpyruvate dioxygenase 6.4
LAMP-2 6.4
putative transmembrane protein 6.3
nuclear pore protein 6.3
FK506-binding protein 6.3
Ankyrin 6.3
Signal transducer and activator of transcription 1 6.3
neuronal apoptosis inhibitory protein 6.3
SHK 6.2
galectin-8 6.2
Toll-interacting protein 6.2
RanBP1 6.2
S53 6.2
EMB 6.2
SDPR 6.2
serine dehydratase 6.1
NCK1 6.1
MOB1 6.1
BIG1 6.1
proline isomerase 6.1
GAP protein 6.1
MLTF 6.1
VAMP4 6.1
SAMDC 6.0
ULK2 6.0
Rab GTPase 6.0
DDX41 6.0
Tre-2 6.0
phosphoglyceromutase 6.0
Phenylalanine hydroxylase 6.0
Rabex-5 5.9
Nramp 5.9
BMH 5.9
Stat2 5.9
DNM1L 5.9
putative ATPase 5.9
SNL 5.9
rotamase 5.9
CASP11 5.9
FRAXE 5.9
440 kDa 5.9
ACAP 5.8
OTUB1 5.8
PRSP 5.8
Zinc finger protein 5.8
macrophage receptor with collagenous structure 5.8
O-acetyltransferase 5.8
HYP 5.8
gasdermin 5.8
ANK 5.8
ZBP1 5.7
CASP4 5.7
H. influenzae 5.7
CG1 5.6
more...
Disease
Legionella 12.2
Pontiac fever 12.0
legionellosis 11.9
Legionella micdadei 11.6
Legionella pneumophila pneumonia 10.8
Bronchopulmonary disease 10.2
Endogenous lipoid pneumonia 9.6
Delayed delivery 9.6
Influenza B virus infection 9.6
atypical pneumonia 9.4
Chlamydia pneumoniae pneumonia 9.2
Haemophilus influenzae pneumonia 9.0
Herpes simplex type I 9.0
community acquired pneumonia 9.0
Coxiella infection 8.8
Listeria sepsis 8.8
Parapneumonic effusion 8.6
Granulocytosis 8.3
Acute respiratory tract infection 8.3
Acute pneumonia 8.2
Herpes simplex 1 8.0
Disseminated toxoplasmosis 7.9
Febrile illness 7.8
Secondary bacterial pneumonia 7.6
neuromyasthenia 7.6
Soft tissue infection 7.6
Nosocomial pneumonia 7.5
Pneumococcal infection 7.4
Q fever pneumonia 7.4
Pulmonary infiltrates 7.3
psittacosis 7.3
bacterial pneumonia 7.3
lobar pneumonia 7.2
Mycoplasma pneumoniae pneumonia 7.2
Mycoplasma 7.1
pneumonia 7.1
Chlamydia 7.0
chronic endocarditis 7.0
Chlamydia psittaci infection 7.0
Escherichia coli pneumonia 6.9
lung abscess 6.9
Ventilator associated pneumonia 6.8
public drinking 6.8
reticular dysgenesis 6.8
Listeria meningitis 6.5
Pseudomonas septicemia 6.5
Q fever 6.5
Brazilian purpuric fever 6.5
pseudomembranous enterocolitis 6.4
Pulmonary infection 6.4
Subclinical infection 6.3
Prosthetic valve endocarditis 6.3
splenitis 6.3
Adrenal hemorrhage 6.3
Haemophilus 6.3
chest infection 6.1
Haemophilus influenzae meningitis 6.0
sick building syndrome 6.0
Toxoplasma infections 6.0
West Nile encephalitis 6.0
FIH 6.0
postpericardiotomy syndrome 6.0
NML 5.9
BMH 5.9
viral pneumonia 5.8
pityriasis rosea 5.7
VDI 5.7
pleuropericarditis 5.7
Bordetella 5.7
Transverse myelitis 5.6
Norwegian scabies 5.5
nosocomial infection 5.5
Pneumocystis carinii infection 5.5
Brucella suis 5.5
Sever 5.5
Acute interstitial nephritis 5.4
Brucella melitensis 5.4
marijuana abuse 5.4
chlamydial urethritis 5.4
Chlamydia pneumoniae infection 5.4
bronchopneumonia 5.4
herpangina 5.4
Chronic lung disease 5.4
BCD 5.3
Acanthamoeba keratitis 5.3
Shwartzman reaction 5.3
respiratory infection 5.3
WS1 5.3
Rotor 5.3
Lowe syndrome 5.3
HMR 5.2
Marburg virus disease 5.2
streptococcal pharyngitis 5.2
Infections 5.2
DIN 5.2
DIN 5.2
primary amebic meningoencephalitis 5.1
Acute respiratory infections 5.0
pulmonary infarction 5.0
Mixed infection 5.0
Eosinophilic fasciitis 5.0
IVA 5.0
RP4 5.0
typhus 5.0
Q fever endocarditis 4.9
Parainfluenza 4.9
MLS 4.9
Fusarium infection 4.9
Yersinia 4.9
chronic bronchitis 4.9
Shigella 4.8
lymphoblastoma 4.8
bronchomalacia 4.8
Pneumocystis jiroveci pneumonia 4.8
VES 4.8
Shigella flexneri 4.8
pharyngitis 4.7
Clostridium difficile colitis 4.7
tularemia 4.7
CMV colitis 4.7
Sampson 4.7
bacterial conjunctivitis 4.7
EIA 4.7
lymphogranuloma venereum 4.7
chronic enteritis 4.6
Occupational asthma 4.6
chancroid 4.6
aspiration pneumonia 4.6
infectious gastroenteritis 4.6
croup 4.5
RP1 4.5
Mycobacterium 4.5
Infection 4.5
hypersensitivity pneumonitis 4.5
occupational lung disease 4.5
inclusion conjunctivitis 4.5
HOPS 4.4
bacillary dysentery 4.4
Klebsiella 4.4
TNS 4.4
Invasive pulmonary aspergillosis 4.4
tracheobronchitis 4.3
Brucella abortus 4.3
acute alcoholic hepatitis 4.3
upper respiratory infection 4.3
tonsillitis 4.3
glomerulitis 4.3
Acute infection 4.3
cerebral abscess 4.3
acute pericarditis 4.3
Pseudomonas infection 4.3
giardiasis 4.2
hypochloremia 4.2
Campylobacter enteritis 4.2
melioidosis 4.2
respiratory failure 4.1
Cat scratch disease 4.1
bacterial infection 4.1
otitis externa 4.1
pseudomembranous colitis 4.1
more...
Symptom
Gastrointestinal distress 8.6
Mental status changes 7.9
epigastric distress 7.6
pleuritic chest pain 6.3
non-productive cough 6.0
Neurologic symptoms 5.6
Visual disturbances 5.3
productive cough 5.0
throat irritation 4.7
flushing 4.6
persistent cough 4.5
rales 4.4
chills 4.3
Respiratory symptoms 4.3
chest tightness 4.2
twitching 4.2
cough 4.1
rigors 4.1
ataxic gait 4.0
loin pain 3.8
intention tremor 3.7
microbial colonization 3.7
prostration 3.6
sore throat 3.5
consciousness disturbance 3.5
Halo 3.3
tenesmus 3.3
otalgia 3.2
respiratory distress 3.1
myalgia 3.1
dyspnea 3.0
excessive sweating 3.0
Ill 3.0
night sweats 2.9
oliguria 2.9
dysarthria 2.9
hemoptysis 2.7
fever of unknown origin 2.7
shortness of breath 2.6
renal colic 2.5
tachypnea 2.4
diarrhea 2.4
starvation 2.4
DNA marker 2.3
wheezing 2.2
hoarseness 2.2
apathy 2.2
hypoproteinemia 2.0
stridor 2.0
headache 1.9
dysuria 1.9
tonic-clonic seizure 1.8
paraparesis 1.7
nausea 1.6
exertional dyspnea 1.4
hip pain 1.3
cerebellar ataxia 1.3
memory loss 1.3
chest pain 1.1
flank pain 1.1
rhinorrhea 1.0
abdominal pain 0.9
hyperoxia 0.8
anorexia 0.7
vomiting 0.7
HSA 0.6
acute abdomen 0.6
ataxia 0.5
sleepiness 0.5
splenomegaly 0.5
weakness 0.4
arthralgia 0.3
neck pain 0.2
myoclonus 0.1
fatigue 0.1
hepatosplenomegaly 0.0
tremor -0.0
collapse -0.1
dizziness -0.1
acidity -0.1
numbness -0.2
discomfort -0.3
hepatomegaly -0.3
hypotonia -0.4
agitation -0.4
discomfort -0.4
exhaustion -0.6
hypercapnia -0.8
hypothermia -0.9
nausea and vomiting -1.1
low back pain -1.1
constipation -1.2
back pain -1.4
erythema -1.5
seizures -1.6
pain -1.9
anesthesia -2.0
Drug
C20H30O2 10.6
Oxendolone 8.8
Cefditoren pivoxil 8.7
TFLX 8.6
Dirithromycin 8.2
Ziracin 8.2
ENX 7.8
SPFX 7.8
Avelox 7.6
Miocamycin 7.4
Gemifloxacin 7.3
Chloramine T 7.3
Synercid 7.3
Cinnamon oil 7.1
Gatifloxacin 6.9
Arlacel 6.9
CPFX 6.9
SBT 6.9
Tosufloxacin 6.8
naladixic acid 6.7
Azithromycin 6.7
NFLX 6.6
DOXY 6.5
Ofloxacin 6.4
OFLX 6.2
Sitafloxacin 6.2
Sulla 6.2
Pefloxacin 6.1
EMB 6.1
Cefditoren 6.1
Sterile water 6.0
CPFX 5.9
Vibramycin 5.9
Propidium 5.7
EML 5.7
MINO 5.7
SNL 5.6
Moxifloxacin 5.6
Imuran 5.5
CG1 5.5
Saha 5.1
Rhamnose 5.0
Doxycycline 4.6
Cefaclor 4.6
PPA 4.5
Abatacept 4.5
C3H6 4.5
Survanta 4.4
OMP 4.3
Giardiasis 4.3
IPM 4.2
9-THC 4.2
Zinat 3.6
Trimethoprim-sulfamethoxazole 3.6
CDP 3.5
Doyle 3.5
Ceftazidime 3.5
MDM 3.5
ampicillin 3.4
Epigallocatechin 3.3
Amoxicillin 3.3
anti-RSV 3.3
CSI 3.3
MRC 3.2
AraC 3.1
Meropenem 3.0
CPM 2.9
RFP 2.9
Oseltamivir 2.9
Meropenem 2.8
ACT 2.7
IFN-beta 2.6
MgSO4 2.6
Methylprednisolone 2.3
NVP 2.2
IFN-gamma 2.1
Acyclovir 2.1
OTC 2.1
AMC 1.9
L-tyrosine 1.9
TAT 1.9
CTC 1.8
FeCl3 1.7
Ranitidine 1.5
Cimetidine 1.5
TAC 1.5
Cimetidine 1.5
Glutathione 1.3
Monit 1.3
PCP 1.3
Fluorescein 1.3
Check 1.2
uPA 1.1
ABC 1.0
MDS 1.0
lysine 1.0
Glycerol 1.0
Fragment 1.0
EPA 0.9
Gel 0.9
Ouabain 0.9
Nitric Oxide 0.8
Alliance 0.8
Fluorescein 0.8
Alanine 0.7
CSF 0.6
Heme 0.6
CaCl2 0.5
CaCl2 0.5
CaCl2 0.5
Retinoic acid 0.4
TiO2 0.3
Asn 0.2
DNase I 0.1
citric acid -0.1
Asthma -0.2
NADH -0.3
CAM -0.4
Bifidobacterium -0.4
SiO2 -0.4
Mutagen -0.4
Nephron -0.4
IL-2 -0.7
ROC -0.8
lactose -0.9
ENT -0.9
nitroglycerin -1.0
Ethanol -1.1
ZnO -1.6
Dial -1.7
MAP -1.8
Nephron -2.0
ROS -2.1
Leaf -2.3
ascorbate -2.3
Dermatol -3.5
Cardiovasc -4.5
Enzyme
protease do 10.6
phosphatidylcholine synthase 10.5
5-methylthioribose kinase 9.2
lysoplasmalogenase 9.0
prepilin peptidase 8.7
phosphoamidase 8.5
tail-specific protease 7.9
caspase-11 7.6
caspase-11 7.6
homospermidine synthase 7.2
phosphoglucosamine mutase 7.0
indoleglycerol phosphate synthase 6.9
N-acetylglucosamine 2-epimerase 6.9
GMP synthase 6.4
4-hydroxyphenylpyruvate dioxygenase 6.3
L-serine dehydratase 6.3
neuropathy target esterase 6.3
phosphopentomutase 6.2
6-phosphogluconate dehydratase 6.2
signal peptidase II 6.1
SirA 6.0
pseudolysin 5.9
caspase-5 5.9
LipB 5.9
peptidyl-prolyl cis-trans isomerase 5.9
phosphoglycerate dehydrogenase 5.8
LasR 5.8
2-keto-3-deoxy-6-phosphogluconate aldolase 5.7
caspase-5 5.6
N-acetylglutamate synthase 5.4
caspase-4 5.2
peptide deformylase 5.2
caspase-1 5.2
HtrA 5.1
caspase-4 5.1
LipA 4.9
GMP synthetase 4.9
N-acetylglutamate synthase 4.9
deoxyhypusine synthase 4.9
MsrA 4.8
oxaloacetate decarboxylase 4.8
caspase-7 4.7
caspase-7 4.6
homogentisate 1,2-dioxygenase 4.6
phosphoglyceromutase 4.6
tetanus neurotoxin 4.5
PIP kinase 4.5
phospholipase A1 4.5
serine acetyltransferase 4.4
arylamine N-acetyltransferase 4.4
alanyl-tRNA synthetase 4.4
carboxypeptidase Y 4.4
PRT 4.3
phosphatidylethanolamine N-methyltransferase 4.3
phosphomannomutase 4.3
isoleucyl-tRNA synthetase 4.2
triphosphatase 4.2
MsrB 4.2
ClpP 4.1
RNase P 4.1
chaperonin 4.1
nucleoside hydrolase 4.1
BAL 4.0
beta-lactamase 4.0
histidine kinase 3.9
protein farnesyltransferase 3.9
hyaluronate lyase 3.9
alanine racemase 3.8
PTPase 3.8
GMT 3.8
monoacylglycerol lipase 3.7
cholesterol acyltransferase 3.7
Lys4 3.7
lysin 3.7
restriction-modification system 3.7
anthranilate synthase 3.7
nitrile hydratase 3.7
proteinase K 3.6
beta-hydroxybutyrate dehydrogenase 3.6
thermolysin 3.6
PMT 3.5
choline kinase 3.4
venom phosphodiesterase 3.3
chymosin 3.3
transpeptidase 3.2
RNase III 3.2
ADP-ribosyltransferase 3.2
ADP-ribosyltransferase 3.1
MIP 3.1
ADPase 3.1
cathepsin D 2.9
endonuclease 2.9
cysteine synthase 2.9
CPM 2.8
enterokinase 2.8
phosphatidylinositol 4-kinase 2.7
phospholipase A2 2.7
methionine adenosyltransferase 2.7
PGM 2.7
E-2 2.7
exoribonuclease 2.6
alanine aminopeptidase 2.6
deoxyribonuclease 2.6
apyrase 2.6
MCS 2.6
prolyl endopeptidase 2.5
ubiquitin-protein ligase 2.5
acid phosphatase 2.5
PAL 2.5
aconitase 2.4
KAT 2.4
S-adenosylmethionine decarboxylase 2.4
p100 2.3
Pla 2.3
lipase 2.3
cystathionine beta-synthase 2.2
nucleotidase 2.1
farnesyltransferase 2.1
ECH 2.1
PAL 2.1
sorbitol dehydrogenase 2.1
hormone-sensitive lipase 2.1
papain 2.1
phosphodiesterase 2.0
TAT 1.9
transglutaminase 1.9
arylsulfatase 1.9
IKK 1.9
CDR 1.9
RNase 1.9
SPC 1.8
topoisomerase 1.8
neutrophil elastase 1.7
RNase 1.7
phenylalanine hydroxylase 1.7
topoisomerase 1.7
chitinase 1.7
glucokinase 1.7
NADPH oxidase 1.6
deoxyribonuclease 1.6
citrate synthase 1.6
farnesyltransferase 1.6
AST 1.6
DNase 1.6
sialyltransferase 1.6
phospholipase C 1.6
sialyltransferase 1.6
sialyltransferase 1.6
sulfatase 1.5
NADPH oxidase 1.5
leucine aminopeptidase 1.5
PRA 1.5
PTA 1.4
adenosine deaminase 1.4
adenosine deaminase 1.4
catalase 1.4
glycerol-3-phosphate dehydrogenase 1.4
glycerol-3-phosphate dehydrogenase 1.3
ATPase 1.3
elastase 1.3
more...
Compound
D-Quinovosamine 11.2
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
Dephospho-CoA 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.6
C20H30O2 10.2
C20H30O2 10.2
C20H30O2 10.2
C20H30O2 10.2
C20H30O2 10.2
C20H30O2 9.8
C20H30O2 9.8
octacosanoic acid 9.7
C20H30O2 9.6
Sandaracopimaric acid 9.3
C20H30O2 9.3
C20H30O2 9.3
triacontanoic acid 9.2
Pimaric acid 9.2
Isopimaric acid 9.0
Grepafloxacin 8.9
C15H20O3 8.8
octose 8.7
Isoborneol 8.7
C17H21NO2 8.7
Cysteine hydrochloride 8.7
Midecamycin 8.6
Midecamycin 8.6
Norethandrolone 8.5
1-heptadecene 8.2
butyl 4-hydroxybenzoate 8.2
octonic acid 8.1
octonic acid 8.1
octonic acid 8.1
octonic acid 8.1
Brolene 8.1
ABT-773 8.1
Quinupristin 8.0
ST-37 7.9
Bronopol 7.9
ACES 7.7
Globomycin 7.7
DVC 7.6
Telithromycin 7.6
Erythromycin 7.6
Trovafloxacin 7.5
Roxithromycin 7.4
Sparfloxacin 7.3
Cefozopran 7.2
Rufloxacin 7.2
Azithromycin 7.1
Kaurenoic acid 7.1
Mibolerone 7.1
Gatifloxacin 7.1
Abietic acid 7.0
Cefdinir 7.0
2-AA 6.9
3,5-diaminobenzoic acid 6.9
Clarithromycin 6.8
2,4-hexadienal 6.7
Spiramycin 6.7
Ofloxacin 6.6
Spiramycin 6.6
Rifapentine 6.5
S-15 6.5
Fleroxacin 6.4
Chondroitin sulfate A 6.3
TBO 6.3
phenylarsonic acid 6.3
Josamycin 6.3
Josamycin 6.3
Josamycin 6.2
Sitafloxacin 6.2
Cefonicid 6.2
Flucloxacillin 6.2
Estate 6.0
meso-diaminopimelate 6.0
Levofloxacin 5.9
Ferric citrate 5.9
FK520 5.8
Tiamulin 5.8
Moxifloxacin 5.7
2,2,2-trichloroethanol 5.6
Noscapine 5.6
Rifampicin 5.6
2-methylbutanal 5.6
Clavulanic acid 5.6
Natamycin 5.5
chlorine 5.5
Dianabol 5.5
heptose 5.5
heptose 5.5
heptose 5.5
thioglycollate 5.4
Virginiamycin 5.4
hippurate 5.3
Chlorite 5.3
Tazobactam 5.2
Deoxyribonucleic acid 5.2
3-hydroxy-2-butanone 5.2
sedoheptulose 7-phosphate 5.1
TRU 5.1
Tigecycline 5.1
9,10-dihydroanthracene 5.0
Cefoxitin 5.0
2-ethyl-1-hexanol 5.0
1,2-dichloroethylene 5.0
2-Deoxy-D-glucose 5.0
Clindamycin 5.0
Lomefloxacin 5.0
1,2-dichloroethylene 5.0
2-furoic acid 4.9
Chlortetracycline 4.9
Cefuroxime 4.9
BAA 4.9
Surfactin 4.9
Imipenem 4.9
SVC 4.9
sulfamide 4.9
sulfamide 4.9
Amoxicillin 4.9
2-ethyl-1-hexanol 4.9
Ciprofloxacin 4.9
2-furoic acid 4.8
MBC 4.8
FK506 4.8
azepane 4.8
ELA 4.8
Cefpirome 4.8
DPA 4.8
ELA 4.8
more...