Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023241 (
Legionella
)
6,990
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently,
Legionella
pneumophila
effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of
mitochondrial carrier
proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.
...
PMID:The
Legionella pneumophila
effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases. 2896 93
