Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023241 (Legionella)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The enzyme activities of four strains of Legionella pneumophilia were investigated by using the API ZYM system (API System S.A., F-38390 Montalieu Vercieu, France) and synthetic substrates. Aminopeptidases were detected specifically against L-alanine, L-arginine, L-aspartic acid, L-cystine, L-glutaminic acid, glycine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-tryptophan, L-tyrosine, and L-valine. Furthermore, the bacteria possesses esterase activity splitting propionate, butyrate, caproate, caprylate, and caprate, but not laurate, myristate, palmitate, and stearate, esters. The enzymes studies were inhibited partially by aprotinin. No inhibition of phosphatase (pH range, 5.4 to 8.5) or of phosphoamidase was observed. Activities of arylsulfatase, chymotrypsin, trypsin, and glycosidases could not be detected.
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PMID:Enzymatic profile of Legionella pneumophilia. 616 35

Concentrated extracellular supernatants from Legionella pneumophila, L. bozemanii, L. dumoffi, L. gormanii, but not L. micdadei, exhibited a strong chymotrypsin-like activity upon synthetic chromogenic tri- and tetrapeptides. Bacterial cell sonic extracts showed low protease activities, different from those of the extracellular concentrates. Extracellular concentrates were also tested in the API ZYM system, where weak protease activity only was recorded. Protease inhibitors decreased the activity of the extracellular Legionella proteases upon the chromogenic peptides.
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PMID:Demonstration of extracellular chymotrypsin-like activity from various Legionella species. 675 85

The API ZYM system was used to investigate enzymatic activities of Legionella pneumophila and other Legionella-like organisms. Leucine aminopeptidase, alkaline and acid phosphatase, butyrate and caprylate esterase, and phosphoamidase activities were consistently detected in all strains tested. No evidence of myristate lipase, trypsin, chymotrypsin, or glycosidase activity was found.
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PMID:Enzymatic activities of Legionella pneumophila and Legionella-like organisms. 718 5