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Query: UMLS:C0023241 (Legionella)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

9 consecutive cases of Legionnaires' disease are presented, all of which involved either a pathological urinary sediment or acute renal insufficiency. Diabetic glomerular sclerosis and terminal septic shock in one patient accounted per se for the urinary findings and terminal oliguric renal failure. In the remaining 8 patients the renal abnormalities are interpreted as manifestations of Legionnaires' disease: these were acute renal insufficiency in 6, requiring dialysis treatment in 4, proteinuria in 7, hematuria in 5, leukocyturia in 5 and cylindruria in 3 patients. One patient died of pneumonia and one patient, without Legionella-related renal involvement, of septic shock. Renal histology of 5 patients showed acute interstitial nephritis in one and diffuse sclerosing interstitial nephritis in a second patient, whose biopsy was obtained after 3 months' hemodialysis treatment. In 3 patients renal biopsy findings were explained by preexisting renal pathology, i.e. diabetic nephropathy, chronic transplant rejection and shock kidney respectively. Renal failure requiring hemodialysis and urinary abnormalities were largely reversible.
Schweiz Med Wochenschr 1986 Dec 06
PMID:[Renal involvement in Legionnaires' disease]. 381 99

IgG and IgM antibodies anti-Legionella pneumophila group 1 were detected by fluorescent-antibody technique according to Wilkinson et al. (1979) in the sera of 101 patients with pneumonia. Positive sera were tested by the same authors' modified technique (1981). Our results indicate a low specificity of the first method, since 43.7% of the IgG-positive sera and all the IgM-positive sera were negative when tested by the modified method. 8.9% of the sera were IgG-positive, confirming the relatively high diffusion of the microorganism. In none of the studied patients an increase on antibody titer or an IgM-positivity were observed; in none of the studied cases of pneumonia the aetiological agent was therefore Legionella pneumophila.
Quad Sclavo Diagn 1985 Dec
PMID:[Research on IgG and IgM anti-Legionella pneumophila group 1 in 101 subjects with pneumonitis]. 383 16

This study was undertaken to determine the frequency of Legionella infection in a dental clinic setting. Serum samples from 270 dental clinic personnel were evaluated using an enzyme-linked immunosorbent assay to detect Legionella-specific IgM and IgG antibodies. The pooled-species whole-cell-antigen preparation used in these assays was derived from six Legionella pneumophila strains and one strain each from Legionella bozemanii and Legionella micdadei. Significant levels of IgG and IgM antibodies were found in 20% and 16%, respectively, of the samples. This compares with 8% and 10%, respectively, for a randomly selected non-clinical group from the region (P less than 0.005). Samples from clinic personnel with significant IgG titers (greater than 1:128) were also evaluated for activity to each of the eight single-species antigens, with the following results: L. pneumophila, 45% (combined six strains); L. micdadei, 37%; and L. bozemanii, 18%. Comparing individuals' "years spent in the clinic environment" with the incidence of significant antibody levels strongly suggests that the risk of Legionella infection increases proportionately with increased clinic exposure time (P less than 0.05). Analysis of these data implies that Legionella may be present in the dental clinic environment, thus creating an increased risk for clinical personnel or patients.
J Dent Res 1985 Dec
PMID:Prevalence of Legionella-specific IgG and IgM antibody in a dental clinic population. 386 49

A prospective study of nosocomial pneumonia following major head and neck surgery was conducted when it was recognized that Legionella contaminated the hospital water supply. Legionella pneumonia had not previously been diagnosed in our hospital. Every head and neck patient with nosocomial pneumonia had specialized tests performed. During the 18-month study period, 29% of patients with nosocomial pneumonia (7 of 27) had evidence of legionellosis. The sero-group of the infecting Legionella was the same as the Legionella in the water supply. Legionella was seen exclusively in patients with clinically evident aspiration. Legionella pneumonia was not demonstrated in patients undergoing laryngectomy. We conclude that specialized testing must be employed to avoid delay in diagnosis and failure to administer specific antibiotic therapy. Legionellosis may be underdiagnosed in hospitalized patients.
Laryngoscope 1985 Dec
PMID:Nosocomial Legionella pneumonia in a population of head and neck cancer patients. 390 25

Simultaneous experiments were performed with sterilized and non-sterile water and an artificial hard water. After seeding with an environmental isolate of Legionella pneumophila numbers in the sterile and hard water decreased rapidly and colonization of various tap washer fittings failed to take place. Adhesion and growth of an environmental isolate of L. pneumophila to washers in non-sterile tap water was followed over a 4-month period with fluorescein-labelled antibody and by scanning electron microscopy. After adherence the individual cells appeared to divide to form chains which spread over the surfaces. Organisms other than legionellas were also present and a complex colonization matt was formed which was embedded in a protective coat of slime and debris. The numbers of L. pneumophila recovered from the water were highest between 4 and 7 weeks but they could still be cultivated after 4 months.
J Appl Bacteriol 1985 Dec
PMID:The persistence of Legionella pneumophila in non-sterile, sterile and artificial hard waters and their growth pattern on tap washer fittings. 391 60

Legionella maceachernii, previously isolated only from the environment, was shown to be a cause of fatal pneumonia in an immunocompromised patient.
J Clin Microbiol 1985 Dec
PMID:Fatal Legionella maceachernii pneumonia. 406 17

A 2 yo male child ingested approximately 15 ml of a Gun Blue solution containing selenious acid, nitric acid and copper nitrate. He was immediately given milk and vomited spontaneously blood-stained food with a garlic smell. He was admitted to our Centre less than 3 hr following ingestion. An esophago-gastroscopy showed a second degree burn of both esophagus and stomach. He became comatose and had to be ventilated mechanically. Metabolic acidosis, leucocytosis, hyperglycemia and hemoconcentration were also observed. During the following day he developed a severe intestinal distension, a cardiomyopathy (CPK = 1,302, cardiac arrhythmia), and moderate hepatic, renal and pulmonary dysfunctions. Plasma selenium concentration was 285 micrograms/L and the maximum urinary concentration was 28,459 micrograms/L. After 4 days, his condition had improved considerably and he was about to be extubated when he suddenly developed acute respiratory distress. A similar episode occurred 24 hr later. His lung function progressively deteriorated; later he required the use of an extracorporeal membrane lung. Legionella dumofii was found the causative agent. He died 17 d after ingestion despite aggressive treatment. Acute selenious acid poisoning and its relation to Legionnaire's disease is discussed.
Vet Hum Toxicol 1985 Dec
PMID:Acute poisoning by selenious acid. 408 70

Mild diarrhea of poorly documented volume is common early in the course of Legionella infection. We report massive diarrhea of 1.8 to 3 liters per day in a patient with pneumonia in whom Legionella micdadei was isolated from pleural fluid and infection was confirmed serologically. The large volume of diarrhea, not previously associated with Legionella infection, remained unexplained despite clinical evaluation and postmortem study of the gastrointestinal tract. This case expands the clinical spectrum of Legionnaires' disease to include massive diarrhea, which in our patient constituted the chief complaint.
J Clin Gastroenterol 1985 Dec
PMID:Massive diarrhea in Legionella micdadei pneumonitis. 408 49

Twenty-one strains of Legionella pneumophila, representing the six known serotypes of the organism, cultured on various bacteriological media and in the yolk sacs of fertile hens' eggs were examined by negative stain electron microscopy for flagella and pili. These appendages were usually observed after cultivation on media capable of inducing an early profuse growth of the organisms.
J Clin Pathol 1980 Dec
PMID:Electron microscopic evidence of flagella and pili on Legionella pneumophila. 616 Nov 38

Non-proliferating cells of Legionella show a rather small proteolytic action on human serum proteins. However, if the strains grow on agar plates containing serum the proteolysis is very strong. This effect may be due to an induction of the appropriate enzymes by their substrates. The alterations of 24 investigated proteins demonstrated by immunoelectrophoresis show anodic shifts of bands and their disappearance (Table 1, Fig. 1-15). The shifted proteins are not degraded significantly. Their altered electrophoretic mobility may be due to a change of electrical charge by loss of one or a few end standing amino acids. The disappearance of bands in the immunoelectrophoretic assay and the simultaneous diminution of the protein concentration measured by the method of immunodiffusion suggests a proteolysis (Table 2). No inhibitory effect of the proteinase inhibitor aprotinin could be observed. The results suggest that the extent of the enzyme induction may be decisive for the virulence of a strain.
Zentralbl Bakteriol Mikrobiol Hyg A 1983 Dec
PMID:Induction of proteinases in Legionella by growth on agar containing serum. 620 Oct 25


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