Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
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Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0023241 (
Legionella
)
6,990
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The adhesin
Legionella
collagen-like (Lcl) protein can bind to extracellular matrix components and mediate the binding of
Legionella
pneumophila
to host cells. In this study, electrochemical impedance spectroscopy (EIS) and surface plasmon resonance (SPR)-based biosensors were employed to characterize these interactions between glycosaminoglycans (GAGs) and the adhesin Lcl protein. Fucoidan displayed a high affinity (K
D
18 nM) for Lcl protein. Chondroitin sulfate A and dermatan sulfate differ in the position of a carboxyl group replacing D-glucuronate with D-
iduronate
. Our results indicated that the presence of D-
iduronate
in dermatan sulfate strongly hindered its interaction with Lcl. These biophysical studies provided valuable information in our understanding of adhesin-ligand interactions related to
Legionella
pneumophila
infections.
...
PMID:Biosensors for the Detection of Interaction between
Legionella pneumophila
Collagen-Like Protein and Glycosaminoglycans. 3011 Aug 99
