Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023241 (Legionella)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 38-year-old male patient who was admitted to a private hospital in Kuala Lumpur presented with fever, symptoms of respiratory infection and diarrhoea. On admission, he was febrile, toxic looking, dehydrated with hypotension and tachycardia. No clinical signs of respiratory infection were detected on admission. Initially he was treated as a case of septicaemia with fluid therapy and intravenous antibiotic (Perfloxacin). Subsequently, he was noticed to have pneumonia in the right lower zone of the lung. His sputum, stool and blood were sent for culture and the results were negative. Sputum culture for Legionella and serological tests for Mycoplasma and Legionella were also reported negative. Sandwich ELISA performed on his urine sample detected Legionella pneumophila antigen. L. pneumophila mip gene was also detected in his urine by polymerase chain reaction. The patient was commenced on Erythromycin and he responded favourably to the treatment. The present case shows that L. pneumophila should not be overlooked as one of the causative agents of pneumonia and rapid techniques of urinary antigen and DNA detection should be utilized to make an early diagnosis of the infection.
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PMID:Diagnosis of legionnaires' disease by urinary antigen and DNA detection: a case report. 1719 93

The current systematic review investigates the antibiotic susceptibility pattern of Legionella pneumophila isolates from the 1980s to the present day, deriving data from clinical and/or water samples from studies carried out all over the world. Eighty-nine papers meeting the inclusion criteria, i.e., "Legionella pneumophila" and "resistance to antibiotics", were evaluated according to pre-defined validity criteria. Sixty articles referred to clinical isolates, and 18 articles reported water-related L. pneumophila isolates, while 11 articles included both clinical and water isolates. Several methods have been proposed as suitable for the determination of MICs, such as the E-test, broth and agar dilution, and disk diffusion methods, in vivo and in vitro, using various media. The E-test method proposed by the European Society of Clinical Microbiology and Infectious Diseases (EUCAST) seems to be the second most frequently used method overall, but it is the preferred method in the most recent publications (2000-2019) for the interpretation criteria. Erythromycin has been proved to be the preference for resistance testing over the years. However, in the last 19 years, the antibiotics ciprofloxacin (CIP), erythromycin (ERM), levofloxacin (LEV) and azithromycin (AZM) were the ones that saw an increase in their use. A decrease in the sensitivity to antibiotics was identified in approximately half of the reviewed articles.
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PMID:Antibiotic Resistance of Legionella pneumophila in Clinical and Water Isolates-A Systematic Review. 3279 66


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