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Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
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Target Concepts:
Gene/Protein
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Query: UMLS:C0023241 (
Legionella
)
6,990
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Sediment and indigenous microflora taken from water distribution systems has been shown to promote the survival of
Legionella
pneumophila. The effect of sediment and indigenous microflora on Tatlockia micdadei (Pittsburgh pneumonia agent,
PPA
) was evaluated by growth curve experiments. Symbiosis between
PPA
and environmental bacteria was demonstrated by satellitism experiments. Unlike L. pneumophila, the concentration of
PPA
remained stationary in test tube suspensions containing both microflora and sediment. The difference in the ecology between the two organisms may explain the infrequent environmental recovery of
PPA
and, ultimately, the epidemiologic differences between
Legionnaires disease
and Pittsburgh pneumonia.
...
PMID:Tatlockia micdadei (Pittsburgh pneumonia agent) growth kinetics may explain its infrequent isolation from water and the low prevalence of Pittsburgh pneumonia. 401 89
Using an objective scoring system, chest radiographs were reviewed in 23 cases of pneumonia due to the Pittsburgh pneumonia agent (
PPA
, Tatlockia micdadei, Legionella micdadei), including six cases of pneumonia with simultaneous isolation of
PPA
and L pneumophila (
Legionnaires' disease
). Infiltrates were typically segmental to lobar; nodular infiltrates were noted in three cases. Spread to additional lobes after presentation occurred in four of 17
PPA
infections. Pneumonia caused by both
PPA
and L pneumophila was unusually severe, with involvement of all lobes occurring in four of six cases, compared with one of 17 cases of
PPA
infection (p less than 0.02). Radiographic severity did not correlate with underlying disease, immune status, or outcome. The majority of patients receiving erythromycin demonstrated objective radiologic improvement. In a patient population that included nonimmunosuppressed patients, nodule formation and rapid radiologic progression were not found to be characteristic of
PPA
pneumonia.
...
PMID:Pneumonia caused by Pittsburgh pneumonia agent: radiologic manifestations. 669 60
The discovery of
Legionella
pneumophila is described and the clinical and epidemiological aspects of legionellosis (
Legionnaire's disease
) are presented. "New" pneumonia agents discovered after isolation and description of
Legionella
pneumophila, and which as yet lack definite designations, are mentioned. Up to June 1980, two additional bacilli not identical with
Legionella
pneumophila have been described and variously named, i.e. 1. WIGA (probably identical with ALLO), 2. TATLOCK (probably identical with HEBA and
PPA
). A third potential "new" pneumonia agent, named TEX-LK, must be added although it has been isolated in only one case of pneumonia.
...
PMID:[Discovery of Legionella pneumophila: achievement in modern bacteriology]. 720 62
