Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023241 (Legionella)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Quinupristin/dalfopristin (RP 59500, Synercid) is a parenteral streptogramin combination antimicrobial that possesses a synergistic and often bactericidal action against many Grampositive species. In this study, a collection of 1270 uncommonly isolated or tested strains were evaluated for susceptibility to quinupristin/dalfopristin using agar dilution minimum inhibitory concentration (MIC) methods described in the National Committe for Clinical Laboratory Standards. The greatest antimicrobial activity observed for quinupristin/dalfopristin was against staphylococci, streptococci, the pathogenic neisseria, Legionella spp., Lactobacillus spp., and Peptostreptococcus spp. (MIC90 range, 0.5-2 micrograms/ml). Marginal activity (MIC90s, 4 to 8 micrograms/ml) was identified for the rarer enterococci, Leuconostoc spp., Pediococcus spp., and Streptococcus bovis. Against Haemophilus parainfluenzae, Bacteroides thetaiotaomicron, Fusobacterium spp., and Prevotella spp., the streptogramin was inactive. Although no susceptible breakpoint has been approved for quinupristin/dalfopristin, three possible breakpoints (< or = 1, < or = 2, or < or = 4 micrograms/mL) were evaluated. Acceptance of the lower breakpoints (< or = 1 or < or = 2 micrograms/mL) would limit quinupristin/dalfopristin use to staphylococci, streptococci, gonococci, meningococci, and Legionella spp. These results markedly expand the understanding of the usable spectrum of quinupristin/dalfopristin.
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PMID:In vitro activity of quinupristin/dalfopristin (RP 59500) against a large collection of infrequently isolated or tested species. 890 12

The activities of quinupristin/dalfopristin (Synercid), erythromycin and azithromycin against 22 Legionella spp. isolates were measured by a microbroth dilution method. The MICs that inhibited 90% of strains tested were 0.5, 0.35, and 0.5 microg/mL for quinupristin/dalfopristin, erythromycin, and azithromycin, respectively. Quinupristin/dalfopristin was only partially active against intracellular L. pneumophila at high (2 microg/mL), but not low (1 microg/mL) concentration. Activity of the drug in a guinea pig model of Legionnaires' disease could not be accurately determined because of drug toxicity for the guinea pig, although there was evidence that the drug has in vivo activity.
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PMID:In vitro activity of quinupristin/dalfopristin (Synercid, RP 59500) against Legionella spp. 1074 67