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Query: UMLS:C0023241 (Legionella)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied, in a prospective way, the characteristics of definitively diagnosed nosocomially acquired pneumonias in our hospital over 36 months. Out of 55 cases, 27 were due to Legionella pneumophila and 28 to other, non-Legionella bacteria. The cases of legionellosis concentrated in July, August, and December. The only risk factors that showed significant differences (p less than 0.05) were general anesthesia and surgery and immunosuppressive disease, which were more frequent in the non-Legionella group, as were chronic liver disease and lowering of consciousness level. The absence of severe underlying disease, chronic or not, was uncommon in both groups, but more frequent in the Legionella group. We observed no differences in the clinical features of the two groups. Mean values of gamma-glutamyltranspeptidase and total bilirubin were higher (p less than 0.05) in the non-Legionella group. The only x-ray data that showed significant difference were pleural effusion, more frequent in the non-Legionella group (p less than 0.02). The mortality rate of legionellosis was 14.6 percent compared to 35.7 percent for the non-Legionella group (p less than 0.05). We conclude that a sure differential diagnosis based on clinical, roentgenographic and analytical features of both groups is not possible. The relatively low mortality rate of the Legionella group, when compared to other series of nosocomial legionellosis, could be due to the standard use of erythromycin in the therapeutic approach to nosocomial-acquired pneumonia in our hospital.
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PMID:Comparative study of Legionella pneumophila and other nosocomial-acquired pneumonias. 198 93

Legionnaires' disease is an important, although often overlooked, complication in the patient postoperatively. Up to 50% of all nosocomial legionellosis in the hospitals reviewed was found in surgical patients. Patients undergoing a transplant procedure are at highest risk, but occurrence is common in the surgical patient undergoing general anesthesia, endotracheal intubation, or both. Aerosolization, aspiration, and direct instillation of contaminated water during manipulation of the respiratory tract are likely mechanisms of transmission. The usual clinical presentation is that of a nonspecific pneumonia. Specialized laboratory techniques including selective culture media, direct fluorescent antibody stains, and serological detection of antibodies are necessary for accurate diagnosis. If these tests are not routinely available, Legionnaires' disease may remain undiagnosed. Environmental surveillance of the hospital water distribution system is advisable for hospitals with a large surgical case load. If transplantation is performed, such surveillance is mandatory.
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PMID:Legionnaires' disease: an emerging surgical problem. 354 17

A case of extensive Legionella pneumonia is presented. The patient required an extended period of artificial ventilation, notably punctuated by episodes of dysrhythmia and severe haemodynamic instability, but who nevertheless eventually recovered. Intensive care aspects of Legionnaires' disease are discussed.
Anaesthesia 1986 Jun
PMID:Intensive care aspects of severe Legionella pneumonia. 372 32

The paper presents the most recent recommendations for the treatment and prevention of infective endocarditis (IE). The treatment of IE is complex and requires close collaboration among specialists in infectious diseases, cardiology, cardiac surgery and microbiology. The mainstay of medical treatment is antibiotic therapy. Theoretical considerations regarding vegetations and antibiotics have practical consequences on the route and modalities of administration of antibiotics and on the techniques used to monitor treatment. The choice of antibiotics depends on the microorganism (streptococci, enterococci, staphylococci, HACEK group [Haemophilus sp., Actinobacillus sp., Cardiobacterium sp., Eikenella sp. and Kingella sp.], Coxiella, Brucella, Legionella, Bartonella, fungi) and on whether IE occurs on native or prosthetic valves. Treatment of IE with negative blood cultures is particularly difficult. Cardiac surgery is often needed during the bacteriologically active period (in ~50% of patients). The decision to intervene and the optimal timing of the intervention requires careful consideration of multiple potential risks: the haemodynamic risk, the infectious risk, the risk due to cardiac lesions, the risk due to extracardiac complications and the risk due to the location of infective endocarditis. Even though the efficacy of antibiotic prophylaxis of IE is not completely proven, it is recommended for selected patients who undergo an at-risk procedure. Lists of cardiac conditions and of medical procedures at risk are presented; specific antibiotic prophylactic regimens for dental and upper respiratory tract procedures in out-patients, procedures under general anaesthesia and urological and GI procedures are outlined.
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PMID:Treatment and prevention of infective endocarditis. 1182 27

Early warning scoring is designed to be an objective tool to aid identification of hospital patients at risk of deterioration. 'Track and trigger' systems using such scores are widely used but many aspects of scoring have not been clarified. We aimed to document how observations and scores are used in practice as part of a typical track and trigger system. We extracted patient observations and early warning scores from the casenotes of 189 patients admitted to Furness General Hospital during a large outbreak of Legionnaires' disease in 2002. We used these 3739 sets of primary observations to recalculate scores, and compared them with those recorded in the casenotes. Recording of patient observations was variable. Early warning scores were derived from 2607 sets of observations (69.7%), of which 571 (21.9%) had been incorrectly calculated. Incorrect scoring meant that 66 of 270 patients (24.4%) whose observations should have reached the trigger value did not. Patients with more abnormal observations were more likely to be misscored. Scoring errors were more likely to lead to underscoring as the degree of physiological abnormality increased. Patients with confirmed Legionnaires' disease were more likely to be incorrectly scored. We conclude that the assignment of early warning scores is prone to error and this may delay referral of at-risk patients for critical care management.
Anaesthesia 2006 Mar
PMID:Incidence and significance of errors in a patient 'track and trigger' system during an epidemic of Legionnaires' disease: retrospective casenote analysis. 1697 42

There are few reports on general anesthesia in survivors of ARDS. Patients after recovery from ARDS are at risk for compromised pulmonary function, neuromuscular weakness and cognitive dysfunction. We report 2 cases of general anesthesia in survivors of ARDS. In Case 1, a 64-year-old man who had recovered from ARDS associated with Legionella pneumonia underwent carotid endarterectomy. In Case 2, a 69-year-old man who had recovered from ARDS associated with pneumococcal pneumonia underwent hepatectomy. Concerning the preoperative assessments, the spirometry data were almost normal but Hugh-Jones classification scale was II in both cases. Diffusion disturbance might be the cause of discrepancies between good respiratory functions and limited daily activities. In both cases, anesthesia was given with propofol, fentanyl remifentanil and sevoflurane. Peak airway pressure was maintained below 15 cmH2O with pressure control ventilation. They were extubated at the end of surgery and there were no serious complications during the perioperative period.
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PMID:[Two cases of general anesthesia after recovery from ARDS]. 2497 63