Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023241 (Legionella)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The immune response to individual major antigens of Legionella bozemanii was studied in 67 sera from 26 inpatients with febrile disease using immunoblotting techniques. All the patients had fever of unknown origin and showed strong serological reactions to L bozemanii that cross-reacted with Rickettsia typhi, as determined by a standard indirect microimmunofluorescence assay. Sera analysed by western blotting reacted with 12-14 molecular components of L bozemanii with apparent molecular weights ranging from 14,000 to 94,000 daltons. These reactions compared well with a reference system using antisera of rabbits immunised with the same strain of Legionella. The three major cross-reactive components of R typhi were polypeptide antigens of 94,000, 67,000 and 43,000 daltons. It is concluded that western blotting can help in the differential diagnosis of patients with fever of unknown origin whose sera cross-react to L bozemanii and R typhi.
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PMID:Western blot analysis of immune response to Legionella bozemanii antigens. 175 85

In a patient with fever of unknown origin and granulomas of the liver extensive serological testing revealed a significant rise in antibodies only to Legionella pneumophila despite the fact that he never was shown to have pneumonia. Absorption studies yielded additional evidence that this immunological response was specific for L. pneumophila. Bacteremia and extrapulmonary involvement, including the liver, has been shown with L. pneumophila, but never without pneumonia. Furthermore, granulomas of the liver have not been described in connection with legionellosis. This patient is regarded as a case of fever of unknown origin related to L. pneumophila infection.
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PMID:Legionnaires' disease and fever of unknown origin. 707 31

We present a patient with myalgia and ongoing fever without respiratory symptoms caused by a Legionella pneumophilia infection. We conclude that in patients with fever of unknown origin legionellosis should be considered, even in the absence of pulmonary symptoms. When considering legionellosis, diagnostic tests should include the urinary antigen test.
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PMID:Severe non-type-1 Legionella pneumophila infection without pneumonia. 2016 60