Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023241 (Legionella)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cooling towers are considered to be man-made amplifiers of Legionella spp. Thus, the proper maintenance and choice of biocides is important. The only biocidal measure that has thus far been shown to be effective in field tests is the judicious use of chlorination. Perturbation studies with 1-bromo-3-chloro-5, 5-dimethylhydantoin (Bromicide; Great Lakes Chemical Corp., West Lafayette, Ind.) (BCD) were conducted on an industrial cooling tower shown to contain Legionella pneumophila. At the concentrations recommended by the manufacturer, neither the density nor the activity of L. pneumophila was affected. At comcentrations greater than 2.0 ppm (2.0 micorgram/ml) free of residual, BCD was not effective in reducing L. pneumophila to source water concentrations, nor was it effective in reducing the 2-p-iodophenyl-3-p-nitrophenyl-5-phenyl tetrazolium chloride activity of the bacterium in situ. The data indicate that at concentrations up to 2.0 ppm, BCD is not effective in these tower studies.
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PMID:Effectiveness of 1-bromo-3-chloro-5,5-dimethylhydantoin against Legionella pneumophila in a cooling tower. 674 44

Legionella and amebae populations in 16 cooling towers were challenged with three commercially available biocide formulations. The active agents were: a chlorinated phenolic thioether (CPTE), bromo-nitro-propane-diol (BNPD), and bromo-chloro-dimethylhydantoin (BCD, in briquette form). The towers were dosed with these biocides for approximately 4 weeks. BCD was effective against Legionella in each of nine challenge experiments, and CPTE in eight of nine challenges. BNPD was effective in only five of 11 challenges. None of the biocides had any significant effect in reducing planktonic amebae concentrations during the challenges.
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PMID:Field trial of biocides for control of Legionella in cooling towers. 776 50