Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023241 (
Legionella
)
6,990
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Three extracellular proteases produced by
Legionella
pneumophila during growth in liquid medium were examined for their effects on human
alpha-1-antitrypsin
(
alpha-1-AT
). One of these proteases, tissue-destructive protease (TDP) destroyed completely the trypsin-inhibitory capacity of
alpha-1-AT
at protease: inhibitor molar ratios down to 0.002:1. After inactivation by TDP, the Mr of
alpha-1-AT
was reduced by 5000 in SDS-PAGE. This suggested that inactivation entailed only limited cleavage.
...
PMID:Inactivation of human alpha-1-antitrypsin by a tissue-destructive protease of Legionella pneumophila. 304 37
