Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023241 (Legionella)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In microbiology, the polymerase chain reaction (PCR) has become an important tool for the analysis of clinical samples. For example, it led to the detection of Hepatitis-B Virus DNA (HBV-DNA) in patients with serological patterns not previously associated with active infection (1). PCR-based assays are also more sensitive than conventional tests for the detection of many other infective agents, like Hepatitis-C Virus (HCV), herpes viruses, or Legionella pneumophila (2). In some cases, however, the detection of the nucleic-acid sequences of a certain infectious agent is not very informative. Here is a quantitative information of the amount of nucleic acid needed. DNA quantitation is useful for monitoring the viral load during antiviral therapy (3), in estimating the degree of infectiousity of individuals (4,5), and (e.g., for herpes viruses) to differentiate between latent and active infection. Owing to its sensitivity, quantitative PCR is the most sensitive technique for the quantitation of nucleic acids and therefore has been investigated in detail.
 ...
PMID:Competitive PCR quantitation utilizing a microtiter plate based format for the detection of PCR products. 2134 Aug 77

Hepatitis A, B, C, D, E, G are the most common causes of acute hepatitis, however, there are many infectious diseases affecting liver and with fever, early diagnostics of which is very important for the clinic of internal diseases. This review presents infections, causing fever and hepatitis, but not necessarily accompanied by jaundice. Leptospirosis, yellow fever have been considered, in which liver damage determines the clinic and the prognosis of the disease. In other cases, such as infectious mononucleosis, cytomegalovirus and herpetic hepatitis, typho-para-typhoid infections, typhoid, pneumonia, some viral diseases, malaria, Legionnaire's disease, hepatitis do not have their independent status and represent one of the important syndromes of a common disease. Modern methods of diagnostics and treatment of these diseases have been described.
 ...
PMID:[Acute hepatitis in infectious diseases]. 2429 83

Background. Legionella micdadei is a Gram negative bacterium that can stain weakly acid fast. It was first described in 1979 after immunosuppressed patients developed pneumonia at a Pittsburgh VA, initially given the name Pittsburgh Pneumonia Agent. It is the second most common Legionella species causing infection after pneumophila, and typically infects immunocompromised hosts. It is not easy to be cultured which makes diagnosing difficult. Case Presentation. A 31-year-old female with ulcerative colitis, primary sclerosing cholangitis, and cirrhosis presented with fever, chills, shortness of breath, dry cough, and chest pain for five days after being started on immunosuppression for autoimmune hepatitis two months earlier. The first chest CT showed small bilateral cavitary nodules. The nodules continued to grow on subsequent imaging despite what was thought to be appropriate therapy. A transthoracic biopsy was performed which grew Legionella micdadei and the patient improved after being treated with levofloxacin. Conclusion. Legionella micdadei is an atypical pathogen known to cause pneumonia in immunosuppressed patients. This case highlights a typical presentation of an atypical infection not commonly thought about and should be considered when nodules are growing despite being on broad antimicrobial therapy.
...
PMID:Legionella micdadei: A Forgotten Etiology of Growing Cavitary Nodules: A Case Report and Literature Review. 2645 Dec 67


<< Previous 1 2