Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023241 (Legionella)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We describe 3 patients with simultaneous infection by Cryptococcus neoformans and Legionella pneumophila. Legionnaires' disease (pneumonia) occurred shortly after onset of cryptococcal meningitis in a cardiac transplant patient receiving ciclosporin, a second patient with chronic lymphocytic leukemia and a third patient with Hodgkin's disease and autoimmune hemolytic anemia. Defects in cell-mediated immunity have been identified in patients with hematologic malignancies and in those who have received organ transplants. Clinical and experimental data suggest that the primary host defense mechanism against cryptococcal and Legionella infection involves cell-mediated immunity. Thus, the simultaneous occurrence of cryptococcal and L. pneumophila infection in these 3 patients supports experimental studies which have demonstrated common host defense mechanisms against both pathogens.
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PMID:Simultaneous infection with Cryptococcus neoformans and Legionella pneumophila. In vivo expression of common defects in cell-mediated immunity. 329 33

A 65-year-old woman presented with an autoimmune hemolytic anemia and was subsequently diagnosed as having malignant lymphoma. Cytotoxic chemotherapy was followed by the development of fatal Legionnaires' disease, confirmed by isolation of L. pneumophila serogroup 6 from pleural and lung aspirate specimens. This is believed to be the first reported isolation of serogroup 6 L. pneumophila in Australia.
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PMID:A fatal case of Legionnaires' disease in an immunocompromised patient. 659 9

Chlamydia pneumoniae has often been implicated in respiratory tract infections concomitant with other pathogens. Although this agent has also been associated with other nonrespiratory diseases, to our knowledge it has never been described with autoimmune hemolytic anemia. We present a case of pneumonia in which C. pneumoniae was found in association with another important respiratory pathogen, Legionella, and with hemolytic autoimmune IgG to warm antibodies, an entity that has not been reported previously with this or any other germ of the genus Chlamydia.
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PMID:[Chlamydia pneumoniae infection associated with autoimmune hemolytic anemia due to warm antibodies]. 869 50

Legionella pneumophilia is a multi-systemic disease primarily affecting the pulmonary, gastrointestinal, and to a lesser extent, renal systems. We present a case of Legionella pneumonia, which after resolution of respiratory compromise, was complicated by the development of autoimmune hemolytic anemia (AIHA) as determined by a positive Coombs test, and negative workup of other causes. Steroid immunosuppression was initiated, and red cell counts subsequently improved. While AIHA has only been anecdotally described in one prior case, the separation in time of the development and resolution of respiratory symptoms with the development of anemia most likely makes this an under-appreciated entity. An in vitro mechanism has been suggested; however in vivo causation has yet to be proven. Given the prolonged deleterious clinical consequences associated with the development of AIHA and the increase in recognition of Legionella outbreaks, greater recognition of this potential complication and research into the pathophysiology is warranted for the future.
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PMID:Legionella-Induced Autoimmune Hemolytic Anemia: A Delayed and Unexpected Complication. 3230 Apr 42