Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023241 (Legionella)
 6,990 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Most hospitals have yet to record a case of nosocomial legionnaires' disease; the importance of isolation of Legionella pneumophila in the water system of such an institution is unclear. We undertook a prospective pneumonia study in tandem at a veterans hospital where legionnaires' disease was known to be endemic and a community teaching hospital where legionnaires' disease had never been documented. Legionella serological tests were performed on all patients with pneumonia; selective culture media and direct fluorescent antibody testing for Legionella were made readily available. Simultaneous environmental surveys for Legionella were performed. At the community hospital, we discovered that 64% of sites in the water distribution system yielded L pneumophila and that 14.3% of nosocomial pneumonias were legionnaires' disease. The epidemiologic implications of these findings are discussed. Options concerning case detection and eradication measures in the face of hospital water contamination with L pneumophila are presented.
JAMA 1983 Jun 17
PMID:Nosocomial Legionnaires' disease uncovered in a prospective pneumonia study. 685 47

Lungs from 224 patients, obtained at autopsy, were examined for Legionella pneumophila by fluorescent antibody (FA) staining. Of 121 patients who died with pneumonia, L pneumophila was present in eight cases (6.6%). (Two of the eight patients exhibited no important respiratory symptoms or fever, although pneumonia contributed considerably to their deaths. Preexisting underlying disease was present in all cases. Legionnaires' disease (LD), endemic in the central Ohio area, may cause up to 3.6% of the nosocomial pneumonias at the study site. Application of the local incidence of LD to the number of annual adult deaths in the United States indicates that many LD-associated deaths may occur each year. The study shows the importance of using the FA and Dieterle stains during routine pathological examination of lung tissue, especially from compromised hosts in endemic areas.
JAMA 1980 Jun 13
PMID:Unrecognized Legionnaires' disease as a cause of fatal illness. 699 37

Between June 18 and July 9, 1979, Legionnaires' disease (LD) developed in 13 persons who had visited a hotel complex in Wisconsin. All had visited the part of the hotel that contains the restaurants and meeting rooms (building A). Legionnaires' disease occurred in 1% who had been exclusively in the meeting rooms and in 0.1% who had eaten only at the hotel restaurants. Furthermore, 1.5% exposed to meeting room 1 and none of those exposed only to the other meeting rooms had LD. Legionella pneumophila was isolated from water in the cooling tower on top of building A. Located within 5 m downwind of the cooling-tower exhaust, a chimney with an open damper allowed cooling-tower exhaust (as demonstrated by air tracer studies) to enter meeting room 1 via the fireplace. Although cases did not occur after the cooling-tower water was treated by continuous hyperchlorination and the chimney was sealed, a seven-day lag occurred between treatment and elimination of the organism from the tower water.
JAMA 1981 Jun 19
PMID:Epidemic Legionnaires' disease. Airborne transmission down a chimney. 723 Apr 70

We reviewed chest roentgenograms from 17 persons with confirmed Legionnaires' disease. None of the cases was associated with known outbreaks. Pulmonary infiltrates, usually extensive, were present in all cases. The predominant radiological pattern of both on initial roentgenograms and those from the peak of illness was distal air space disease, usually in a segmental or lobar distribution. The lower lobes were involved most frequently. Pleural effusion and volume loss were infrequent. Radiological findings progressed rapidly and often cleared rapidly, although slow clearing was also seen in some cases. Legionnaires' disease should be included in the radiological differential diagnosis of segmental or lobar pneumonia.
JAMA 1981 Feb 13
PMID:The chest roentgenogram in sporadic cases of Legionnaires' disease. 745 87


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