Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022716 (Menkes)
 1,057 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ATP7A 260
ATPase 209
MNK 155
Wilson disease 140
X-linked 106
ceruloplasmin 92
ATP7B 86
X-linked recessive 86
Mol 86
Sep 68
MC1 62
metallothionein 53
ATP 45
eIF4E 30
MNK1 25
lysyl oxidase 24
cytochrome c oxidase 24
collagen 23
superoxide dismutase 23
ATP7A protein 21
MAPK 21
ATOX1 18
WND 17
prion 17
axonal 17
MRI 15
GNE 13
p38 13
MNK2 13
X-chromosome 12
NMR 12
elastin 12
endoplasmic reticulum 12
mTOR 11
polypeptide 11
tyrosinase 11
amyloid precursor protein 10
gut 10
ERK 9
PGK1 8
eukaryotic translation initiation factor 4E 8
membrane protein 7
CCS 7
membrane-bound 7
Met 7
ferroxidase 7
hemochromatosis 6
Ceruloplasmin 6
adaptor protein 6
AKT 6
Metallothionein 6
dopamine beta-hydroxylase 6
fur 6
SOD1 6
albumin 6
UTR 5
SGC 5
fused 5
COMMD1 5
AED 5
MIM 5
insulin 5
divalent metal transporter 1 5
Cytochrome c 5
cytochrome c 5
transferrin receptor 5
MAP kinase 4
copper transport protein 4
PI3K 4
AGS 4
caspase-3 4
eukaryotic translation initiation factor 4
GTPase 4
p53 4
SOD 4
lymphoid 4
copper transporter 1 4
olfactory 4
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 4
catenin 4
more...
Disease
Menkes 1057
Wilson's disease 80
Alzheimer's disease 47
cancer 42
tumor 24
disorders of copper metabolism 23
neuropathy 21
mental retardation 17
mental retardation 17
amyotrophic lateral sclerosis 16
brain atrophy 16
cutis laxa 15
Ehlers-Danlos syndrome 15
epilepsy 15
anemia 14
iron deficiency 14
genetic disorder 14
Parkinson's disease 13
failure to thrive 13
Copper deficiency 12
myopathy 12
developmental delay 11
malnutrition 10
acrodermatitis enteropathica 9
encephalopathy 9
breast cancer 8
tumorigenesis 8
malabsorption 8
neurological disease 8
cirrhosis 8
metabolic disorder 7
muscular atrophy 7
hemochromatosis 7
carcinoma 7
prostate cancer 7
gastric cancer 7
glioma 6
tumor growth 6
dysplasia 6
cerebral degeneration 6
fits 6
osteogenesis imperfecta 6
adenocarcinoma 6
Evans 6
trichorrhexis 6
Huntington's disease 6
Syndrome 6
acute myeloid leukemia 5
hepatocellular carcinoma 5
diabetes 5
Leigh syndrome 5
gastroesophageal reflux disease 5
Marfan syndrome 5
connective tissue disease 5
OHS 5
Pili torti 4
neuroblastoma 4
West 4
glioblastoma 4
AGS 4
incontinentia pigmenti 4
tumor progression 4
hemiplegic migraine 4
Hermansky-Pudlak syndrome 4
osteoporosis 4
ICC 4
SMAX3 4
severe mental retardation 4
heart disease 4
dementia 4
hypertension 4
profound mental retardation 4
ichthyosis 4
macrocephaly 4
leukemia 4
neurofibromatosis type 1 3
cornea 3
chondrodysplasia 3
Netherton syndrome 3
hygroma 3
more...
Symptom
seizures 54
hypotonia 25
ataxia 14
dystonia 12
dysarthria 8
hypothermia 8
tremor 6
anesthesia 4
pain 4
emaciation 4
myoclonus 3
cerebellar ataxia 3
ophthalmoplegia 2
spasticity 2
diarrhea 2
weakness 2
lethargy 2
Blotchy 1
Kayser-Fleischer ring 1
tonic seizure 1
clumsiness 1
cough 1
starvation 1
dyspnea 1
hepatomegaly 1
athetosis 1
paraparesis 1
paresis 1
splenomegaly 1
headache 1
Neuropathic pain 1
vomiting 1
blepharospasm 1
partial seizure 1
Drug
Dermatol 19
lysine 5
MAP 3
NADH 3
ascorbate 3
Asn 3
CPT-11 2
Nephron 2
IL-2 2
CSF 2
ADR 1
Leucovorin 1
Nephron 1
Leaf 1
Orphan 1
Cardiovasc 1
Retinoic acid 1
Albumin 1
pyridoxal phosphate 1
HCH 1
ABC 1
vitamin E 1
Satraplatin 1
Dakar 1
Arsenic trioxide 1
Zinc acetate 1
Enzyme
ATPase 212
ceruloplasmin 98
mitogen-activated protein kinase 34
superoxide dismutase 25
lysyl oxidase 22
cytochrome oxidase 21
tyrosinase 11
ERK 11
CCS 7
dopamine beta-hydroxylase 5
PAM 5
protein kinase 4
luciferase 4
monoamine oxidase 4
RNA polymerase 4
complex I 4
catalase 4
N-acetylmannosamine kinase 3
MAP 3
transcriptase 3
heme oxygenase 3
diaphorase 3
caspase-3 3
MEK 3
CNPase 2
AtHMA4 2
focal adhesion kinase 2
succinate dehydrogenase 2
aspartate aminotransferase 2
ACS 2
CPR 2
proteasome 2
phosphoglycerate kinase 2
prolyl hydroxylase 2
tyrosine hydroxylase 2
UDP-N-acetylglucosamine 2-epimerase 2
diamine oxidase 2
PGM 2
type III procollagen 2
phospholipase A2 1
hexokinase 1
MMP 1
NADH dehydrogenase 1
topoisomerase 1
gamma-glutamylcysteine synthetase 1
ascorbate oxidase 1
ribonuclease 1
N-acetylglucosamine 2-epimerase 1
PAH 1
N-acetylglucosamine kinase 1
RNase 1
glutathione reductase 1
Thy1 1
glutathione peroxidase 1
ribonuclease 1
sulfite oxidase 1
MEKK1 1
GSK 1
sulfite oxidase 1
RNase 1
sulfhydryl oxidase 1
phenol oxidase 1
Mg2+-ATPase 1
AMP-activated protein kinase 1
transaldolase 1
lysozyme 1
collagenase 1
topoisomerase 1
calcium pump 1
dihydropyrimidine dehydrogenase 1
chalcone synthase 1
ECH 1
uricase 1
lysyl hydroxylase 1
creatine kinase 1
plasmin 1
prostate-specific antigen 1
phosphodiesterase 1
lipoprotein lipase 1
acid phosphatase 1
more...
Compound
copper 778
Dec 68
DNA 65
zinc 64
His 61
Clin 60
iron 55
ATP 45
cadmium 25
cysteine 21
oxygen 19
serine 18
water 14
silver 14
calcium 13
leucine 12
acetate 11
Cu(II) 10
methionine 9
threonine 9
sodium 9
lysine 7
sulfate 7
alanine 7
arginine 7
manganese 7
CCS 7
selenium 6
nickel 6
mercury 6
cobalt 6
N-acetylmannosamine 5
Arsenate 5
Cytochrome c 5
Lead 5
UDP-GlcNAc 5
valine 5
phosphate 4
MTT 4
Gly 4
Neuronal 4
glucose 4
tyrosine 4
hydrogen 4
uridine 4
Serine 4
noradrenaline 4
urea 3
proline 3
pyrimidine 3
tryptophan 3
GSH 3
DEAE 3
ammonium 3
MDA 3
MAP 3
Parenteral 3
nitric oxide 3
Guo 3
iodine 3
H2O2 3
GlcNAc 3
NH2 3
formaldehyde 3
tryptophan 3
EDTA 3
Ile 3
salt 3
NADH 3
tryptophan 3
glutamate 3
NMDA 3
formaldehyde 3
tryptophan 3
pyrimidine 3
GSH 3
Asp 2
cyanide 2
THP 2
DTT 2
more...