Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022716 (Menkes)
 1,057 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ATP7A 260
ATPase 209
MNK 155
Wilson disease 140
X-linked 106
ceruloplasmin 92
X-linked recessive 86
ATP7B 86
Mol 86
Sep 68
MC1 62
metallothionein 53
ATP 45
eIF4E 30
MNK1 25
cytochrome c oxidase 24
lysyl oxidase 24
collagen 23
superoxide dismutase 23
ATP7A protein 21
MAPK 21
ATOX1 18
prion 17
axonal 17
WND 17
MRI 15
GNE 13
p38 13
MNK2 13
endoplasmic reticulum 12
elastin 12
NMR 12
X-chromosome 12
mTOR 11
polypeptide 11
tyrosinase 11
gut 10
amyloid precursor protein 10
ERK 9
PGK1 8
eukaryotic translation initiation factor 4E 8
membrane protein 7
Met 7
membrane-bound 7
ferroxidase 7
CCS 7
Metallothionein 6
adaptor protein 6
fur 6
Ceruloplasmin 6
AKT 6
SOD1 6
dopamine beta-hydroxylase 6
hemochromatosis 6
albumin 6
fused 5
UTR 5
cytochrome c 5
AED 5
Cytochrome c 5
COMMD1 5
insulin 5
transferrin receptor 5
SGC 5
MIM 5
divalent metal transporter 1 5
UDP-GlcNAc 4
cytochrome 4
ERK1 4
MAP kinase 4
beta-actin 4
c-myc 4
caspase-3 4
eukaryotic translation initiation factor 4
AGS 4
Bcl-2 4
lymphoid 4
cyclin D1 4
ubiquitin 4
IP1 4
copper transporter 1 4
olfactory 4
peptidylglycine alpha-amidating monooxygenase 4
GTPase 4
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 4
Hermansky-Pudlak syndrome 4
SOD 4
catenin 4
p53 4
PI3K 4
copper transport protein 4
4E-BP1 3
AP-1 3
MT-2 3
VCP 3
MAP 3
p97 3
hephaestin 3
Mnk1 3
precursor protein 3
IBM2 3
pseudogene 3
Cu/Zn superoxide dismutase 3
oxidoreductase 3
mitogen-activated protein 3
pseudoxanthoma elasticum 3
MDM 3
NADH 3
UDP-N-acetylglucosamine 2-epimerase 3
transferrin 3
SOD3 3
AP19 3
E-cadherin 3
reductase 3
NMDA receptor 3
CTR1 3
adenosine triphosphatase 3
dynamin 3
HGC 3
catalase 3
threonine 3
GSH 3
phosphatase 3
prion protein 3
4EBP1 3
ferredoxin 2
ferritin 2
E1 alpha 2
MURR1 2
THC 2
Glutaredoxin-1 2
proinsulin 2
alternatively spliced 2
neurofibromatosis 2
MEK 2
tumor necrosis factor 2
translation initiation factor 2
THP 2
N-cadherin 2
IL-6 2
crinkled 2
VEGF 2
clusterin 2
XNP 2
GRP78 2
lipopolysaccharide 2
pyrroline-5-carboxylate synthetase 2
COG7 2
MT1 2
IL-2 2
CSF 2
SCO1 2
anti-apoptotic protein 2
p11 2
LEC 2
EPR 2
CBP80 2
COX17 2
transmembrane protein 2
aspartate aminotransferase 2
IFN 2
SDS 2
35 kDa 2
BRAF 2
serum albumin 2
duodenal cytochrome b 2
pituitary adenylate cyclase-activating polypeptide 2
Rho 2
She 2
extracellular superoxide dismutase 2
Werner syndrome 2
Mcl-1 2
glycoprotein 2
ferroportin 1 2
S6K1 2
vascular endothelium 2
Elastin 2
CNPase 2
hSVCT1 2
Mnk2 2
MRS 2
MK2 2
heme oxygenase-1 2
trichothiodystrophy 2
glucose transporter 2
SCO2 2
interacting protein 2
brain) 2
CD4 2
ADP 2
MELAS 2
proteasome 2
MT-1 2
serine/threonine kinase 2
Ca2+-ATPase 2
IRE 2
APP 2
RAF 2
RhoA 2
CA1 2
Ku80 2
yeast homolog 2
nuclear protein 2
CD8 2
ICP 2
ACS 2
Myc protein 2
N-acetylmannosamine kinase 2
GLUT1 2
calcium pump 2
CPX 2
cytokine 2
SLC16A2 2
X-linked inhibitor of apoptosis protein 2
neurofibromatosis type 1 2
Phosphoglycerate mutase 2
Copper-transporting ATPase 1
SNX27 1
cofilin 1
LPIN1 1
ST8SIA2 1
RGM 1
SHOC2 1
myogenin 1
lymphotoxin 1
MGC 1
alpha-amidating monooxygenase 1
disulfide isomerase 1
Cyclin D1 1
AR protein 1
EDS VI 1
ATP6V0A2 1
repressor protein 1
p21 1
JNK 1
Ah receptor 1
ST8SIA4 1
brush border 1
lipocalin-interacting membrane receptor 1
CCR6 1
NADH-ubiquinone reductase 1
MBD2 1
Androgen receptor 1
EZH2 1
AT-1 1
CRB 1
PRK2 1
c-kit 1
AP1B1 1
long chain 1
RANK 1
vimentin 1
IL-22 1
GSK 1
CCR7 1
cyclin E 1
UCHL1 1
PTEN 1
ZAP-70 1
ALD 1
hormone-sensitive lipase 1
fibrillin 1
CMP-sialic acid transporter 1
haptoglobin 1
CD127 1
prune 1
synuclein 1
p24 antigen 1
sterolin 1
scratch 1
amine oxidase 1
Pseudomonas 1
phosphodiesterase 1
Raf-1 1
matrix metalloproteinase 1
chloride channel 1
ATP1A3 1
Pol 1
epidermal growth factor receptor 1
dihydropyrimidine dehydrogenase 1
IRS 1
monocyte chemoattractant protein-1 1
BCS 1
erythropoietin 1
androgen receptor 1
IGF2AS 1
EGFR 1
CMP 1
RAR 1
PSEN1 1
CDF 1
NPC1 1
ATPase mRNA 1
RAD54 1
glutathione S-transferase 1
Kufor-Rakeb syndrome 1
apolipoprotein B 1
Bax protein 1
BiP 1
RIG-I 1
p27 1
white cell 1
hCTR2 1
EAC 1
fibrillin-2 1
Barth syndrome 1
Dictyostelium 1
hereditary hemochromatosis 1
RET 1
methyltransferase 1
mannose-6-phosphate receptor 1
SP1 1
mouse) 1
olfactory receptor 1
TRP1 1
BMP9 1
alcohol dehydrogenase 1
ASC 1
synaptophysin 1
AP-2 1
more...
Disease
Menkes 1057
Wilson's disease 80
Alzheimer's disease 47
cancer 42
tumor 24
disorders of copper metabolism 23
neuropathy 21
mental retardation 17
mental retardation 17
amyotrophic lateral sclerosis 16
brain atrophy 16
cutis laxa 15
Ehlers-Danlos syndrome 15
epilepsy 15
anemia 14
iron deficiency 14
genetic disorder 14
Parkinson's disease 13
failure to thrive 13
myopathy 12
Copper deficiency 12
developmental delay 11
malnutrition 10
acrodermatitis enteropathica 9
encephalopathy 9
malabsorption 8
breast cancer 8
tumorigenesis 8
cirrhosis 8
neurological disease 8
muscular atrophy 7
hemochromatosis 7
carcinoma 7
prostate cancer 7
gastric cancer 7
metabolic disorder 7
Evans 6
trichorrhexis 6
Huntington's disease 6
adenocarcinoma 6
cerebral degeneration 6
fits 6
glioma 6
Syndrome 6
tumor growth 6
dysplasia 6
osteogenesis imperfecta 6
Marfan syndrome 5
connective tissue disease 5
hepatocellular carcinoma 5
Leigh syndrome 5
gastroesophageal reflux disease 5
diabetes 5
acute myeloid leukemia 5
OHS 5
heart disease 4
glioblastoma 4
Hermansky-Pudlak syndrome 4
dementia 4
tumor progression 4
hemiplegic migraine 4
Pili torti 4
leukemia 4
incontinentia pigmenti 4
osteoporosis 4
AGS 4
West 4
hypertension 4
macrocephaly 4
severe mental retardation 4
ICC 4
SMAX3 4
neuroblastoma 4
profound mental retardation 4
ichthyosis 4
abortion 3
child abuse 3
chondrodysplasia 3
tuberous sclerosis 3
pseudoxanthoma elasticum 3
cornea 3
rare disease 3
melanoma 3
mitochondrial encephalomyopathy 3
optic atrophy 3
glutaric aciduria 3
MCF 3
liver disease 3
scurvy 3
urinary tract infection 3
neurofibromatosis type 1 3
QSM 3
neuronal ceroid lipofuscinosis 3
multiple myeloma 3
epidermolysis bullosa 3
GSH 3
ischemia 3
mitochondrial disease 3
Legionella 3
deafness 3
enteropathy 3
Placenta 3
Ehlers-Danlos syndrome type IX 3
Kearns-Sayre syndrome 3
Netherton syndrome 3
congenital disorder 3
ichthyosis 3
parkinsonism 3
phenylketonuria 3
Friedreich's ataxia 3
hygroma 3
chronic hepatitis 3
schizophrenia 3
homocystinuria 3
atherosclerosis 3
hydronephrosis 2
inguinal hernia 2
infectious diseases 2
respiratory failure 2
retinitis pigmentosa 2
aminoaciduria 2
cognitive impairment 2
squamous cell carcinoma 2
stroke 2
Crohn's disease 2
hemosiderosis 2
varices 2
mole 2
hereditary hemochromatosis 2
brain dysfunction 2
status epilepticus 2
Fabry 2
myocardial ischemia 2
nevoid basal cell carcinoma syndrome 2
ICP 2
SWS 2
sialic acid storage disease 2
metastases 2
virus infection 2
erythroderma 2
cold 2
ectodermal dysplasia 2
vitiligo 2
respiratory infection 2
APC 2
Waardenburg syndrome 2
Hair disease 2
Gaucher disease 2
acute lymphoblastic leukemia 2
WRN 2
cardiomyopathy 2
Charcot-Marie-Tooth disease 2
CPX 2
mole 2
Zinc deficiency 2
neuromuscular disorder 2
chronic myeloid leukemia 2
choreoathetosis 2
glucose intolerance 2
cardiovascular disease 2
GCE 2
obesity 2
angiodysplasia 2
MRS 2
iron overload 2
congestive heart failure 2
MELAS 2
Down syndrome 2
FDH 2
lymphoma 2
sideroblastic anemia 2
SDS 2
choriocarcinoma 2
B-cell lymphoma 2
Bladder diverticula 2
emphysema 2
metabolic syndrome 2
leukoencephalopathy 2
Williams syndrome 2
MELAS 2
mitochondrial myopathy 2
pheochromocytoma 2
trichothiodystrophy 2
Dermal 2
neutropenia 2
depression 2
Cerebellum 2
hepatitis 2
PBT 2
plaque 2
ALD 2
colon cancer 2
motor neuron disease 2
hernia 1
intellectual impairment 1
SCID 1
NCR 1
SEM 1
hiatal hernia 1
X-linked severe combined immunodeficiency 1
propionic acidemia 1
OPS 1
mantle cell lymphoma 1
childhood ALL 1
maple syrup urine disease 1
Proteus syndrome 1
GBS 1
chronic lymphocytic leukemia 1
nephrosis 1
Rett syndrome 1
Prostate Cancer 1
NPC 1
oxalosis 1
pediatric disorder 1
angioid streaks 1
aortic stenosis 1
carcinoma in situ 1
coronary artery disease 1
coronary heart disease 1
adenocarcinoma of the stomach 1
skin cancer 1
psychomotor impairment 1
scoliosis 1
PAM 1
craniosynostosis 1
renal cell carcinoma 1
congenital rubella 1
chronic pain 1
Niemann-Pick 1
hydrocephalus 1
bacterial infection 1
carcinogenesis 1
CRD1 1
nystagmus 1
hypercholesterolemia 1
cystinosis 1
esotropia 1
Barth syndrome 1
achondroplasia 1
leukodystrophy 1
lactic acidosis 1
Dandy-Walker malformation 1
Spleen 1
porphyria 1
glycogen storage disease 1
metachromatic leukodystrophy 1
chronic liver disease 1
lipoprotein disorder 1
battered child syndrome 1
Trichorrhexis nodosa 1
Gastric Cancer 1
Leukemia 1
autoimmune lymphoproliferative syndrome 1
lichen planus 1
intracranial aneurysm 1
xanthoma 1
PARK5 1
vitamin B12 deficiency 1
respiratory disease 1
stuttering 1
cerebral infarction 1
Worms 1
mild mental retardation 1
lung cancer 1
lipomatosis 1
Tay-Sachs disease 1
cerebral palsy 1
dyskeratosis congenita 1
TEM 1
MDS 1
Bazex syndrome 1
ARP1 1
Leber's hereditary optic neuropathy 1
Angiodysplasia 1
inflammatory breast cancer 1
prolapse 1
Hallervorden-Spatz disease 1
glioblastoma multiforme 1
moyamoya 1
HCG 1
brain edema 1
sickle cell disease 1
Alpers 1
Congenital heart disease 1
proteinuria 1
CHS 1
Wiskott-Aldrich syndrome 1
Ovary 1
Sanfilippo syndrome 1
Harada 1
Scheie 1
PLS 1
encephalitis 1
immunopathology 1
tuberculosis 1
developmental disabilities 1
melanosis 1
staghorn calculus 1
CEM 1
ureter 1
arachnodactyly 1
EDS VI 1
Cytotoxic edema 1
multiple sclerosis 1
Pollitt syndrome 1
Kennedy syndrome 1
TEC 1
sensorineural hearing loss 1
IBM 1
generalized seizure 1
peripheral neuropathy 1
Spinal muscular atrophy 1
heart failure 1
lymphedema 1
primary biliary cirrhosis 1
encephalomyelitis 1
Ehlers-Danlos syndrome type VII 1
muscular dystrophy 1
Gastric polyps 1
cholestasis 1
more...
Symptom
seizures 54
hypotonia 25
ataxia 14
dystonia 12
dysarthria 8
hypothermia 8
tremor 6
anesthesia 4
pain 4
emaciation 4
myoclonus 3
cerebellar ataxia 3
ophthalmoplegia 2
spasticity 2
diarrhea 2
weakness 2
lethargy 2
Blotchy 1
Kayser-Fleischer ring 1
tonic seizure 1
clumsiness 1
cough 1
starvation 1
dyspnea 1
hepatomegaly 1
athetosis 1
paraparesis 1
paresis 1
splenomegaly 1
headache 1
Neuropathic pain 1
vomiting 1
blepharospasm 1
partial seizure 1
Drug
Dermatol 19
lysine 5
MAP 3
NADH 3
ascorbate 3
Asn 3
CPT-11 2
Nephron 2
IL-2 2
CSF 2
ADR 1
Leucovorin 1
Nephron 1
Leaf 1
Orphan 1
Cardiovasc 1
Retinoic acid 1
Albumin 1
pyridoxal phosphate 1
HCH 1
ABC 1
vitamin E 1
Satraplatin 1
Dakar 1
Arsenic trioxide 1
Zinc acetate 1
Enzyme
ATPase 212
ceruloplasmin 98
mitogen-activated protein kinase 34
superoxide dismutase 25
lysyl oxidase 22
cytochrome oxidase 21
tyrosinase 11
ERK 11
CCS 7
dopamine beta-hydroxylase 5
PAM 5
monoamine oxidase 4
complex I 4
protein kinase 4
RNA polymerase 4
luciferase 4
catalase 4
MAP 3
diaphorase 3
MEK 3
N-acetylmannosamine kinase 3
caspase-3 3
transcriptase 3
heme oxygenase 3
CNPase 2
aspartate aminotransferase 2
CPR 2
UDP-N-acetylglucosamine 2-epimerase 2
focal adhesion kinase 2
succinate dehydrogenase 2
diamine oxidase 2
ACS 2
proteasome 2
phosphoglycerate kinase 2
prolyl hydroxylase 2
AtHMA4 2
tyrosine hydroxylase 2
PGM 2
type III procollagen 2
phospholipase A2 1
hexokinase 1
MMP 1
NADH dehydrogenase 1
topoisomerase 1
gamma-glutamylcysteine synthetase 1
ascorbate oxidase 1
ribonuclease 1
N-acetylglucosamine 2-epimerase 1
PAH 1
N-acetylglucosamine kinase 1
RNase 1
glutathione reductase 1
Thy1 1
pyruvate dehydrogenase 1
sulfite oxidase 1
hormone-sensitive lipase 1
sialyltransferase 1
lactate dehydrogenase 1
GSK 1
sialyltransferase 1
CCS1 1
sulfhydryl oxidase 1
reverse transcriptase 1
phenol oxidase 1
AMP-activated protein kinase 1
glutathione S-transferase 1
Mg2+-ATPase 1
alcohol dehydrogenase 1
collagenase 1
topoisomerase 1
lysyl hydroxylase 1
chloramphenicol acetyltransferase 1
transaldolase 1
phenylalanine hydroxylase 1
lysozyme 1
glutathione peroxidase 1
sialyltransferase 1
ribonuclease 1
MEKK1 1
calcium pump 1
dihydropyrimidine dehydrogenase 1
chalcone synthase 1
ECH 1
uricase 1
argininosuccinate synthetase 1
sulfite oxidase 1
RNase 1
creatine kinase 1
plasmin 1
prostate-specific antigen 1
phosphodiesterase 1
mannosidase II 1
pyruvate kinase 1
lipoprotein lipase 1
acid phosphatase 1
endoglycosidase H 1
biotinidase 1
alanine aminotransferase 1
ALDH 1
Compound
copper 778
Dec 68
DNA 65
zinc 64
His 61
Clin 60
iron 55
ATP 45
cadmium 25
cysteine 21
oxygen 19
serine 18
silver 14
water 14
calcium 13
leucine 12
acetate 11
Cu(II) 10
methionine 9
threonine 9
sodium 9
arginine 7
alanine 7
lysine 7
CCS 7
sulfate 7
manganese 7
cobalt 6
nickel 6
mercury 6
selenium 6
Arsenate 5
UDP-GlcNAc 5
Cytochrome c 5
N-acetylmannosamine 5
valine 5
Lead 5
tyrosine 4
Serine 4
glucose 4
MTT 4
Gly 4
phosphate 4
Neuronal 4
uridine 4
hydrogen 4
noradrenaline 4
GSH 3
formaldehyde 3
GlcNAc 3
NMDA 3
proline 3
GSH 3
MDA 3
DEAE 3
H2O2 3
nitric oxide 3
tryptophan 3
tryptophan 3
urea 3
NADH 3
Ile 3
tryptophan 3
formaldehyde 3
pyrimidine 3
salt 3
ammonium 3
Guo 3
iodine 3
Parenteral 3
glutamate 3
tryptophan 3
NH2 3
EDTA 3
pyrimidine 3
MAP 3
Phe 2
DDP 2
isoleucine 2
Insulin 2
ACS 2
THP 2
Asp 2
galactose 2
DTT 2
A 3 2
ethanol 2
SDS 2
SN-38 2
Pac 2
ADP 2
Guo 2
ADP 2
ADP 2
cyanide 2
Mg2+ 2
ACS 2
PAM 2
CPT-11 2
nitrogen 2
CPT 2
PAM 2
DTT 2
aniline 2
aluminum 2
isoleucine 2
Elastin 2
THP 2
MEK 2
PAC 2
acrylamide 2
COS 1
aspartic acid 1
carbamic acid 1
Tetracycline 1
Zinc acetate 1
ASC 1
ANA 1
nicotinamide 1
HNO3 1
nicotinic acid 1
Clonazepam 1
AAA 1
CAT 1
HNO3 1
N-acetylaspartate 1
6-aminonicotinamide 1
HNO3 1
HNO3 1
aspartic acid 1
oxalate 1
silicon 1
cyclohexanone 1
thiourea 1
nicotinic acid 1
Evans Blue 1
VMA 1
Brefeldin A 1
Retinal 1
benzamide 1
DDM 1
TNM 1
retinoic acid 1
Sialic acid 1
HNO3 1
Ascorbic acid 1
folinic acid 1
cyclohexanone 1
GABA 1
CCP 1
DOPAC 1
AMPA 1
DMM 1
Melanin 1
HNO3 1
barium 1
cyclohexanone 1
HNO3 1
cyclohexanone 1
HNO3 1
HNO3 1
quinoline 1
DHPG 1
PAH 1
DBH 1
HNO3 1
HNO3 1
CuO 1
Bathocuproine 1
HNO3 1
DDM 1
Tempol 1
ACI 1
HNO3 1
HNO3 1
thiophene 1
CAT 1
TNF 1
hexose 1
Tamoxifen 1
cyclohexanone 1
HNO3 1
3-hydroxyphenylalanine 1
DPPH 1
PCI 1
Heparan sulfate 1
Chloroquine 1
HNO3 1
phosphorus 1
A 1 1
CoA 1
CO2 1
dUTP 1
GTP 1
C-3 1
alcohol dehydrogenase 1
aldehyde 1
HNO3 1
phenol 1
Ethylene 1
HNO3 1
Ang II 1
CMP 1
NO3 1
Ranitidine 1
palmitic acid 1
Rapamycin 1
nicotinic acid 1
HNO3 1
naphthalene 1
Histidine 1
cyclohexanone 1
quinoline 1
NAD 1
HVA 1
piperazine 1
Amide 1
3-hydroxyphenylalanine 1
5-FU 1
aspartic acid 1
Sucrose 1
ADR 1
TCA 1
cyclohexanone 1
HNO3 1
CoQ 1
HNO3 1
NAD 1
ANA 1
Methotrexate 1
UDP 1
Ruthenium red 1
chromate 1
CMP 1
aspartic acid 1
HNO3 1
HNO3 1
Brefeldin A 1
molybdenum 1
salicylic acid 1
Usnic acid 1
nitrate 1
N2O 1
Hematoxylin 1
Tamoxifen 1
Austin 1
Cycloheximide 1
Nitrate 1
Neocuproine 1
CAT 1
hexadecyl 1
Dopa 1
nicotinic acid 1
cyclohexanone 1
HNO3 1
Biuret 1
Pamidronate 1
PDB 1
Isoproterenol 1
3-hydroxyphenylalanine 1
2-mercaptoethanol 1
L-DOPA 1
COI 1
3-hydroxyphenylalanine 1
Norepinephrine 1
Glu-Glu 1
PMP 1
Maps 1
Dopamine 1
Neu5Ac 1
HNO3 1
glutamine 1
Benzo[a]pyrene 1
PAM 1
IDPN 1
His-Leu 1
creatinine 1
aldehyde 1
cyclohexanone 1
Collagen 1
PMP 1
Chloroquine 1
HNO3 1
EDTA 1
HNO3 1
TEC 1
fluorine 1
phosphocreatine 1
1,4,7,10-tetraazacyclododecane 1
GABA 1
TTS 1
glycerol 1
AMP 1
PMP 1
HNO3 1