Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0022716 (Menkes)
 1,057 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ATP7A 260
ATPase 209
MNK 155
Wilson disease 140
X-linked 106
ceruloplasmin 92
ATP7B 86
Mol 86
X-linked recessive 86
Sep 68
MC1 62
metallothionein 53
ATP 45
eIF4E 30
MNK1 25
cytochrome c oxidase 24
lysyl oxidase 24
collagen 23
superoxide dismutase 23
MAPK 21
ATP7A protein 21
ATOX1 18
axonal 17
WND 17
prion 17
MRI 15
MNK2 13
p38 13
GNE 13
endoplasmic reticulum 12
X-chromosome 12
NMR 12
elastin 12
tyrosinase 11
mTOR 11
polypeptide 11
gut 10
amyloid precursor protein 10
ERK 9
eukaryotic translation initiation factor 4E 8
PGK1 8
Met 7
membrane protein 7
ferroxidase 7
membrane-bound 7
CCS 7
fur 6
dopamine beta-hydroxylase 6
AKT 6
adaptor protein 6
SOD1 6
Ceruloplasmin 6
albumin 6
hemochromatosis 6
Metallothionein 6
divalent metal transporter 1 5
AED 5
Cytochrome c 5
SGC 5
fused 5
COMMD1 5
transferrin receptor 5
MIM 5
cytochrome c 5
UTR 5
insulin 5
IP1 4
c-myc 4
Hermansky-Pudlak syndrome 4
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 4
copper transport protein 4
MAP kinase 4
AGS 4
peptidylglycine alpha-amidating monooxygenase 4
catenin 4
p53 4
Bcl-2 4
cyclin D1 4
lymphoid 4
ubiquitin 4
PI3K 4
GTPase 4
ERK1 4
caspase-3 4
cytochrome 4
UDP-GlcNAc 4
SOD 4
beta-actin 4
olfactory 4
copper transporter 1 4
eukaryotic translation initiation factor 4
Mnk1 3
CTR1 3
AP-1 3
4E-BP1 3
MT-2 3
VCP 3
HGC 3
MAP 3
p97 3
MDM 3
dynamin 3
pseudogene 3
mitogen-activated protein 3
precursor protein 3
IBM2 3
NMDA receptor 3
AP19 3
hephaestin 3
Cu/Zn superoxide dismutase 3
oxidoreductase 3
pseudoxanthoma elasticum 3
SOD3 3
phosphatase 3
UDP-N-acetylglucosamine 2-epimerase 3
adenosine triphosphatase 3
transferrin 3
E-cadherin 3
prion protein 3
reductase 3
NADH 3
catalase 3
threonine 3
GSH 3
4EBP1 3
glucose transporter 2
Glutaredoxin-1 2
MK2 2
SCO2 2
interacting protein 2
RAF 2
neurofibromatosis 2
CPX 2
MEK 2
MELAS 2
translation initiation factor 2
N-cadherin 2
proteasome 2
IL-6 2
IRE 2
ferritin 2
APP 2
crinkled 2
MURR1 2
RhoA 2
VEGF 2
Ku80 2
ICP 2
CD8 2
pyrroline-5-carboxylate synthetase 2
MRS 2
ACS 2
Myc protein 2
N-acetylmannosamine kinase 2
pituitary adenylate cyclase-activating polypeptide 2
neurofibromatosis type 1 2
cytokine 2
calcium pump 2
COG7 2
CSF 2
more...
Disease
Menkes 1057
Wilson's disease 80
Alzheimer's disease 47
cancer 42
tumor 24
disorders of copper metabolism 23
neuropathy 21
mental retardation 17
mental retardation 17
amyotrophic lateral sclerosis 16
brain atrophy 16
epilepsy 15
cutis laxa 15
Ehlers-Danlos syndrome 15
iron deficiency 14
genetic disorder 14
anemia 14
failure to thrive 13
Parkinson's disease 13
myopathy 12
Copper deficiency 12
developmental delay 11
malnutrition 10
encephalopathy 9
acrodermatitis enteropathica 9
malabsorption 8
neurological disease 8
cirrhosis 8
tumorigenesis 8
breast cancer 8
metabolic disorder 7
gastric cancer 7
carcinoma 7
hemochromatosis 7
prostate cancer 7
muscular atrophy 7
adenocarcinoma 6
osteogenesis imperfecta 6
fits 6
glioma 6
Huntington's disease 6
trichorrhexis 6
tumor growth 6
dysplasia 6
Evans 6
cerebral degeneration 6
Syndrome 6
acute myeloid leukemia 5
Marfan syndrome 5
gastroesophageal reflux disease 5
Leigh syndrome 5
hepatocellular carcinoma 5
connective tissue disease 5
diabetes 5
OHS 5
hypertension 4
incontinentia pigmenti 4
profound mental retardation 4
ICC 4
glioblastoma 4
hemiplegic migraine 4
tumor progression 4
neuroblastoma 4
SMAX3 4
Hermansky-Pudlak syndrome 4
dementia 4
heart disease 4
AGS 4
leukemia 4
West 4
osteoporosis 4
ichthyosis 4
severe mental retardation 4
Pili torti 4
macrocephaly 4
schizophrenia 3
deafness 3
abortion 3
urinary tract infection 3
Ehlers-Danlos syndrome type IX 3
optic atrophy 3
glutaric aciduria 3
scurvy 3
mitochondrial disease 3
homocystinuria 3
neurofibromatosis type 1 3
neuronal ceroid lipofuscinosis 3
parkinsonism 3
congenital disorder 3
Legionella 3
hygroma 3
chondrodysplasia 3
melanoma 3
cornea 3
liver disease 3
chronic hepatitis 3
ischemia 3
GSH 3
QSM 3
Placenta 3
enteropathy 3
epidermolysis bullosa 3
pseudoxanthoma elasticum 3
tuberous sclerosis 3
Kearns-Sayre syndrome 3
rare disease 3
child abuse 3
ichthyosis 3
MCF 3
multiple myeloma 3
phenylketonuria 3
Netherton syndrome 3
mitochondrial encephalomyopathy 3
Friedreich's ataxia 3
atherosclerosis 3
ALD 2
hereditary hemochromatosis 2
acute lymphoblastic leukemia 2
glucose intolerance 2
hydronephrosis 2
plaque 2
obesity 2
Crohn's disease 2
Gaucher disease 2
MELAS 2
chronic myeloid leukemia 2
cognitive impairment 2
stroke 2
neuromuscular disorder 2
GCE 2
squamous cell carcinoma 2
status epilepticus 2
angiodysplasia 2
varices 2
choreoathetosis 2
Fabry 2
MRS 2
neutropenia 2
mole 2
respiratory infection 2
myocardial ischemia 2
nevoid basal cell carcinoma syndrome 2
SWS 2
ICP 2
mole 2
retinitis pigmentosa 2
infectious diseases 2
cold 2
ectodermal dysplasia 2
cardiovascular disease 2
metastases 2
motor neuron disease 2
depression 2
inguinal hernia 2
PBT 2
cardiomyopathy 2
respiratory failure 2
hemosiderosis 2
CPX 2
Dermal 2
more...
Symptom
seizures 54
hypotonia 25
ataxia 14
dystonia 12
dysarthria 8
hypothermia 8
tremor 6
anesthesia 4
pain 4
emaciation 4
myoclonus 3
cerebellar ataxia 3
ophthalmoplegia 2
spasticity 2
diarrhea 2
weakness 2
lethargy 2
Blotchy 1
Kayser-Fleischer ring 1
tonic seizure 1
clumsiness 1
cough 1
starvation 1
dyspnea 1
hepatomegaly 1
athetosis 1
paraparesis 1
paresis 1
splenomegaly 1
headache 1
Neuropathic pain 1
vomiting 1
blepharospasm 1
partial seizure 1
Drug
Dermatol 19
lysine 5
MAP 3
NADH 3
ascorbate 3
Asn 3
CPT-11 2
Nephron 2
IL-2 2
CSF 2
ADR 1
Leucovorin 1
Nephron 1
Leaf 1
Orphan 1
Cardiovasc 1
Retinoic acid 1
Albumin 1
pyridoxal phosphate 1
HCH 1
ABC 1
vitamin E 1
Satraplatin 1
Dakar 1
Arsenic trioxide 1
Zinc acetate 1
Enzyme
ATPase 212
ceruloplasmin 98
mitogen-activated protein kinase 34
superoxide dismutase 25
lysyl oxidase 22
cytochrome oxidase 21
tyrosinase 11
ERK 11
CCS 7
dopamine beta-hydroxylase 5
PAM 5
monoamine oxidase 4
complex I 4
protein kinase 4
RNA polymerase 4
luciferase 4
catalase 4
MAP 3
diaphorase 3
MEK 3
N-acetylmannosamine kinase 3
caspase-3 3
transcriptase 3
heme oxygenase 3
CNPase 2
aspartate aminotransferase 2
CPR 2
UDP-N-acetylglucosamine 2-epimerase 2
focal adhesion kinase 2
succinate dehydrogenase 2
diamine oxidase 2
ACS 2
proteasome 2
phosphoglycerate kinase 2
prolyl hydroxylase 2
AtHMA4 2
tyrosine hydroxylase 2
PGM 2
type III procollagen 2
phospholipase A2 1
hexokinase 1
MMP 1
NADH dehydrogenase 1
topoisomerase 1
gamma-glutamylcysteine synthetase 1
ascorbate oxidase 1
ribonuclease 1
N-acetylglucosamine 2-epimerase 1
PAH 1
N-acetylglucosamine kinase 1
RNase 1
glutathione reductase 1
Thy1 1
pyruvate dehydrogenase 1
sulfite oxidase 1
hormone-sensitive lipase 1
sialyltransferase 1
lactate dehydrogenase 1
GSK 1
sialyltransferase 1
CCS1 1
sulfhydryl oxidase 1
reverse transcriptase 1
phenol oxidase 1
AMP-activated protein kinase 1
glutathione S-transferase 1
Mg2+-ATPase 1
alcohol dehydrogenase 1
collagenase 1
topoisomerase 1
lysyl hydroxylase 1
chloramphenicol acetyltransferase 1
transaldolase 1
phenylalanine hydroxylase 1
lysozyme 1
glutathione peroxidase 1
sialyltransferase 1
ribonuclease 1
MEKK1 1
calcium pump 1
dihydropyrimidine dehydrogenase 1
chalcone synthase 1
ECH 1
uricase 1
argininosuccinate synthetase 1
sulfite oxidase 1
RNase 1
creatine kinase 1
plasmin 1
prostate-specific antigen 1
phosphodiesterase 1
mannosidase II 1
pyruvate kinase 1
lipoprotein lipase 1
acid phosphatase 1
endoglycosidase H 1
biotinidase 1
alanine aminotransferase 1
ALDH 1
Compound
copper 778
Dec 68
DNA 65
zinc 64
His 61
Clin 60
iron 55
ATP 45
cadmium 25
cysteine 21
oxygen 19
serine 18
silver 14
water 14
calcium 13
leucine 12
acetate 11
Cu(II) 10
methionine 9
sodium 9
threonine 9
arginine 7
CCS 7
alanine 7
sulfate 7
lysine 7
manganese 7
cobalt 6
nickel 6
selenium 6
mercury 6
Arsenate 5
Cytochrome c 5
Lead 5
UDP-GlcNAc 5
valine 5
N-acetylmannosamine 5
hydrogen 4
Neuronal 4
Serine 4
MTT 4
Gly 4
glucose 4
phosphate 4
tyrosine 4
uridine 4
noradrenaline 4
pyrimidine 3
DEAE 3
tryptophan 3
tryptophan 3
pyrimidine 3
proline 3
Guo 3
GSH 3
NH2 3
GlcNAc 3
H2O2 3
ammonium 3
MAP 3
Parenteral 3
iodine 3
MDA 3
tryptophan 3
NADH 3
tryptophan 3
Ile 3
formaldehyde 3
NMDA 3
formaldehyde 3
glutamate 3
GSH 3
EDTA 3
salt 3
nitric oxide 3
urea 3
Phe 2
Asp 2
isoleucine 2
isoleucine 2
aniline 2
THP 2
MEK 2
PAC 2
DTT 2
ethanol 2
galactose 2
Pac 2
A 3 2
ADP 2
aluminum 2
Guo 2
ADP 2
THP 2
DDP 2
ADP 2
Mg2+ 2
Insulin 2
PAM 2
PAM 2
CPT-11 2
ACS 2
CPT 2
nitrogen 2
cyanide 2
DTT 2
Elastin 2
SN-38 2
ACS 2
SDS 2
acrylamide 2
AAA 1
HNO3 1
Tetracycline 1
HNO3 1
Zinc acetate 1
COI 1
nicotinamide 1
silicon 1
HNO3 1
CAT 1
hexadecyl 1
nicotinic acid 1
Evans Blue 1
thiourea 1
VMA 1
Pamidronate 1
benzamide 1
Norepinephrine 1
aspartic acid 1
HNO3 1
glutamine 1
retinoic acid 1
TEC 1
cyclohexanone 1
GABA 1
CCP 1
DOPAC 1
DMM 1
barium 1
cyclohexanone 1
Ascorbic acid 1
folinic acid 1
HNO3 1
cyclohexanone 1
HNO3 1
HNO3 1
quinoline 1
DHPG 1
AMPA 1
Melanin 1
HNO3 1
PAH 1
HNO3 1
HNO3 1
Bathocuproine 1
Tempol 1
ACI 1
TNF 1
HNO3 1
more...