Gene/Protein
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Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
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Target Concepts:
Gene/Protein
Disease
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Drug
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Query: UMLS:C0022716 (
Menkes
)
1,057
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are involved in oncogenic transformation and can promote metastasis and tumor progression. In human cells, there are four MNKs isoforms (MNK1a/b and MNK2a/b), derived from two genes by alternative splicing. These kinases play an important role controlling the expression of specific proteins involved in cell cycle, cell survival and cell motility via eukaryotic initiation factor 4E (eIF4E) regulation, but also through other substrates such as heterogeneous nuclear ribonucleoprotein A1,
polypyrimidine tract-binding protein-associated splicing factor
and Sprouty 2. In this review, we provide an overview of the role of
MNK
in human cancers, describing the studies conducted to date to elucidate the mechanism involved in the action of MNKs, as well as the development of
MNK
inhibitors in different hematological cancers and solid tumors.
...
PMID:Deeping in the Role of the MAP-Kinases Interacting Kinases (MNKs) in Cancer. 3234 Jan 35
